Results 101 to 110 of about 2,295,017 (227)
Biological Consequences of Tightly Bent DNA: The Other Life of a Macromolecular Celebrity [PDF]
, 2006 The mechanical properties of DNA play a critical role in many biological functions. For example, DNA packing in viruses involves confining the viral genome in a volume (the viral capsid) with dimensions that are comparable to the DNA persistence length ...
Garcia, Hernan G. +8 more
core +3 more sources
MicrobiologyOpen, Volume 15, Issue 3, June 2026.IMP‐1700 enhances the cytotoxic effect on bacteria in combination with either ciprofloxacin (CPX) or X‐ray. In noncancerous and tumor cells, combination treatments markedly reduce viability with radiosensitizing effects. Further studies are needed to clarify the mechanism underlying IMP‐1700s effects on mammalian cells. Created in BioRender. Kjaer, A. (
Ida Vang Andersen +7 more
wiley +1 more source
Influence of supercoiling on the disruption of dsDNA
, 2004 We propose that supercoiling energizes double-stranded DNA (dsDNA) so as to facilitate thermal fluctuations to an unzipped state. We support this with a model of two elastic rods coupled via forces that represent base pair interactions.
Binney J. J. +5 more
core +1 more source
Chromosome segregation in a minimal bacterial cell driven by SMC protein complexes
Protein Science, Volume 35, Issue 6, June 2026.Abstract Minimal bacterial cells such as JCVI‐Syn3A provide a powerful system for uncovering the essential mechanisms of chromosome organization and segregation. Lacking canonical systems such as Min and ParABS, JCVI‐Syn3A relies primarily on structural maintenance of chromosomes (SMC) protein complexes for partitioning.
Andrew K. Maytin +2 more
wiley +1 more source
Evidence for a Solenoid Phase of Supercoiled DNA
, 2018 In mechanical manipulation experiments, a single DNA molecule overwound at constant force undergoes a discontinuous drop in extension as it buckles and forms a superhelical loop (a plectoneme).
Dittmore, Andrew, Neuman, Keir C.
core +1 more source
DNA supercoiling in gyrase mutants [PDF]
Journal of Bacteriology, 1984 Nucleoids isolated from Escherichia coli strains carrying temperature-sensitive gyrA or gyrB mutations were examined by sedimentation in ethidium bromide-containing sucrose density gradients. A shift to restrictive temperature resulted in nucleoid DNA relaxation in all of the mutant strains.
T R, Steck +4 more
openaire +2 more sources
ChemPhysChem, Volume 27, Issue 9, 14 May 2026.The nucleoid‐associated proteins Dps, H‐NS, and HU shape the bacterial chromosome in the deep stationary phase through their interactions with the nucleoid.The bacterial nucleoid undergoes extensive structural reorganization during growth, influenced by nucleoid‐associated proteins (NAPs) whose interactions and effects on nucleoid organization remain ...
D. E. H. Fuller +5 more
wiley +1 more source
DNA supercoiling regulates the stress-inducible expression of genes in the cyanobacterium Synechocystis [PDF]
, 2009 Changes in the supercoiling of genomic DNA play an important role in the regulation of gene expression. We compared the genome-wide expression of genes in cells of the cyanobacterium Synechocystis sp.
Kupriyanova Elena +7 more
core +1 more source
Current Protocols, Volume 6, Issue 5, May 2026.Abstract Alveolar epithelial cell type 1 (AT1) and type 2 (AT2) cells make up the saccular gas exchange units of the lung, called alveoli. Formation of alveoli during lung development accounts for the expansive surface area of the lung, allowing for proper respiration and delivery of oxygen to the body.
Evelyn Tran +11 more
wiley +1 more source
Elasticity model of a supercoiled DNA molecule
, 1997 Within a simple elastic theory, we study the elongation versus force characteristics of a supercoiled DNA molecule at thermal equilibrium in the regime of small supercoiling.
A. Comtet +15 more
core +1 more source