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Journal of Medicinal Chemistry, 2017
DNA topoisomerases constitute a large family of enzymes that are essential for all domains of life. Although they share general reaction chemistry and the capacity to govern DNA topology and resolve strand entanglements during fundamental molecular processes, they are characterized by differences in their structural organization, modes of enzymatic ...
CAPRANICO, GIOVANNI +2 more
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DNA topoisomerases constitute a large family of enzymes that are essential for all domains of life. Although they share general reaction chemistry and the capacity to govern DNA topology and resolve strand entanglements during fundamental molecular processes, they are characterized by differences in their structural organization, modes of enzymatic ...
CAPRANICO, GIOVANNI +2 more
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1992
Abstract DNA topoisomerases are a class of enzymes that modulate the topo logical structure of DNA. Since the discovery of the first topoisomerase 20 years ago (Wang 1971), many of the properties of this class of enzymes have been elucidated and this progress has been the subject of many reviews (Cozzarelli 1980; Gellert 1981; Liu 1983 ...
Jennifer Foste!, Linus L Shen
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Abstract DNA topoisomerases are a class of enzymes that modulate the topo logical structure of DNA. Since the discovery of the first topoisomerase 20 years ago (Wang 1971), many of the properties of this class of enzymes have been elucidated and this progress has been the subject of many reviews (Cozzarelli 1980; Gellert 1981; Liu 1983 ...
Jennifer Foste!, Linus L Shen
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DNA sequence selectivity of topoisomerases and topoisomerase poisons
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1998Chemical agents able to interfere with DNA topoisomerases are widespread in nature, and some of them have clinical efficacy as antitumor or antibacterial drugs. Drugs which have as a target DNA topoisomerases could be divided into two categories: poisons and catalytic inhibitors.
G, Capranico, M, Binaschi
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Structure of DNA topoisomerases
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1998Over the last several years topoisomerases have finally begun to yield to high-resolution structural studies. These models have greatly aided our understanding of the mechanisms of topoisomerase catalysis and drug interactions. This review will cover advances in the structural biology of topoisomerases and discuss their implications for topoisomerase ...
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Current Opinion in Structural Biology, 1998
Type II DNA topoisomerases are enzymes capable of passing one DNA duplex through another. A combination of structural and biochemical analyses is illuminating the mechanistic details of this transport reaction, revealing the sites of DNA and nucleotide binding and the existence of large-scale domain motions.
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Type II DNA topoisomerases are enzymes capable of passing one DNA duplex through another. A combination of structural and biochemical analyses is illuminating the mechanistic details of this transport reaction, revealing the sites of DNA and nucleotide binding and the existence of large-scale domain motions.
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Current Opinion in Oncology, 1993
The topology of DNA is regulated by DNA-topoisomerase enzymes, which induce either transient DNA single-strand breaks (topoisomerase I) or DNA double-strand breaks (topoisomerase II). The action of several anticancer drugs, eg, DNA intercalating agents (ie, anthracyclines, anthracenediones, anthrapyrazoles, amsacrines, and ellipticines) and ...
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The topology of DNA is regulated by DNA-topoisomerase enzymes, which induce either transient DNA single-strand breaks (topoisomerase I) or DNA double-strand breaks (topoisomerase II). The action of several anticancer drugs, eg, DNA intercalating agents (ie, anthracyclines, anthracenediones, anthrapyrazoles, amsacrines, and ellipticines) and ...
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1999
Assaying DNA Topoisomerase I Relaxation Activity Lance Stewart and James J. Champoux DNA Topoisomerase II-Catalyzed DNA Decatenation Andrea Haldane and Daniel M. Sullivan Plasmid DNA Supercoiling by DNA Gyrase Penny J. Sayer, Martin L. Goble, Mark Oram, and L.
Mary-Ann Bjornsti, Neil Osheroff
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Assaying DNA Topoisomerase I Relaxation Activity Lance Stewart and James J. Champoux DNA Topoisomerase II-Catalyzed DNA Decatenation Andrea Haldane and Daniel M. Sullivan Plasmid DNA Supercoiling by DNA Gyrase Penny J. Sayer, Martin L. Goble, Mark Oram, and L.
Mary-Ann Bjornsti, Neil Osheroff
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DNA Topoisomerases: Enzymes That Control DNA Conformation
1985It is common knowledge today that DNA molecules are not simple, rigid double helices, but molecules which have considerable conformational flexibility. This flexibility allows coiling of DNA into complex higher order structures. In most living cells or organelles, including many virus particles, these higher order structures occur on the basis of ...
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