Results 51 to 60 of about 167,159 (369)

Sensing of transposable elements by the antiviral innate immune system

RNA: A publication of the RNA Society, 2021
Around half of the genomes in mammals are composed of transposable elements (TEs) such as DNA transposons and retrotransposons. Several mechanisms have evolved to prevent their activity and the detrimental impact of their insertional mutagenesis. Despite
A. Gázquez-Gutiérrez, J. Witteveldt, Sara R Heras, Sara Macias   +3 more
semanticscholar   +1 more source

Transposable Elements: From DNA Parasites to Architects of Metazoan Evolution [PDF]

Genes, 2012
One of the most unexpected insights that followed from the completion of the human genome a decade ago was that more than half of our DNA is derived from transposable elements (TEs). Due to advances in high throughput sequencing technologies it is now clear that TEs comprise the largest molecular class within most metazoan genomes.
Oliver Piskurek, Daniel J. Jackson
openalex   +6 more sources

Nucleotide sequence of the transposable DNA-element IS2

Nucleic Acids Research, 1979
The complete sequence of the transposable DNA element IS2 in gal OP-308:: IS2 (I) has been determined. This element is 1.327 bp long. The integrated element is flanked by a five base pair long sequence duplication. The termini of IS2 are not perfect inverted repeats, but a close approximation.
D, Ghosal, H, Sommer, H, Saedler
openaire   +3 more sources

Characteristics of transposable element exonization within human and mouse [PDF]

, 2010
Insertion of transposed elements within mammalian genes is thought to be an important contributor to mammalian evolution and speciation. Insertion of transposed elements into introns can lead to their activation as alternatively spliced cassette exons ...
A Athanasiadis, A Corvelo, A Gerber, A Goren, A Levy, A Magen, A Nekrutenko, A Resch, AFA Smit, Agnes Hotz-Wagenblatt, B Giardine, B Mersch, BR Graveley, Britta Mersch, C Liu, D Karolchik, D Labuda, DD Kim, E Kim, ES Lander, EY Levanon, G Ast, G Lev-Maor, G Lev-Maor, Gil Ast, H Xie, Ilya Ruvinsky, J Hull, J Jurka, J Jurka, JO Kriegs, JO Yang, JP Nemes, K Nakabayashi, KP Kister, L Lin, L Lin, M Amit, M Blow, M Krull, M Moller-Krull, M Roy, M Sironi, M Sironi, MA Batzer, MD Koob, N Gal-Mark, N Gal-Mark, N Sela, NH Gehring, Noa Sela, O Ram, P Deininger, PL Deininger, R Cordaux, R Sorek, R Sorek, R Sorek, RA Gibbs, RE Mills, RH Waterston, RM Kuhn, RT Hillman, S He, S Schwartz, SK Ng, SS Singer, ST Sherry, T Kwan, T Kwan, VV Kapitonov, W Makalowski, WJ Kent, WL Chen, WS Lo, XH Zhang, Y Xing, YF Chang   +77 more
core   +4 more sources

Dnmt1 has de novo activity targeted to transposable elements

Nature Structural & Molecular Biology, 2021
DNA methylation plays a critical role during development, particularly in repressing retrotransposons. The mammalian methylation landscape is dependent on the combined activities of the canonical maintenance enzyme Dnmt1 and the de novo Dnmts, 3a and 3b.
Chuck Haggerty, H. Kretzmer, Christina Riemenschneider, Abhishek Sampath Kumar, Alexandra L. Mattei, Nina Bailly, Judith Gottfreund, Pay Giesselmann, Raha Weigert, Björn Brändl, Pascal Giehr, René Buschow, Christina Galonska, Ferdinand von Meyenn, M. Pappalardi, M. McCabe, L. Wittler, C. Giesecke-Thiel, T. Mielke, D. Meierhofer, B. Timmermann, F. Müller, J. Walter, A. Meissner   +23 more
semanticscholar   +1 more source

Recombination drives vertebrate genome contraction. [PDF]

PLoS Genetics, 2012
Selective and/or neutral processes may govern variation in DNA content and, ultimately, genome size. The observation in several organisms of a negative correlation between recombination rate and intron size could be compatible with a neutral model in ...
Kiwoong Nam, Hans Ellegren
doaj   +1 more source

Transposable element insertions have strongly affected human evolution [PDF]

, 2010
Comparison of a full collection of the transposable element (TE) sequences of vertebrates with genome sequences shows that the human genome makes 655 perfect full-length matches.
Britten, Roy J.
core   +2 more sources

Locus-specific expression of transposable elements in single cells with CELLO-seq

Nature Biotechnology, 2021
Transposable elements (TEs) regulate diverse biological processes, from early development to cancer. Expression of young TEs is difficult to measure with next-generation, single-cell sequencing technologies because their highly repetitive nature means ...
Rebecca V Berrens, A. Yang, C. Laumer, A. Lun, Florian Bieberich, Cheuk-Ting Law, Guocheng Lan, M. Imaz, Joseph S. Bowness, N. Brockdorff, Daniel J. Gaffney, J. Marioni   +11 more
semanticscholar   +1 more source

SoyTEdb: a comprehensive database of transposable elements in the soybean genome

BMC Genomics, 2010
Background Transposable elements are the most abundant components of all characterized genomes of higher eukaryotes. It has been documented that these elements not only contribute to the shaping and reshaping of their host genomes, but also play ...
Zhu Liucun, Nelson Rex T, Tian Zhixi, Grant David, Du Jianchang, Shoemaker Randy C, Ma Jianxin   +6 more
doaj   +1 more source

Occurrence of LINE, gypsy-like, and copia-like retrotransposons in the clonally propagated sweet potato (Ipomoea batatas L.) [PDF]

, 2011
Retrotransposons are a class of transposable elements that represent a major fraction of the repetitive DNA of most eukaryotes. Their abundance stems from their expansive replication strategies.
Dieters, Mark, Godwin, Ian, Harding, Rob, Okpul, Tom   +3 more
core   +2 more sources