Results 21 to 30 of about 57,780 (287)
SUMO: A Swiss Army Knife for Eukaryotic Topoisomerases
Frontiers in Molecular Biosciences, 2022 Topoisomerases play crucial roles in DNA metabolism that include replication, transcription, recombination, and chromatin structure by manipulating DNA structures arising in double-stranded DNA.
Yilun Sun, John L. Nitiss, Yves Pommier
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Identification of two novel type II topoisomerase mutations in Enterococcus spp. isolated from a hospital in China [PDF]
Archives of Biological Sciences, 2021 Type II topoisomerases, including DNA gyrase (GyrA) and topoisomerase IV (ParC), contribute to fluoroquinolone resistance in Enterococcus spp. This study investigated the mutational status of the quinolone resistance-determining regions (QRDRs) of GyrA ...
Su Rina +4 more
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Tightening of DNA knots by supercoiling facilitates their unknotting by type II DNA topoisomerases [PDF]
Proceedings of the National Academy of Sciences, 2011 Using numerical simulations, we compare properties of knotted DNA molecules that are either torsionally relaxed or supercoiled. We observe that DNA supercoiling tightens knotted portions of DNA molecules and accentuates the difference in curvature between knotted and unknotted regions. The increased curvature of knotted regions is expected to make them
Guillaume Witz, G. Dietler, A. Stasiak
semanticscholar +4 more sources
Inhibition of Zn(II) binding type IA topoisomerases by organomercury compounds and Hg(II). [PDF]
PLoS ONE, 2015 Type IA topoisomerase activities are essential for resolving DNA topological barriers via an enzyme-mediated transient single strand DNA break. Accumulation of topoisomerase DNA cleavage product can lead to cell death or genomic rearrangement.
Bokun Cheng +4 more
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Transcription facilitated genome-wide recruitment of topoisomerase I and DNA gyrase. [PDF]
PLoS Genetics, 2017 Movement of the transcription machinery along a template alters DNA topology resulting in the accumulation of supercoils in DNA. The positive supercoils generated ahead of transcribing RNA polymerase (RNAP) and the negative supercoils accumulating behind
Wareed Ahmed +5 more
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DNA topoisomerase II is involved in regulation of cyst wall protein genes and differentiation in Giardia lamblia. [PDF]
PLoS Neglected Tropical Diseases, 2013 The protozoan Giardia lamblia differentiates into infectious cysts within the human intestinal tract for disease transmission. Expression of the cyst wall protein (cwp) genes increases with similar kinetics during encystation.
Bo-Chi Lin +7 more
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Cryo-EM structures of African swine fever virus topoisomerase
mBio, 2023 Type II topoisomerases ubiquitously exist in cellular organisms, where they play an essential role in resolving the topological problems of DNA. The viral type II topoisomerase encoded by the African swine fever virus (ASFV) is critical for viral ...
Yan Zhao +5 more
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Antibiotics, 2023 Novel bacterial topoisomerase inhibitors (NBTIs) are a new class of antibacterial agents that target bacterial type II topoisomerases (DNA gyrase and topoisomerase IV). Our recently disclosed crystal structure of an NBTI ligand in complex with DNA gyrase
Maja Kokot +5 more
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Pif1-Family helicases support fork convergence during DNA replication termination in eukaryotes [PDF]
, 2019 The convergence of two DNA replication forks creates unique problems during DNA replication termination. In E. coli and SV40, the release of torsional strain by type II topoisomerases is critical for converging replisomes to complete DNA synthesis, but ...
Baxter, Jonathan +4 more
core +6 more sources
Chromatinization modulates topoisomerase II processivity
Nature Communications, 2023 Type IIA topoisomerases are essential DNA processing enzymes that must robustly and reliably relax DNA torsional stress. While cellular processes constantly create varying torsional stress, how this variation impacts type IIA topoisomerase function ...
Jaeyoon Lee +10 more
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