Results 51 to 60 of about 93,119 (340)

Widespread contribution of transposable elements to the rewiring of mammalian 3D genomes

Nature Communications, 2023
Here the authors show transposable elements, formerly considered junk DNA, are a source of CTCF binding sites that contribute to species-specific 3D-genome structure, and may impact gene regulation during the course of mammalian evolution.
Mayank N. K. Choudhary, Kara Quaid, Xiaoyun Xing, Heather Schmidt, Ting Wang   +4 more
doaj   +1 more source

A new reference genome assembly for the microcrustacean Daphnia pulex [PDF]

, 2017
Comparing genomes of closely related genotypes from populations with distinct demographic histories can help reveal the impact of effective population size on genome evolution. For this purpose, we present a high quality genome assembly of Daphnia pulex (
Ackerman, Matthew S, Asselman, Jana, Harker, Brent, Jiang, Xiaoqian, Lopez, Jacqueline, Lynch, Michael, Pfrender, Michael E, Raborn, R Taylor, Ramsdell, Jordan, Spitze, Ken, Thomas, W Kelley, Xu, Sen, Ye, Zhiqiang   +12 more
core   +3 more sources

Shedding light on DNA methylation and its clinical implications: the impact of long-read-based nanopore technology

Epigenetics & Chromatin
DNA methylation is an essential epigenetic mechanism for regulation of gene expression, through which many physiological (X-chromosome inactivation, genetic imprinting, chromatin structure and miRNA regulation, genome defense, silencing of transposable ...
Alexandra Chera, Mircea Stancu-Cretu, Nicolae Radu Zabet, Octavian Bucur   +3 more
doaj   +1 more source

DNA methylation dynamics during early plant life

Genome Biology, 2017
Background Cytosine methylation is crucial for gene regulation and silencing of transposable elements in mammals and plants. While this epigenetic mark is extensively reprogrammed in the germline and early embryos of mammals, the extent to which DNA ...
Daniel Bouyer, Amira Kramdi, Mohamed Kassam, Maren Heese, Arp Schnittger, François Roudier, Vincent Colot   +6 more
doaj   +1 more source

Transposable Elements, Inflammation, and Neurological Disease. [PDF]

, 2019
Transposable Elements (TE) are mobile DNA elements that can replicate and insert themselves into different locations within the host genome. Their propensity to self-propagate has a myriad of consequences and yet their biological significance is not well-
Macia, Angela, Muotri, Alysson R, Saleh, Aurian   +2 more
core  

SUVH1, a Su(var)3-9 family member, promotes the expression of genes targeted by DNA methylation. [PDF]

, 2015
Transposable elements are found throughout the genomes of all organisms. Repressive marks such as DNA methylation and histone H3 lysine 9 (H3K9) methylation silence these elements and maintain genome integrity.
Chen, Xuemei, Gao, Lei, Kim, Yun Ju, Li, Shaofang, Li, Shengben, Liu, Lin, Zhao, Yuanyuan   +6 more
core   +2 more sources

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

The genomes of two key bumblebee species with primitive eusocial organization [PDF]

, 2015
Background: The shift from solitary to social behavior is one of the major evolutionary transitions. Primitively eusocial bumblebees are uniquely placed to illuminate the evolution of highly eusocial insect societies.
Amdam, Gro V., Antonio, David S. Marco, Aqrawi, Peshtewani K., Asher, Claire, Barribeau, Seth M., Beckers, Matthew, Bennett, Anna K., Beye, Martin, Biewer, Matthias, Bitondi, Márcia M. G., Blankenburg, Kerstin P., Blaxter, Mark L., Bloch, Guy, Blommaert, Julie, Bornberg-Bauer, Erich, Bourke, Andrew F. G., Brown, Mark J. F., Buechel, Severine D., Cameron, Rossanah, Cappelle, Kaat, Carolan, James C., Chipman, Ariel D., Chittka, Lars, Christiaens, Olivier, Ciborowski, Kate L., Clarke, David F., Colgan, Thomas J., Collins, David H., Coyle, Marcus, Cridge, Andrew G., Câmara, Francisco, Dalmay, Tamas, de Graaf, Dirk C., Dearden, Peter, Debyser, Griet, Devreese, Bart, Dreier, Stephanie, du Plessis, Louis, Duncan, Elizabeth, Elsik, Christine G., Erler, Silvio, Evans, Jay, Falcon, Tiago, Flores, Kevin, Fouks, Bertrand, Francisco, Liezl, Freitas, Flávia C. P., Fuchikawa, Taro, Gadau, Jürgen, Gempe, Tanja, Gibbs, Richard A., Grimmelikhuijzen, Cornelis J. P., Guigó, Roderic, Hartfelder, Klaus, Hasselmann, Martin, Hauser, Frank, Helbing, Sophie, Hernandez, Alvaro G., Hoff, Katharina, Holder, Michael, Hudson, Matthew E., Humann, Fernanda C., Irvine, Frano, Jackson, Laronda, Jayaseelan, Joy, Jermiin, Lars S., Johnson, Claire E., Johnson, Reed M., Jones, Andrew K., Joshi, Vandita, Kadowaki, Tatsuhiko, Kidner, Jonathan H., Klasberg, Steffen, Koch, Vasco, Kovar, Christie, Kraus, F Bernhard, Köhler, Arian, Lattorff, H. Michael G., Leask, Megan, Lee, Sandra L., Liu, Jisheng, Lockett, Gabrielle A., Lozier, Jeffrey D., Mallon, Eamonn B., Mariotti, Marco, Marxer, Monika, Mata, Robert, Mathew, Tittu, Meeus, Ivan, Moritz, Robin F. A., Munoz-Torres, Monica, Murphy, Terence, Muzny, Donna M., Nair, Ajay, Newsham, Irene F., Ngo, Robin, Nissen, Inga, Niu, Jinzhi, Nunes, Francis M. F., Näpflin, Kathrin, O'Neill, Meaghan P., Oakeshott, John G., Okwuonu, Geoffrey, Osborne, Amy, Otte, Marianne, Pham, Christopher, Pinheiro, Daniel G., Pu, Ling-Ling, Puiu, Daniela, Qu, Jiaxin, Richards, Stephen, Robertson, Hugh M., Robinson, Gene E., Rossié, Nina, Rueppell, Olav, Saada, Nehad, Sadd, Ben M., Salzberg, Steven L., Santesmasses, Didac, Santibanez, Jireh, Santos, Carolina G., Scherer, Steven E., Schmid-Hempel, Paul, Schmid-Hempel, Regula, Schmitt, Björn D., Schulte, Christina, Simmons, Denard, Simões, Zilá Lp, Smagghe, Guy, Soares, Michelle P. M., Stolle, Eckart, Sumner, Seirian, Swevers, Luc, Thornton, Rebecca, van Vaerenbergh, Matthias, Venkat, Aarti, Walden, Kimberly K. O., Waterhouse, Robert M., Winnebeck, Eva C., Wolschin, Florian, Worley, Kim C., Wu, Yuan-Qing, Yu, Na, Zdobnov, Evgeny M.   +143 more
core   +16 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Cross-Regulation between Transposable Elements and Host DNA Replication [PDF]

Viruses, 2017
Transposable elements subvert host cellular functions to ensure their survival. Their interaction with the host DNA replication machinery indicates that selective pressures lead them to develop ancestral and convergent evolutionary adaptations aimed at conserved features of this fundamental process.
openaire   +2 more sources