Results 201 to 210 of about 14,206 (239)
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Resistance to inhibitors of DNA topoisomerases
1991Studies examining the mechanisms of resistance to camptothecin and its water-soluble analogs have been reported only recently. None of these studies have involved resistance derived in vivo in humans. Some of the mechanisms already describe could be predicted from the mechanism of action of the drug and from prior studies in yeast.
D M, Sullivan, W E, Ross
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Mechanistic Aspects of DNA Topoisomerases
1986Publisher Summary Topoisomerases are a diverse and important group of enzymes. Although attention has until recently been focused on their ability to interconvert DNA topoisomers, this does not necessarily constitute the primary biological function for all of them.
A, Maxwell, M, Gellert
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Structure and Mechanism of DNA Topoisomerases
Annual Review of Biophysics and Biomolecular Structure, 1995DNA topoisomerases are ubiquitous enzymes that control the level of supercoiling of DNA in cells. There are several classes, each with distinct properties, which are briefly discussed in this review. High-resolution X-ray crystallographic structures have been obtained for fragments of two classes of these enzymes, which when combined with biochemical ...
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DNA topoisomerases and topoisomerase inhibitors.
Pathologie-biologie, 1995DNA topoisomerases are ubiquitous nuclear enzymes, essential for several steps of DNA metabolism. They have recently been shown to be specific targets of a number of anticancer agents. In this review are discussed the most recent discoveries in the physiology and the molecular biology of DNA topoisomerases, and the mechanism of interaction with drugs ...
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DNA Topoisomerases: Enzymes That Control DNA Conformation
1985It is common knowledge today that DNA molecules are not simple, rigid double helices, but molecules which have considerable conformational flexibility. This flexibility allows coiling of DNA into complex higher order structures. In most living cells or organelles, including many virus particles, these higher order structures occur on the basis of ...
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Current Opinion in Structural Biology, 1998
Type II DNA topoisomerases are enzymes capable of passing one DNA duplex through another. A combination of structural and biochemical analyses is illuminating the mechanistic details of this transport reaction, revealing the sites of DNA and nucleotide binding and the existence of large-scale domain motions.
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Type II DNA topoisomerases are enzymes capable of passing one DNA duplex through another. A combination of structural and biochemical analyses is illuminating the mechanistic details of this transport reaction, revealing the sites of DNA and nucleotide binding and the existence of large-scale domain motions.
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DNA Topoisomerases and Radiation Responses
International Journal of Radiation Biology, 1990This review primarily addresses recent studies on the enzymes topoisomerase I and topoisomerase II, found in mammalian cells, and their importance in cellular responses to ...
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DNA topoisomerases as targets for chemotherapy
The FASEB Journal, 1988DNA topoisomerases are ubiquitous enzymes that alter the configuration or topology of DNA. These enzymes play an important role in replicational, recombinational, and transcriptional events and are a key to cell growth processes.
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