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DNA Topoisomerases in Unicellular Pathogens: Structure, Function, and Druggability.
TIBS -Trends in Biochemical Sciences. Regular ed, 2019All organisms, including unicellular pathogens, compulsorily possess DNA topoisomerases for successful nucleic acid metabolism. But particular subtypes of topoisomerases exist, in all prokaryotes and in some unicellular eukaryotes, that are absent in ...
S. Chowdhury, H. Majumder
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2005
Abstract Virtually every reaction that occurs in biological systems is catalysed by an enzyme. The interconversions of the different topological forms of DNA are no exceptions. The enzymes that catalyse these processes are known as DNA topoisomerases and constitute a widespread and fascinating group.
Andrew D Bates, Anthony Maxwell
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Abstract Virtually every reaction that occurs in biological systems is catalysed by an enzyme. The interconversions of the different topological forms of DNA are no exceptions. The enzymes that catalyse these processes are known as DNA topoisomerases and constitute a widespread and fascinating group.
Andrew D Bates, Anthony Maxwell
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Current Opinion in Cell Biology, 1990
DNA topoisomerases play an important role in regulating DNA structure, thus affecting many aspects of chromosome function inside cells. Recent progress in this field raises exciting questions regarding the distinct and critical functions of multiple topoisomerases, and the roles of DNA topoisomerases in the processes of chromosome condensation ...
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DNA topoisomerases play an important role in regulating DNA structure, thus affecting many aspects of chromosome function inside cells. Recent progress in this field raises exciting questions regarding the distinct and critical functions of multiple topoisomerases, and the roles of DNA topoisomerases in the processes of chromosome condensation ...
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1992
Abstract DNA topoisomerases are a class of enzymes that modulate the topo logical structure of DNA. Since the discovery of the first topoisomerase 20 years ago (Wang 1971), many of the properties of this class of enzymes have been elucidated and this progress has been the subject of many reviews (Cozzarelli 1980; Gellert 1981; Liu 1983 ...
Jennifer Foste!, Linus L Shen
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Abstract DNA topoisomerases are a class of enzymes that modulate the topo logical structure of DNA. Since the discovery of the first topoisomerase 20 years ago (Wang 1971), many of the properties of this class of enzymes have been elucidated and this progress has been the subject of many reviews (Cozzarelli 1980; Gellert 1981; Liu 1983 ...
Jennifer Foste!, Linus L Shen
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DNA sequence selectivity of topoisomerases and topoisomerase poisons
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1998Chemical agents able to interfere with DNA topoisomerases are widespread in nature, and some of them have clinical efficacy as antitumor or antibacterial drugs. Drugs which have as a target DNA topoisomerases could be divided into two categories: poisons and catalytic inhibitors.
G, Capranico, M, Binaschi
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Molecular Pharmacology, 1990
The effect of cyanomorpholinyldoxorubicin, morpholinyldoxorubicin, doxorubicin, and Actinomycin D were studied on purified mouse leukemia (L1210) DNA topoisomerases I and II. DNA unwinding and cross-linking were also studied.
K. Wassermann +5 more
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The effect of cyanomorpholinyldoxorubicin, morpholinyldoxorubicin, doxorubicin, and Actinomycin D were studied on purified mouse leukemia (L1210) DNA topoisomerases I and II. DNA unwinding and cross-linking were also studied.
K. Wassermann +5 more
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Structure of DNA topoisomerases
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1998Over the last several years topoisomerases have finally begun to yield to high-resolution structural studies. These models have greatly aided our understanding of the mechanisms of topoisomerase catalysis and drug interactions. This review will cover advances in the structural biology of topoisomerases and discuss their implications for topoisomerase ...
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Current Opinion in Structural Biology, 1998
Type II DNA topoisomerases are enzymes capable of passing one DNA duplex through another. A combination of structural and biochemical analyses is illuminating the mechanistic details of this transport reaction, revealing the sites of DNA and nucleotide binding and the existence of large-scale domain motions.
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Type II DNA topoisomerases are enzymes capable of passing one DNA duplex through another. A combination of structural and biochemical analyses is illuminating the mechanistic details of this transport reaction, revealing the sites of DNA and nucleotide binding and the existence of large-scale domain motions.
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Current Opinion in Oncology, 1993
The topology of DNA is regulated by DNA-topoisomerase enzymes, which induce either transient DNA single-strand breaks (topoisomerase I) or DNA double-strand breaks (topoisomerase II). The action of several anticancer drugs, eg, DNA intercalating agents (ie, anthracyclines, anthracenediones, anthrapyrazoles, amsacrines, and ellipticines) and ...
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The topology of DNA is regulated by DNA-topoisomerase enzymes, which induce either transient DNA single-strand breaks (topoisomerase I) or DNA double-strand breaks (topoisomerase II). The action of several anticancer drugs, eg, DNA intercalating agents (ie, anthracyclines, anthracenediones, anthrapyrazoles, amsacrines, and ellipticines) and ...
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