Results 221 to 230 of about 1,464,924 (278)
Flavonoids as Dual Topoisomerase I and II Inhibitors: Mechanistic Insights and Emerging Anticancer Strategies. [PDF]
Chem BiodiversParua P +7 more
europepmc +1 more source
Topological Regulation of the Mammalian Genome by Positive DNA Supercoiling
Singh AK +4 more
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Origin and evolution of DNA topoisomerases
Biochimie, 2007 The DNA topoisomerases are essential for DNA replication, transcription, recombination, as well as for chromosome compaction and segregation. They may have appeared early during the formation of the modern DNA world. Several families and subfamilies of the two types of DNA topoisomerases (I and II) have been described in the three cellular domains of ...
Patrick Forterre +2 more
exaly +6 more sources
Journal of Medicinal Chemistry, 2017 DNA topoisomerases constitute a large family of enzymes that are essential for all domains of life. Although they share general reaction chemistry and the capacity to govern DNA topology and resolve strand entanglements during fundamental molecular processes, they are characterized by differences in their structural organization, modes of enzymatic ...
CAPRANICO, GIOVANNI +2 more
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EcoSal Plus, 2009
DNA topoisomerases are enzymes that control the topological state of DNA in all cells; they have central roles in DNA replication and transcription. They are classified into two types, I and II, depending on whether they catalyze reactions involving the breakage of one or both strands of DNA.
Katherine, Evans-Roberts +1 more
openaire +3 more sources
DNA topoisomerases are enzymes that control the topological state of DNA in all cells; they have central roles in DNA replication and transcription. They are classified into two types, I and II, depending on whether they catalyze reactions involving the breakage of one or both strands of DNA.
Katherine, Evans-Roberts +1 more
openaire +3 more sources
Current Opinion in Structural Biology, 1995
In the past year, the atomic structures of three fragments of type I DNA topoisomerases were elucidated. Together with the atomic structure of a fragment of bacterial gyrase, this wealth of structural information is helping to further our understanding of the mechanism of action of topoisomerases.
A, Sharma, A, Mondragón
openaire +2 more sources
In the past year, the atomic structures of three fragments of type I DNA topoisomerases were elucidated. Together with the atomic structure of a fragment of bacterial gyrase, this wealth of structural information is helping to further our understanding of the mechanism of action of topoisomerases.
A, Sharma, A, Mondragón
openaire +2 more sources
Alignment and phylogenetic analysis of type II DNA topoisomerases [PDF]
Journal of Biosciences, 1996 DNA topoisomerases have been evolved to solve the topological problems of DNA during replication, transcription, recombination and segregation. Discovery of several new enzymes and their characterization has necessitated this compilation.
Valakunja Nagaraja
exaly +4 more sources
Annual Review of Biochemistry, 1981
The various problems of disentangling DNA strands or duplexes in a cell are all rooted in the double-helical structure of DNA. Three distinct subfamilies of enzymes, known as the DNA topoisomerases, have evolved to solve these problems. This review focuses on work in the past decade on the mechanisms and cellular functions of these enzymes.
openaire +6 more sources
The various problems of disentangling DNA strands or duplexes in a cell are all rooted in the double-helical structure of DNA. Three distinct subfamilies of enzymes, known as the DNA topoisomerases, have evolved to solve these problems. This review focuses on work in the past decade on the mechanisms and cellular functions of these enzymes.
openaire +6 more sources