Results 191 to 200 of about 14,206 (239)
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Current Opinion in Structural Biology, 1995
In the past year, the atomic structures of three fragments of type I DNA topoisomerases were elucidated. Together with the atomic structure of a fragment of bacterial gyrase, this wealth of structural information is helping to further our understanding of the mechanism of action of topoisomerases.
A, Sharma, A, Mondragón
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In the past year, the atomic structures of three fragments of type I DNA topoisomerases were elucidated. Together with the atomic structure of a fragment of bacterial gyrase, this wealth of structural information is helping to further our understanding of the mechanism of action of topoisomerases.
A, Sharma, A, Mondragón
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Annual Review of Biochemistry, 1981
The various problems of disentangling DNA strands or duplexes in a cell are all rooted in the double-helical structure of DNA. Three distinct subfamilies of enzymes, known as the DNA topoisomerases, have evolved to solve these problems. This review focuses on work in the past decade on the mechanisms and cellular functions of these enzymes.
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The various problems of disentangling DNA strands or duplexes in a cell are all rooted in the double-helical structure of DNA. Three distinct subfamilies of enzymes, known as the DNA topoisomerases, have evolved to solve these problems. This review focuses on work in the past decade on the mechanisms and cellular functions of these enzymes.
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DNA topoisomerases and DNA repair
BioEssays, 1988AbstractDNA topoisomerases are enzymes that can modify, and may regulate, the topological state of DNA through concerted breaking and rejoining of the DNA strands. They have been believed to be directly involved in DNA excision repair, and perhaps to be required for the control of repair as well. The vicissitudes of this hypothesis provide a noteworthy
C S, Downes, R T, Johnson
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DNA sequence selectivity of topoisomerases and topoisomerase poisons
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1998Chemical agents able to interfere with DNA topoisomerases are widespread in nature, and some of them have clinical efficacy as antitumor or antibacterial drugs. Drugs which have as a target DNA topoisomerases could be divided into two categories: poisons and catalytic inhibitors.
G, Capranico, M, Binaschi
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Drugs Acting on DNA Topoisomerases: Recent Advances and Future Perspectives
Current Pharmaceutical Design, 1999 DNA-topoisomerases, a family of DNA-processing enzymes, represent the pharmacological target of major clinically useful chemotherapeutic agents. These drugs essentially act by trapping a topoisomerase-DNA cleavable complex, an intermediate in the enzyme ...
Barbara Gatto, Manlio Palumbo
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Current Opinion in Cell Biology, 1990
DNA topoisomerases play an important role in regulating DNA structure, thus affecting many aspects of chromosome function inside cells. Recent progress in this field raises exciting questions regarding the distinct and critical functions of multiple topoisomerases, and the roles of DNA topoisomerases in the processes of chromosome condensation ...
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DNA topoisomerases play an important role in regulating DNA structure, thus affecting many aspects of chromosome function inside cells. Recent progress in this field raises exciting questions regarding the distinct and critical functions of multiple topoisomerases, and the roles of DNA topoisomerases in the processes of chromosome condensation ...
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Structure of DNA topoisomerases
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1998Over the last several years topoisomerases have finally begun to yield to high-resolution structural studies. These models have greatly aided our understanding of the mechanisms of topoisomerase catalysis and drug interactions. This review will cover advances in the structural biology of topoisomerases and discuss their implications for topoisomerase ...
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2005
Abstract Virtually every reaction that occurs in biological systems is catalysed by an enzyme. The interconversions of the different topological forms of DNA are no exceptions. The enzymes that catalyse these processes are known as DNA topoisomerases and constitute a widespread and fascinating group.
John L. Nitiss, Alexander Stepanov
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Abstract Virtually every reaction that occurs in biological systems is catalysed by an enzyme. The interconversions of the different topological forms of DNA are no exceptions. The enzymes that catalyse these processes are known as DNA topoisomerases and constitute a widespread and fascinating group.
John L. Nitiss, Alexander Stepanov
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The mechanisms of DNA topoisomerases
Trends in Biochemical Sciences, 1995Recent structural and mechanistic studies, as well as the discovery of new enzymes in the DNA topoisomerase family, allow these enzymes to be classified into three groups. Each group reflects the evolution of three different mechanistic strategies to manipulate DNA topology.
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1992
Abstract DNA topoisomerases are a class of enzymes that modulate the topo logical structure of DNA. Since the discovery of the first topoisomerase 20 years ago (Wang 1971), many of the properties of this class of enzymes have been elucidated and this progress has been the subject of many reviews (Cozzarelli 1980; Gellert 1981; Liu 1983 ...
Jennifer Foste!, Linus L Shen
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Abstract DNA topoisomerases are a class of enzymes that modulate the topo logical structure of DNA. Since the discovery of the first topoisomerase 20 years ago (Wang 1971), many of the properties of this class of enzymes have been elucidated and this progress has been the subject of many reviews (Cozzarelli 1980; Gellert 1981; Liu 1983 ...
Jennifer Foste!, Linus L Shen
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