Results 201 to 210 of about 1,464,924 (278)

Proteostasis of organelles in aging and disease

The FEBS Journal, Volume 293, Issue 18, Page 5600-5626, September 2026.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

[Expression of Concern] Suppression of PTEN/AKT signaling decreases the expression of TUBB3 and TOP2A with subsequent inhibition of cell growth and induction of apoptosis in human breast cancer MCF-7 cells via ATP and caspase-3 signaling pathways. [PDF]

Oncol Rep
Yang Z, Liu Y, Shi C, Zhang Y, Lv R, Zhang R, Wang Q, Wang Y.   +7 more
europepmc   +1 more source

Synthesis and dissolution of hemicatenanes by type IA DNA topoisomerases. [PDF]

Proc Natl Acad Sci U S A, 2013
Lee SH, Siaw GE, Willcox S, Griffith JD, Hsieh TS.   +4 more
europepmc   +1 more source

Cell‐Specific Expression and Cellular Compartmental Regulation in Camptothecin Biosynthesis

Plant Biotechnology Journal, Volume 24, Issue 9, Page 5114-5130, September 2026.
ABSTRACT Plant secondary metabolites such as monoterpenoid indole alkaloids (MIAs) show tightly regulated biosynthesis and accumulation in specific organelles of distinct cell types. However, the cell‐specific expression patterns of anticancer MIA camptothecin biosynthetic genes in Ophiorrhiza pumila and the regulatory mechanisms of camptothecin ...
Xiaolong Hao, Yinkai Yang, Tiantian Chen, Xiaoxuan Fan, Yiqing Peng, Qingyan Ruan, Qin Zhou, Fanghao Liu, Jiayi He, Yongpeng Li, Yue Feng, Jiyan Qi, Guoyin Kai   +12 more
wiley   +1 more source

Mechanistic basis for relaxation of DNA supercoils by human topoisomerase IIIα-RMI1-RMI2. [PDF]

Proc Natl Acad Sci U S A
Spakman D, Biebricher AS, Bizard AH, Hickson ID, Peterman EJG, Wuite GJL, King GA.   +6 more
europepmc   +1 more source

RAD51 and RAD51 paralog inhibition sensitizes nonreplicating quiescent keratinocytes to UV radiation

Photochemistry and Photobiology, Volume 102, Issue 5, Page 1138-1149, September/October 2026.
UV radiation and other compounds generate DNA adducts that block transcription and induce cell death if not removed by the nucleotide excision repair system. In this work, we used a small‐scale pharmacological screen to discover that inhibition of the recombinase RAD51 sensitized nonreplicating quiescent keratinocytes to both UVR and other agents that ...
Saman Khan, Angitha Nair, M. Alexandra Carpenter, Michael G. Kemp   +3 more
wiley   +1 more source

Medicinal and Crop Protection Chemistry: Breaking Barriers, Building Synergies

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
A unified view of medicinal and crop protection chemistry reveals shared scientific progress, common challenges, and new opportunities for cross‐disciplinary collaboration. Bridging expertise across both fields could accelerate innovation and actively encourage more sustainable solutions.
Giulia Cazzaniga, Giusy L. Fratello, Alexander T. Apostle, Roberto Orru, David M. Barber, Silvia Gazzola   +5 more
wiley   +1 more source

Molecular dynamics simulations reveal DNA gate opening mechanisms for M. smegmatis topoisomerase 1A. [PDF]

Biophys J
Sigdel D, Mills M.
europepmc   +1 more source

Reversible Coordination Modes in Piperazine‐Based Ru(II)‐p‐Cymene Acylthiourea Complexes: Modulating DNA Groove Binding for Selective Antimelanoma Activity

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Piperazine‐based monodentate and S,N‐bidentate Ru(II)‐p‐cymene complexes were synthesized through distinct coordination strategies and evaluated for antimelanoma activity. Among the investigated compounds, the S,N‐bidentate complex 2b exhibited significantly enhanced cytotoxicity (IC50 = 6.1 ± 0.8 ) against melanoma cells, particularly the A375 cell ...
Amir Karim, Xin Wang, Yu‐Ting Chu, Rahimeh Eshaghi Malekshah, En‐De Shu, Najeeb Ullah, Chien‐Chih Chiu, Ching‐Ming Chien, Sodio C. N. Hsu   +8 more
wiley   +1 more source

IID432, a parasite-selective topoisomerase II inhibitor, achieves rapid single-dose parasite clearance in a murine chronic Chagas model. [PDF]

Proc Natl Acad Sci U S A
Saldivia M, Jumani RS, Thomas B, Baxley GM, Sancheti J, Bullara D, Galarneau JR, Cheung H, Chen YL, DeAsis RS, Patra D, René O, Noeske J, Schenk AD, Deniston C, Thakore S, Luu C, Wartchow C, Koester DC, Francisco AF, Blais J, Jiricek J, Hollingsworth SA, Gable JE, Kelly JM, Hochberg N, Knutson CG, Lakshminarayana SB, Sarko C, Manjunatha UH, Osborne CS, Diagana TT, Rao SPS.   +32 more
europepmc   +1 more source