Results 61 to 70 of about 28,674 (272)

Knotting probabilities after a local strand passage in unknotted self-avoiding polygons

, 2011
We investigate the knotting probability after a local strand passage is performed in an unknotted self-avoiding polygon on the simple cubic lattice.
Bates A, Berg B, Berger J M, Berretti A, Buck G, Burnier Y, C E Soteros, Clisby N, de Carvalho C A, de Carvalho C A, Fishman G S, Fogg J M, Gelman A, Gelman A, Guttmann A J, Hua X, Janse van Rensburg E J, Janse van Rensburg E J, Janse van Rensburg E J, Janse van Rensburg E J, Liu Z, Liu Z, Liu Z, Liu Z R, M L Szafron, Manturov V, Marcone B, Orlandini E, Orlandini E, Orlandini E, Rybenkov V V, Shaw S Y, Sokal A D, Sumners D W, Szafron M L, Szafron M L, Trigueros S, Vologodskii A, Yan J   +38 more
core   +1 more source

Architecture of an All‐In‐One Microfluidic Platform for Accelerated Cancer Seeding, Enhanced Spheroid Formation, and Dynamic Drug Screening Trials

Advanced Materials Technologies, EarlyView.
An all‐in‐one microfluidic platform consists of two‐layered PDMS channels integrated with a hydrogel microwell array. This platform enables flow‐driven tumor cell capture, enhanced spheroid formation within the microwells, and advective drug testing. ABSTRACT Effective cancer drug screening requires platforms that replicate the physiological complexity
Omar M. Rahman, Shengxi Lan, Dae Kun Hwang   +2 more
wiley   +1 more source

Clinical Significance of Expression of Topoisomerase 2а in Breast Cancer

Антибиотики и Химиотерапия, 2020
Topoisomerases are enzymes that control the topology of DNA. Topoisomerases are divided into types 1 and 2, depending on the mechanism of action. The article discusses the structure and mechanisms of the action of topoisomerases, the possibility of an ...
A. A. Samuseva, R. V. Lyubota, A. S. Zotov, R. I. Vereshchako   +3 more
doaj  

Topoisomerases inhibition and DNA binding mode of daunomycin–oligoarginine conjugate

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Cancer is a major health issue adsorbing the attention of a biomedical research. To fight this disease, new drugs are developed, specifically tailored to target biological pathways or peculiar components of the tumour cells.
Valeria Visone, Ildikó Szabó, Giuseppe Perugino, Ferenc Hudecz, Zoltán Bánóczi, Anna Valenti   +5 more
doaj   +1 more source

Fluorescently labeled circular DNA molecules for DNA topology and topoisomerases [PDF]

, 2016
DNA topology plays essential roles in several fundamental biological processes, such as DNA replication, recombination, and transcription. Typically agarose gel electrophoresis is employed to study DNA topology.
Berrido, Andrea, Chambers, Jeremy W., Gonzalez, Walter, Gu, Maxwell, Leng, Fenfei, Miksovska, Jaroslava   +5 more
core   +1 more source

RIG‐I Mediated Neuron‐Specific IFN Type 1 Signaling in FUS‐ALS Induces Neurodegeneration and Offers New Biomarker‐Driven Individualized Treatment Options for (FUS‐)ALS

Advanced Science, EarlyView.
Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann, Theresa M. Wierschin, Stefanie Kretschmer, Banaja P. Dash, Aaron Held, Andrea Salzinger, Kevin Peikert, Anže Karlek, Hannes Glaß, Dajana Großmann, René Günther, Susanne Petri, Annekathrin Rödiger, David Brenner, Francisco Pan‐Montojo, Eleonora Aronica, Markus Kipp, Vitaly Zimyanin, Jared Sterneckert, Torsten Grehl, Noah D. Seebacher, Tobias M. Böckers, Alberto Catanese, Brian J. Wainger, Patrick Oeckl, Min Ae Lee‐Kirsch, Andreas Hermann   +26 more
wiley   +1 more source

DNA unzipped under a constant force exhibits multiple metastable intermediates [PDF]

, 2003
Single molecule studies, at constant force, of the separation of double-stranded DNA into two separated single strands may provide information relevant to the dynamics of DNA replication.
Bockelmann, Bustamante, Bustamante, C. Bouzigues, C. Danilowicz, D. K. Lubensky, D. R. Nelson, Essevaz-Roulet, Gosse, Isralewitz, Le Doussal, Liphardt, Lubensky, M. Prentiss, Marenduzzo, M  chali, Quake, Rief, Rouzina, SantaLucia, Sebastian, Smith, Strick, Strick, Thomen, V. W. Coljee, Vermeer   +26 more
core   +2 more sources

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

Topoisomerases and cancer chemotherapy: recent advances and unanswered questions [version 1; peer review: 3 approved]

F1000Research, 2019
DNA topoisomerases are enzymes that catalyze changes in the torsional and flexural strain of DNA molecules. Earlier studies implicated these enzymes in a variety of processes in both prokaryotes and eukaryotes, including DNA replication, transcription ...
Mary-Ann Bjornsti, Scott H. Kaufmann
doaj   +1 more source

ZNRD2 Mediated Nucleoprotein Aggregation Impairs Respiratory Syncytial Virus Replication

Advanced Science, EarlyView.
During RSV infection, nucleoprotein (N) forms RNA‐bound oligomers. The host protein ZNRD2 binds to these oligomers, promoting their transition into insoluble aggregates. These aggregates simultaneously sequester functional N to restrict viral production and disrupt chaperonin assembly quality control by interfering with ZNRD2's role as an adaptor ...
Haiwu Zhou, Mingbin He, Jinhong Du, Cong Liu, Weiwei Wang, Yuewen Han, Zhifei Li, Yali Qin, Mingzhou Chen   +8 more
wiley   +1 more source