Results 111 to 120 of about 2,295,017 (227)
Transcription and the Pitch Angle of DNA [PDF]
, 2013 The question of the value of the pitch angle of DNA is visited from the perspective of a geometrical analysis of transcription. It is suggested that for transcription to be possible, the pitch angle of B-DNA must be smaller than the angle of zero-twist ...
Bohr J +3 more
core +2 more sources
ChemistryOpen, Volume 15, Issue 5, May 2026.Ferrocene derivatives represent a transformative class of molecular sensors, combining exceptional electrochemical stability with tunable redox characteristics that enable precise detection across diverse analytical challenges in environmental, medical, and industrial applications.
Ala'a Al‐Akhras +6 more
wiley +1 more source
Nucleic Acids Research, 2014 The Escherichia coli H-NS protein is a major nucleoid-associated protein that is involved in chromosomal DNA packaging and gene regulatory functions.
C. Lim, L. Kenney, Jie Yan
semanticscholar +1 more source
Twist/Writhe Partitioning in a Coarse-Grained DNA Minicircle Model
, 2009 Here we present a systematic study of supercoil formation in DNA minicircles under varying linking number by using molecular dynamics simulations of a two-bead coarse-grained model. Our model is designed with the purpose of simulating long chains without
Alkan Kabakçıoğlu +3 more
core +1 more source
Reverse gyrase—recent advances and current mechanistic understanding of positive DNA supercoiling
Nucleic Acids Research, 2014 Reverse gyrases are topoisomerases that introduce positive supercoils into DNA in an ATP-dependent reaction. They consist of a helicase domain and a topoisomerase domain that closely cooperate in catalysis.
Pavel Lulchev, D. Klostermeier
semanticscholar +1 more source
Trapping of the transport-segment DNA by the ATPase domains of a type II topoisomerase
Nature Communications, 2018 Type 2 topoisomerases alter DNA supercoiling by an ATP-dependent reaction involving DNA passage through a cleaved DNA duplex. Here the authors present the crystal structure of the ParE ATPase domains of S.
Ivan Laponogov +6 more
doaj +1 more source
Our Evolving Understanding of the Mechanism of Quinolones
Antibiotics, 2018 The maintenance of DNA supercoiling is essential for the proper regulation of a plethora of biological processes. As a consequence of this mode of regulation, ahead of the replication fork, DNA replication machinery is prone to introducing supercoiled ...
Arnaud Gutierrez +2 more
doaj +1 more source
From RNA to DNA: How Cargo Identity Reprograms Lipid Nanoparticle Architecture and Function
Advanced Healthcare Materials, Volume 15, Issue 16, 24 April 2026.The evolution of lipid nanoparticles (LNPs) spans from RNA‐LNPs, used in mRNA vaccines, to DNA‐LNPs, ideal for gene therapies. Emerging bionano architectures, decorated with DNA and plasma proteins, pave the way for advanced DNA‐based therapies that are more stable, targeted, and customizable.
Erica Quagliarini +2 more
wiley +1 more source
Bioengineering, 2019 There is an increased interest in plasmid DNA as therapeutics. This is evident in the number of ongoing clinical trials involving the use of plasmid DNA.
Olusegun Folarin +3 more
doaj +1 more source
Specific anchoring of large topologically closed DNA for single-molecule protein:DNA interactions
Biophysical ReportsSingle-molecule and bulk biophysical approaches to study protein-DNA interactions on surface-immobilized nucleic acid templates typically rely on modifying the ends of linear DNA molecules to enable surface-DNA attachments.
Neville S. Gilhooly +1 more
doaj +1 more source