Results 211 to 220 of about 2,307,592 (280)
Some of the next articles are maybe not open access.
Journal of Medicinal Chemistry, 2017
DNA topoisomerases constitute a large family of enzymes that are essential for all domains of life. Although they share general reaction chemistry and the capacity to govern DNA topology and resolve strand entanglements during fundamental molecular processes, they are characterized by differences in their structural organization, modes of enzymatic ...
CAPRANICO, GIOVANNI +2 more
openaire +5 more sources
DNA topoisomerases constitute a large family of enzymes that are essential for all domains of life. Although they share general reaction chemistry and the capacity to govern DNA topology and resolve strand entanglements during fundamental molecular processes, they are characterized by differences in their structural organization, modes of enzymatic ...
CAPRANICO, GIOVANNI +2 more
openaire +5 more sources
DNA topoisomerases and DNA repair
BioEssays, 1988AbstractDNA topoisomerases are enzymes that can modify, and may regulate, the topological state of DNA through concerted breaking and rejoining of the DNA strands. They have been believed to be directly involved in DNA excision repair, and perhaps to be required for the control of repair as well. The vicissitudes of this hypothesis provide a noteworthy
C S, Downes, R T, Johnson
openaire +3 more sources
Cellular roles of DNA topoisomerases: a molecular perspective
Nature Reviews Molecular Cell Biology, 2002James C. Wang
semanticscholar +3 more sources
Mechanistic Aspects of DNA Topoisomerases
Advances in Protein Chemistry, 1986Publisher Summary Topoisomerases are a diverse and important group of enzymes. Although attention has until recently been focused on their ability to interconvert DNA topoisomers, this does not necessarily constitute the primary biological function for all of them.
A, Maxwell, M, Gellert
openaire +3 more sources
DNA topoisomerases: structure, function, and mechanism.
Annual Review of Biochemistry, 2001J. Champoux
semanticscholar +3 more sources
Current Opinion in Structural Biology, 1995
In the past year, the atomic structures of three fragments of type I DNA topoisomerases were elucidated. Together with the atomic structure of a fragment of bacterial gyrase, this wealth of structural information is helping to further our understanding of the mechanism of action of topoisomerases.
A, Sharma, A, Mondragón
openaire +2 more sources
In the past year, the atomic structures of three fragments of type I DNA topoisomerases were elucidated. Together with the atomic structure of a fragment of bacterial gyrase, this wealth of structural information is helping to further our understanding of the mechanism of action of topoisomerases.
A, Sharma, A, Mondragón
openaire +2 more sources
Annual Review of Biochemistry, 1981
The various problems of disentangling DNA strands or duplexes in a cell are all rooted in the double-helical structure of DNA. Three distinct subfamilies of enzymes, known as the DNA topoisomerases, have evolved to solve these problems. This review focuses on work in the past decade on the mechanisms and cellular functions of these enzymes.
openaire +6 more sources
The various problems of disentangling DNA strands or duplexes in a cell are all rooted in the double-helical structure of DNA. Three distinct subfamilies of enzymes, known as the DNA topoisomerases, have evolved to solve these problems. This review focuses on work in the past decade on the mechanisms and cellular functions of these enzymes.
openaire +6 more sources
Structure, molecular mechanisms, and evolutionary relationships in DNA topoisomerases.
Annual Review of Biophysics and Biomolecular Structure, 2004K. Corbett, J. Berger
semanticscholar +3 more sources