Results 141 to 150 of about 14,206 (239)

Update of the list of qualified presumption of safety (QPS) recommended microbiological agents intentionally added to food or feed as notified to EFSA 24: Suitability of taxonomic units notified to EFSA until March 2026

EFSA Journal, Volume 24, Issue 7, July 2026.
Abstract The Qualified Presumption of Safety (QPS) process was developed to provide a harmonised safety assessment approach to support EFSA Scientific Panels and Units. The QPS approach assesses the taxonomic identity, body of knowledge and safety of microorganisms intentionally added to the food and feed chain.
EFSA Panel on Biological Hazards (BIOHAZ), Ana Allende, Avelino Alvarez‐Ordóñez, Valeria Bortolaia, Sara Bover‐Cid, Alessandra De Cesare, Wietske Dohmen, Laurent Guillier, Liesbeth Jacxsens, Maarten Nauta, Lapo Mughini‐Gras, Jakob Ottoson, Luisa Peixe, Fernando Perez‐Rodriguez, Panagiotis Skandamis, Elisabetta Suffredini, Marianne Chemaly, Pier Sandro Cocconcelli, Pablo Salvador Fernández Escámez, Miguel Prieto Maradona, Amparo Querol, Lolke Sijtsma, Ingvar Sundh, Fulvio Barizzone, Marta Bisaschi, Sandra Correia, Lieve Herman   +26 more
wiley   +1 more source

Optimisation of a Novel Class of DNA Gyrase Inhibitors to Improve Antibacterial Activity

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
This article describes efforts to increase the antibacterial activity of a recently reported class of novel DNA gyrase inhibitors known as the isoquinoline sulphonamides by improving their uptake in bacterial cells. As antibiotic resistance continues to rise, the need for new antibacterials is clear.
Meg I. Ferguson, Cerissa C. van Walstijn, Vladyslav Lysenko, Marta A. Wilbrink, David Alencar Araripe, Jeroen M. Punt, Mario van der Stelt, Willem Jespers, Paolo Innocenti, Nathaniel I. Martin   +9 more
wiley   +1 more source

Local selection rules that can determine specific pathways of DNA unknotting by type II DNA topoisomerases

, 2017
We performed numerical simulations of DNA chains to understand how local geometry of juxtaposed segments in knotted DNA molecules can guide type II DNA topoisomerases to perform very efficient relaxation of DNA knots.
Weber, Cedric, Flammini, Alessandro, Burnier, Yannis, Stasiak, Andrzej   +3 more
core  

Type II DNA Topoisomerases Cause Spontaneous Double-Strand Breaks in Genomic DNA. [PDF]

Genes (Basel), 2019
Morimoto S, Tsuda M, Bunch H, Sasanuma H, Austin C, Takeda S.   +5 more
europepmc   +1 more source

Cellular DNA Topoisomerases Are Required for the Synthesis of Hepatitis B Virus Covalently Closed Circular DNA. [PDF]

J Virol, 2019
Sheraz M, Cheng J, Tang L, Chang J, Guo JT.   +4 more
europepmc   +1 more source

Rezatapopt and the Return of Targetable p53

MedComm, Volume 7, Issue 7, July 2026.
Yuanze Luo, Assam El‐Osta
wiley   +1 more source

An interbacterial cysteine protease toxin inhibits cell growth by targeting type II DNA topoisomerases GyrB and ParE. [PDF]

PLoS Biol
Song PY, Tsai CE, Chen YC, Huang YW, Chen PP, Wang TH, Hu CY, Chen PY, Ku C, Hsia KC, Ting SY.   +10 more
europepmc   +1 more source

Natural Compounds as Anticancer Agents Targeting DNA Topoisomerases. [PDF]

Curr Genomics, 2017
Jain CK, Majumder HK, Roychoudhury S.
europepmc   +1 more source

DNA topoisomerases of leishmania: modulation of functional activity and drug induced cell killing of the parasite

, 2011
There are a plethora of problems accompanying various transactions involving DNA and all are ultimately rooted to the bihelical geometry of this master molecule.
Sen Gupta, Souvik
core  

Experimental localization of metal-binding sites reveals the role of metal ions in type II DNA topoisomerases. [PDF]

Proc Natl Acad Sci U S A
Wang B, Najmudin S, Pan XS, Mykhaylyk V, Orr C, Wagner A, Govada L, Chayen NE, Fisher LM, Sanderson MR.   +9 more
europepmc   +1 more source