Results 31 to 40 of about 28,674 (272)

Anti-topoisomerase drugs as potent inducers of chromosomal aberrations

Genetics and Molecular Biology, 2000
DNA topoisomerases catalyze topological changes in DNA that are essential for normal cell cycle progression and therefore they are a preferential target for the development of anticancer drugs.
Loredana Bassi, Fabrizio Palitti
doaj   +1 more source

Atomic force microscopy shows that vaccinia topoisomerase IB generates filaments on DNA in a cooperative fashion [PDF]

, 2005
Type IB DNA topoisomerases cleave and rejoin one strand of the DNA duplex, allowing for the removal of supercoils generated during replication and transcription.
Dekker, Cees, Dekker, Nynke H., Holtzer, Laurent, Koster, Daniel A., Moreno-Herrero, Fernando, Shuman, Stewart   +5 more
core   +2 more sources

Crystallization and preliminary crystallographic analysis of the DNA gyrase B protein from B-stearothermophilus [PDF]

, 1996
DNA gyrase B (GyrB) from B. stearothermophilus has been crystallized in the presence of the non-hydrolyzable ATP analogue, 5'-adenylpl-beta-gamma-imidodiphosphate (ADPNP), by the dialysis method.
Brannigan, J A, Subramanya, H S, Tsai, F T F, Wigley, D B, Wilkinson, A J   +4 more
core   +2 more sources

TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1 [PDF]

, 2012
The abortive activity of topoisomerases can result in clastogenic and/or lethal DNA damage in which the topoisomerase is covalently linked to the 3'- or 5'-terminus of a DNA strand break. This type of DNA damage is implicated in chromosome translocations
Abhishek Sharma, Barthelmes, Danny Huylebroeck, Davies, Davies, El-Khamisy, El-Khamisy, El-Khamisy, El-Khamisy, Esguerra, Giovanella, Hirano, Hudson, Interthal, Interthal, Junko Murai, Katyal, Keith W. Caldecott, Ledesma, Liesbeth Vermeire, Lieve Umans, Limei Ju, Murai, Nitiss, Pommier, Pommier, Pype, Sherif F. El-Khamisy, Shunichi Takeda, Takashima, Varady, Vilotti, Yang, Yves Pommier, Zeng, Zhihong Zeng, Zhou   +36 more
core   +1 more source

DNA Topoisomerases [PDF]

Transcription, 2013
Chromatin is dynamically changing its structure to accommodate and control DNA-dependent processes inside of eukaryotic cells. These changes are necessarily linked to changes of DNA topology, which might itself serve as a regulatory signal to be detected by proteins.
Laura, Baranello, Fedor, Kouzine, David, Levens   +2 more
openaire   +2 more sources

Determination of the Primary Molecular Target of 1,2,4-Triazole-Ciprofloxacin Hybrids [PDF]

, 2015
We have synthesized and examined the antibacterial activity, toxicity and affinity towards bacterial type II topoisomerases of a series of 1,2,4-triazole-ciprofloxacin hybrids.
Agata Paneth, Aleksandra Strzelczyk, Anna Malm, Barbara Kaproń, Barbara Rajtar, Dalhoff, Małgorzata Polz-Dacewicz, Oliphant, Paweł Stączek, Sharma, Tomasz Plech, Urszula Kosikowska, Łukasz Świątek   +12 more
core   +2 more sources

DNA topoisomerase inhibitors: biflavonoids from Ouratea species

Brazilian Journal of Medical and Biological Research, 2002
Topoisomerase inhibitors are agents with anticancer activity. 7"-O-Methyl-agathisflavone (I) and amentoflavone (II) are biflavonoids and were isolated from the Brazilian plants Ouratea hexasperma and O. semiserrata, respectively.
N.F. Grynberg, M.G. Carvalho, J.R. Velandia, M.C. Oliveira, I.C. Moreira, R. Braz- Filho, A. Echevarria   +6 more
doaj   +1 more source

“Breaking up is hard to do”: the formation and resolution of sister chromatid intertwines [PDF]

, 2014
The absolute necessity to resolve every intertwine between the two strands of the DNA double helix provides a massive challenge to the cellular processes that duplicate and segregate chromosomes.
Bartkova, Baumann, Baxter, Baxter, Baxter, Bermejo, Bester, Branzei, Branzei, Brill, Burrell, Bzymek, Cejka, Champoux, Champoux, Chan, Chan, Chang, Chu, Crisona, Cuylen, Cuylen, Delbrück, Di Micco, Dominguez-Sola, Ekholm-Reed, Farcas, Fernandez, Gandhi, Gangloff, Gerlich, Germann, Giet, Goodwin, Gorgoulis, Halazonetis, Hardy, Hawkins, Hendzel, Hiasa, Hiasa, Hiasa, Hills, Hirano, Hirano, Hirano, Holm, Hsu, Jonathan Baxter, Kato, Kato, Khodursky, Khodursky, Kimura, Kimura, Kitamura, Koshland, Kreuzer, Kueng, Lavoie, Leman, Lucas, Mantiero, Maresca, Marston, Martinez-Robles, Matos, McClendon, McClintock, McGlynn, McGuffee, Mullen, Naughton, Neelsen, Newport, Oliveira, Ono, Paulson, Peter, Postow, Rattner, Rybenkov, Rybenkov, Sakaguchi, Samejima, Schoeffler, Schvartzman, Shamu, Shintomi, Spruck, Stuchinskaya, Sullivan, Sundin, Sundin, Suski, Symington, Szakal, Tedeschi, Temime-Smaali, Toledo, Vologodskii, Vos, Wang, Wang, Wang, Watson, Watson, Wei, Wilkins, Zechiedrich, Zechiedrich   +110 more
core   +1 more source

Topoisomerase IIα represses transcription by enforcing promoter-proximal pausing

Cell Reports, 2021
Summary: Accumulation of topological stress in the form of DNA supercoiling is inherent to the advance of RNA polymerase II (Pol II) and needs to be resolved by DNA topoisomerases to sustain productive transcriptional elongation.
Andrés Herrero-Ruiz, Pedro Manuel Martínez-García, José Terrón-Bautista, Gonzalo Millán-Zambrano, Jenna Ariel Lieberman, Silvia Jimeno-González, Felipe Cortés-Ledesma   +6 more
doaj   +1 more source

Structural basis for allosteric regulation of Human Topoisomerase IIα

Nature Communications, 2021
Type 2 DNA topoisomerases (Top2) regulates DNA topology during DNA replication, transcription, and chromosome segregation. Here the authors describe a complete structure of the catalytic core of the human Topo IIα bound to DNA and etoposide, providing ...
Arnaud Vanden Broeck, Christophe Lotz, Robert Drillien, Léa Haas, Claire Bedez, Valérie Lamour   +5 more
doaj   +1 more source