Results 101 to 110 of about 1,452,122 (130)

Inhibition of topoisomerase 2 catalytic activity impacts the integrity of heterochromatin and repetitive DNA and leads to interlinks between clustered repeats

Nature Communications
DNA replication and transcription generate DNA supercoiling, which can cause topological stress and intertwining of daughter chromatin fibers, posing challenges to the completion of DNA replication and chromosome segregation.
Michalis Amoiridis, John Verigos, Karen Meaburn, William H. Gittens, Tao Ye, Matthew J. Neale, Evi Soutoglou   +6 more
doaj   +1 more source

Inhibitory effect of DNA supercoiling on DNA knotting

, 2009
Using numerical simulations we investigated the effect of DNA supercoiling on the topological equilibrium of DNA molecules. We showed that under the steady state conditions that maintain the same effective deficit of the linking number in unknotted and ...
Dorier, J., Burnier, Y., Stasiak, A.
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Supercoiling Induces Denaturation Bubbles in Circular DNA

We present a theoretical framework for the thermodynamic properties of supercoiling-induced denaturation bubbles in circular double-stranded DNA molecules.
Metzler, Ralf, Adamcik, Jozef, Jeon, Jae-Hyung, Dietler, Giovanni   +3 more
core   +1 more source

DNA supercoiling by gyrase is linked to nucleoid compaction

, 2002
The genes of E. coli are located on a circular chromosome of 4.6 million basepairs. This 1.6 mm long molecule is compressed into a nucleoid to fit inside the 1-2 μm cell in a functional format.
Stuger, R., Snoep, J.L., Westerhoff, H.V., Snoep, J.L.; id_orcid, Woldringh, C.L., Vischer, N.O.E., Bakker, B.M., van der Weijden, C.C., Westerhoff, H.V.; id_orcid, Stuger, J.R., van Spanning, R.J.M.   +10 more
core   +1 more source

Antimicrobial Activity of 2-(Piperazin-1-yl)naphtho[2,3-d]thiazole-4,9-dione against Staphylococcus Strains

Molecules
There is an urgent need to discover and develop novel antibacterial agents. Accordingly, we synthesised 2-(piperazin-1-yl)naphtho[2,3-d]thiazole-4,9-dione (PNT), which exhibits antimicrobial activity.
Tamami Haraguchi, Saki Hayashi, Seira Nakasaka, Yoshiro Hatanaka, Toshihiro Nagao, Shigemitsu Tanaka, Miki Yoshii, Fumiko Hara, Masayori Hagimori, Miyako Yoshida   +9 more
doaj   +1 more source

Interplay of DNA supercoiling and catenation during the segregation of sister duplexes [PDF]

, 2017
The discrete regulation of supercoiling, catenation and knotting by DNA topoisomerases is well documented both in vivo and in vitro, but the interplay between them is still poorly understood. Here we studied DNA catenanes of bacterial plasmids arising as
Witz, Guillaume, Schvartzman, Jorge B., Stasiak, Andrzej, Hernández, Pablo, Martínez-Robles, María Luisa, Krimer, Dora B.   +5 more
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DNA supercoiling inhibits DNA knotting

, 2008
Despite the fact that in living cells DNA molecules are long and highly crowded, they are rarely knotted. DNA knotting interferes with the normal functioning of the DNA and, therefore, molecular mechanisms evolved that maintain the knotting and ...
Yannis Burnier, Julien Dorier, Andrzej Stasiak   +2 more
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The benefit of DNA supercoiling during replication

, 2020
DNA topology changes dynamically during DNA replication. Supercoiling, precatenation, catenation and knotting interplay throughout the process that is finely regulated by DNA topoisomerases.
Jorge B Schvartzman, Pablo Hernández, Dora B Krimer, María-Luisa Martínez-Robles   +3 more
core  

TOP2B modulates DNA supercoiling and chromatin contacts during transcriptional induction

Human type-II topoisomerases, TOP2A and TOP2B, resolve transcription-associated DNA supercoiling, therebyinfluencing gene expression programs, and have been recently linked to three-dimensional genome architecturethrough yet poorly understood mechanisms.
Millán Zambrano, Gonzalo, Terrón Bautista, José, Cortés Ledesma, Felipe, Díaz Maldonado, Héctor, Bejarano Franco, Marina, Martínez Sánchez, María del Mar, Santiago Gómez, Angélica, López Hernández, Laura, Kidane, Sara, Aguilera López, Andrés   +9 more
core   +1 more source

DNA supercoiling and transcription: a two-way street

, 2019
Background : The processes of DNA supercoiling and transcription are interdependent because the movement of a transcription elongation complex simultaneously induces under- and over winding of the DNA duplex and because the initiation, elongation and ...
Dorman, Charles
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