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Drugs Acting on DNA Topoisomerases: Recent Advances and Future Perspectives

Current Pharmaceutical Design, 1999
DNA-topoisomerases, a family of DNA-processing enzymes, represent the pharmacological target of major clinically useful chemotherapeutic agents. These drugs essentially act by trapping a topoisomerase-DNA cleavable complex, an intermediate in the enzyme ...
Barbara Gatto, Manlio Palumbo
exaly   +1 more source

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Basis for the discrimination of supercoil handedness during DNA cleavage by human and bacterial type II topoisomerases

Nucleic Acids Research, 2023
Keir C. Neuman, Neil Osheroff, Jeffrey Jian   +2 more
exaly  

Emerging roles of DNA topoisomerases in the regulation of R-loops

Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 2022
Razq Hakem, Parasvi S Patel
exaly  

Cellular roles of DNA topoisomerases: a molecular perspective

Nature Reviews Molecular Cell Biology, 2002
James C Wang
exaly  

A Bacterial Chromosome Structuring Protein Binds Overtwisted DNA to Stimulate Type II Topoisomerases and Enable DNA Replication

Cell, 2018
Maria A. Schumacher, Monica S Guo, Laub MT   +2 more
exaly  

Separation and functional analysis of eukaryotic DNA topoisomerases by chromatography and electrophoresis

Journal of Chromatography B, Biomedical Sciences and Applications, 1996
Tobias Straub, Friedrich Boege, Birgitta Ruth Knudsen   +2 more
exaly  

Antitumor Inhibitors of DNA Topoisomerases

Current Pharmaceutical Design, 1995
Giovanni Capranico, F Zunino
exaly  

Roles of eukaryotic topoisomerases in transcription, replication and genomic stability

Nature Reviews Molecular Cell Biology, 2016
John L. Nitiss, Yves Pommier, Yilun Sun
exaly  

Structure and mechanism of action of type IA DNA topoisomerases

Biochemistry (Moscow), 2010
Georgy Nevinsky, D V Bugreev
exaly  

DNA Topoisomerases

Transcription, 2013
Laura Baranello, David Levens, Fedor Kouzine   +2 more
exaly