Results 11 to 20 of about 92,871 (296)

Regulation of transposable elements by DNA modifications [PDF]

Nature Reviews Genetics, 2019
Maintenance of genome stability requires control over the expression of transposable elements (TEs), whose activity can have substantial deleterious effects on the host. Chemical modification of DNA is a commonly used strategy to achieve this, and it has long been argued that the emergence of 5-methylcytosine (5mC) in many species was driven by the ...
Özgen Deniz, Jennifer M. Frost, Miguel R. Branco   +2 more
openaire   +5 more sources

Regulatory transposable elements in the encyclopedia of DNA elements

Nature Communications, 2023
Transposable elements (TEs) comprise ~50% of our genome, but knowledge of how TEs affect genome evolution remains incomplete. Leveraging ENCODE4 data, we provide the most comprehensive study to date of TE contributions to the regulatory genome.
Alan Y. Du, Jason D. Chobirko, Xiaoyu Zhuo, Cédric Feschotte, Ting Wang   +4 more
doaj   +4 more sources

Detection of DNA Methylation Changes Surrounding Transposable Elements

Bio-Protocol, 2013
Transposable elements (TEs) are a major component of all genomes, thus the epigenetic mechanisms controlling their activity is an important field of study.
Beery Yaakov, Khalil Kashkush
doaj   +2 more sources

Small RNAs, DNA methylation and transposable elements in wheat [PDF]

BMC Genomics, 2010
Background More than 80% of the wheat genome is composed of transposable elements (TEs). Since active TEs can move to different locations and potentially impose a significant mutational load, their expression is suppressed in the genome via small non ...
Matvienko Marta, Dubcovsky Martin, Sumner Adam, Vanzetti Leonardo S, Cantu Dario, Distelfeld Assaf, Michelmore Richard W, Dubcovsky Jorge   +7 more
doaj   +6 more sources

DNA methylation enables transposable element-driven genome expansion [PDF]

Proceedings of the National Academy of Sciences, 2020
Significance We examined recent whole-genome data of 53 organisms and found that the substantial differences in their genome sizes can be largely explained by the proportion of transposable elements (TEs) within them. TEs coexist with their host largely because CpG methylation suppresses their transcription.
Wanding Zhou, Gangning Liang, Peter L. Molloy, Peter A. Jones   +3 more
openaire   +2 more sources

DNA on the move: mechanisms, functions and applications of transposable elements

FEBS Open Bio, 2023
Transposons are mobile genetic elements that have invaded all domains of life by moving between and within their host genomes. Due to their mobility (or transposition), transposons facilitate horizontal gene transfer in bacteria and foster the evolution ...
Michael Schmitz, Irma Querques
doaj   +3 more sources

Mobilization of DNA transposable elements from lentiviral vectors [PDF]

Mobile Genetic Elements, 2011
With the Sleeping Beauty (SB) DNA transposon, a reconstructed Tc1/mariner element, as the driving force, DNA transposable elements have emerged as new gene delivery vectors with therapeutic potential. The bipartite transposon vector system consists of a transposon vector carrying the transgene and a source of the transposase that catalyzes transposon ...
Bak, Rasmus Otkjær, Mikkelsen, Jacob Giehm   +1 more
openaire   +3 more sources

Transposable elements and circular DNAs [PDF]

Mobile Genetic Elements, 2016
Circular DNAs are extra-chromosomal fragments that become circularized by genomic recombination events. We have recently shown that yeast LTR elements generate circular DNAs through recombination events between their flanking long terminal repeats (LTRs).
openaire   +3 more sources

The CACTA transposon Bot1 played a major role in Brassica genome divergence and gene proliferation [PDF]

, 2008
We isolated and characterized a Brassica C genome-specific CACTA element, which was designated Bot1 (Brassica oleracea transposon 1). After analysing phylogenetic relationships, copy numbers and sequence similarity of Bot1 and Bot1 analogues in B ...
AGI, Arabidopsis Genome Initiative, Alix, Alix, Alix, Bandelt, Bateman, Bennetzen, Brunner, Casacuberta, Cui, Darling, DeMarco, Deragon, Edgar, Eichler, Fedoroff, Feschotte, Gaeta, Gish, Grandbastien, Hawkins, He, Heslop-Harrison, IHGSC, Inaba, Inagaki, Itoh, Jacobs, Jiang, Johnston, Kapitonov, Kapitonov, Kawasaki, Kazazian, Kubis, Kubis, Kuhn, Kurtz, Le, Leflon, Lenoir, Lysak, Maddison, Meyers, Miura, Morgante, Morgante, Nacken, Nicolas, Ozeki, O’Neill, Pereira, Peterson, Posada, Rocarro, Rodríguez, Schwarzacher, Shiba, Snowden, Snowdon, Sonnhammer, Strachan, Suzuki, Swofford, Talbert, Town, Turcotte, U, Vicient, Walbot, Wang, Wendel, Wicker, Wicker, Yang, Yang, Yu, Zabala, Zabala, Zhang, Zhang   +80 more
core   +1 more source

Transcriptome Analyses of Tumor-Adjacent Somatic Tissues Reveal Genes Co-Expressed with Transposable Elements [PDF]

, 2019
Background: Despite the long-held assumption that transposons are normally only expressed in the germ-line, recent evidence shows that transcripts of transposable element (TE) sequences are frequently found in the somatic cells.
Alberto, Adrian, Chung, Micky, Churchill, Daphnie, Clymer, Cody, Han, Mira V., Jonaid, G. M., Navarro Leija, Omar, Quinton, Sophia, Ross, Austin, Sexton, Corinne E.   +9 more
core   +2 more sources