Shedding light on DNA methylation and its clinical implications: the impact of long-read-based nanopore technology [PDF]
Epigenetics & ChromatinDNA methylation is an essential epigenetic mechanism for regulation of gene expression, through which many physiological (X-chromosome inactivation, genetic imprinting, chromatin structure and miRNA regulation, genome defense, silencing of transposable ...
Alexandra Chera +3 more
doaj +2 more sources
Evolutionary dynamics of transposable elements and satellite DNAs in polyploid Spartina species
Plant Science, 2020 Repeated sequences and polyploidy play a central role in plant genome dynamics. Here, we analyze the evolutionary dynamics of repeats in tetraploid and hexaploid Spartina species that diverged during the last 10 million years within the Chloridoideae, one of the poorest investigated grass lineages.
Delphine Giraud +9 more
openalex +9 more sources
Paired-End Mappability of Transposable Elements in the Human Genome [PDF]
Mobile DNA, 2019 Though transposable elements make up around half of the human genome, the repetitive nature of their sequences makes it difficult to accurately align conventional sequencing reads.
Han, Mira V., Sexton, Corinne E.
core +3 more sources
Functional Investigation of a Novel PIWIL4 Mutation in Nonobstructive Azoospermia During the First Wave of Spermatogenesis [PDF]
BiomoleculesPIWI-interacting RNAs (piRNAs) are small noncoding RNAs that are almost exclusively expressed in germ cells to silence harmful transposons to maintain genome stability. PIWIL4 is guided by its associated piRNAs to transposable elements, where it recruits
Xiayu Wang +8 more
doaj +2 more sources
Enhancer activation from transposable elements in extrachromosomal DNA
AbstractExtrachromosomal DNA (ecDNA) is a hallmark of aggressive cancer, contributing to both oncogene amplification and tumor heterogeneity. Here, we used Hi-C, super-resolution imaging, and long-read sequencing to explore the nuclear architecture ofMYC-amplified ecDNA in colorectal cancer cells.
Katerina Kraft +16 more
openalex +3 more sources
Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer [PDF]
, 2023 Transposable elements hold regulatory functions that impact cell fate determination by controlling gene expression. However, little is known about the transcriptional machinery engaged at transposable elements in pluripotent and mature versus oncogenic ...
Arlidge, Christopher +17 more
core +3 more sources
Genome sizes and repeatome evolution in zoantharians (Cnidaria: Hexacorallia: Zoantharia) [PDF]
PeerJ, 2023 Across eukaryotes, large variations of genome sizes have been observed even between closely related species. Transposable elements as part of the repeated DNA have been proposed and confirmed as one of the most important contributors to genome size ...
Chloé Julie Loïs Fourreau +7 more
doaj +2 more sources
Epigenetic dynamics during sexual reproduction: At the nexus of developmental control and genomic integrity. [PDF]
, 2022 Epigenetic marks influence gene regulation and genomic stability via the repression of transposable elements. During sexual reproduction, tight regulation of the epigenome must take place to maintain the repression of transposable elements while still ...
Jullien, Pauline E, Tirot, Louis
core +1 more source
Era-like GTP protein gene expression in rice
Brazilian Journal of Biology, 2021 The mutations are genetic changes in the genome sequences and have a significant role in biotechnology, genetics, and molecular biology even to find out the genome sequences of a cell DNA along with the viral RNA sequencing.
X. Zhou +8 more
doaj +1 more source
Pathogenic Tau Accelerates Aging-Associated Activation of Transposable Elements in the Mouse Central Nervous System [PDF]
, 2022 Transposable elements comprise almost half of the mammalian genome. A growing body of evidence suggests that transposable element dysregulation accompanies brain aging and neurodegenerative disorders, and that transposable element activation is ...
Beckmann, Adrian +13 more
core +2 more sources