Results 231 to 240 of about 2,307,592 (280)
Some of the next articles are maybe not open access.
1999
Assaying DNA Topoisomerase I Relaxation Activity Lance Stewart and James J. Champoux DNA Topoisomerase II-Catalyzed DNA Decatenation Andrea Haldane and Daniel M. Sullivan Plasmid DNA Supercoiling by DNA Gyrase Penny J. Sayer, Martin L. Goble, Mark Oram, and L.
Mary-Ann Bjornsti, Neil Osheroff
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Assaying DNA Topoisomerase I Relaxation Activity Lance Stewart and James J. Champoux DNA Topoisomerase II-Catalyzed DNA Decatenation Andrea Haldane and Daniel M. Sullivan Plasmid DNA Supercoiling by DNA Gyrase Penny J. Sayer, Martin L. Goble, Mark Oram, and L.
Mary-Ann Bjornsti, Neil Osheroff
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DNA Topoisomerases: Enzymes That Control DNA Conformation
1985It is common knowledge today that DNA molecules are not simple, rigid double helices, but molecules which have considerable conformational flexibility. This flexibility allows coiling of DNA into complex higher order structures. In most living cells or organelles, including many virus particles, these higher order structures occur on the basis of ...
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Current opinion in oncology, 1994
The topology of DNA is regulated by DNA-topoisomerase enzymes, which induce either transient DNA single-strand breaks (topoisomerase I) or DNA double-strand breaks (topoisomerase II). The action of several anticancer drugs, eg, DNA intercalating agents (ie, anthracyclines, anthracenediones, anthrapyrazoles, amsacrines, and ellipticines) and ...
G, Capranico +4 more
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The topology of DNA is regulated by DNA-topoisomerase enzymes, which induce either transient DNA single-strand breaks (topoisomerase I) or DNA double-strand breaks (topoisomerase II). The action of several anticancer drugs, eg, DNA intercalating agents (ie, anthracyclines, anthracenediones, anthrapyrazoles, amsacrines, and ellipticines) and ...
G, Capranico +4 more
openaire +5 more sources
DNA topoisomerases and topoisomerase inhibitors.
Pathologie-biologie, 1995DNA topoisomerases are ubiquitous nuclear enzymes, essential for several steps of DNA metabolism. They have recently been shown to be specific targets of a number of anticancer agents. In this review are discussed the most recent discoveries in the physiology and the molecular biology of DNA topoisomerases, and the mechanism of interaction with drugs ...
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[DNA topoisomerase inhibitor].
Nihon rinsho. Japanese journal of clinical medicine, 1994DNA topoisomerases are enzymes involved in various aspects of genetic processes by catalyzing a topological change of DNA. Topoisomerase is now viewed as an important cellular target of antitumor drugs. These drugs targeting topoisomerase have been used to establish a relationship between drug-induced cleavable complex formation and cytotoxicity ...
M, Hino, H, Niitani
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DNA Topoisomerases as Targets for Antibacterial Agents.
Methods in molecular biology, 2018H. Hiasa
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[DNA topoisomerase inhibitor].
Gan to kagaku ryoho. Cancer & chemotherapy, 1992CPT-11 and Topotecan are a new semisynthetic derivative of CPT, and have been shown to inhibit DNA topoisomerase I and to have a strong antitumor activity with low toxicity against murine tumor. On the other hard, the new antitumor compounds, NC-190 and IST-622 have been shown to inhibit DNA topoisomerase II, and the clinical study are currently under ...
T, Sugiura, Y, Ariyoshi
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Human topoisomerases and their roles in genome stability and organization
Nature Reviews Molecular Cell Biology, 2022Yves Pommier +2 more
exaly
New mechanistic and functional insights into DNA topoisomerases.
Annual Review of Biochemistry, 2013Stefanie H. Chen, N. Chan, T. Hsieh
semanticscholar +1 more source