Results 101 to 110 of about 28,674 (272)
VIEW, EarlyView.Abstract Ninety percent of all primary liver malignancies are hepatocellular carcinomas (HCC), making liver cancer the third most common cause of cancer‐associated mortality. Different patterns of programmed cell death (PCD) are crucial for the survival of tumors, and they might serve as a prognostic marker for HCC.
Lin Ding +10 more
wiley +1 more source
VIEW, EarlyView.We present ChitoSilkBioPatch, a maleimide‐functionalized chitosan/dACM hydrogel integrated with a stretchable nanopatterned silk mesh to provide intrinsic, antibiotic‐free antibacterial activity and bioactive wound support. The scaffold eliminates S. aureus and P.
Dorsa Dehghan‐Baniani +12 more
wiley +1 more source
What's on the Other Side of the Gate: A Structural Perspective on DNA Gate Opening of Type IA and IIA DNA Topoisomerases. [PDF]
Int J Mol Sci, 2023 Vidmar V, Vayssières M, Lamour V.
europepmc +1 more source
VIEW, EarlyView.This study investigates the molecular alterations underlying angiotensin II (Ang II)‐induced vascular remodeling in cardiovascular diseases using a multi‐omics approach. Through data exploration and integrated multi‐omics analysis, our findings reveal that Ang II‐driven vascular injury in vascular smooth muscle cells is mediated by metabolic ...
Yiwei Hu +8 more
wiley +1 more source
Balanced translocations involving chromosome bands 11q23 and 21q22 are highly characteristic of myelodysplasia and leukemia following therapy with cytostatic agents targeting at DNA-topoisomerase II [letter] [PDF]
, 1991 J Pedersen-Bjergaard, P Philip
openalex +1 more source
Asia-Pacific Journal of Clinical Oncology, EarlyView.ABSTRACT Trastuzumab deruxtecan (T‐DXd) is a third‐generation, HER2‐targeting antibody‐drug conjugate that has been shown to significantly prolong overall survival, compared with standard chemotherapy, when used to treat patients who have “HER2‐low” (HER2 immunohistochemistry [IHC] score 1+; or HER2 IHC 2+ plus in situ hybridization‐negative ...
Andrew Redfern +8 more
wiley +1 more source
New Insights into the Geometry and Topology of DNA Replication Intermediates
BiologyThe regulation of superhelical stress, mediated by the combined action of topoisomerases and fork rotation, is crucial for DNA replication. The conformational changes during DNA replication are still experimentally challenging, mainly due to the rapid ...
Victor Martínez +7 more
doaj +1 more source
Imatinib enchances the sensitivity of gastrointestinal stromal tumors to topoisomerase II inhibitors
Успехи молекулярной онкологии, 2015 Objective: to study the sensitivity of gastrointestinal stromal tumors (GISTs) to the topoisomerases type II inhibitors and ability of imatinib to enhance GISTs sensitivity to the chemotherapeutic drugs indicated above.Subjects and Methods.
S. V. Boichuk +3 more
doaj +1 more source
The Rabl configuration limits topological entanglement of chromosomes in budding yeast. [PDF]
, 2019 The three dimensional organization of genomes remains mostly unknown due to their high degree of condensation. Biophysical studies predict that condensation promotes the topological entanglement of chromatin fibers and the inhibition of function.
Arsuaga, Javier +5 more
core
British Journal of Haematology, EarlyView.Summary VEXAS syndrome (vacuoles, E1 enzyme, X‐linked, autoinflammatory, somatic) is an X‐linked, systemic, haemato‐inflammatory syndrome caused by somatic mutations in the UBA1 gene. No standardized treatment guidelines exist, but evidence is emerging that treatment with hypomethylating agents (HMAs) can induce improvement of the inflammatory symptoms,
Fieke W. Hoff +3 more
wiley +1 more source