Results 231 to 240 of about 121,903 (271)
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Retroviral DNA integration: lessons for transposon shuffling
Gene, 1993Phylogenetic comparisons of retroviral IN (integrase) protein sequences have revealed homologies that extend to the retrotransposon and bacterial transposase families and have provided evidence for at least two functional domains. The N-terminal region is characterized by a Zn-finger-like array which is conserved in retrotransposons. The central region
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A Virophage at the Origin of Large DNA Transposons
Science, 2011A parasite of a giant DNA virus that rescues the host has been shown to be the progenitor of a widespread transposon.
Fischer, M., Suttle, C.
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Computational Methods for Identification of DNA Transposons
2013The initial identification of transposable elements (TEs) was attributed to the activity of DNA transposable elements, which are prevalent in plants. Unlike RNA elements, which accumulate in the gene-poor heterochromatic regions, most DNA elements are located in the gene rich regions and many of them carry genes or gene fragments. As such, DNA elements
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DNA Elimination in Ciliates: Transposon Domestication and Genome Surveillance
Annual Review of Genetics, 2011Ciliated protozoa extensively remodel their somatic genomes during nuclear development, fragmenting their chromosomes and removing large numbers of internal eliminated sequences (IESs). The sequences eliminated are unique and repetitive DNAs, including transposons.
Douglas L, Chalker, Meng-Chao, Yao
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Transposons, DNA methylation and gene control
Trends in Genetics, 1998The issues raised by Adrian Bird and Tim Bestor concerning the role of DNA methylation in mammalian genomes1 and 2might usefully be addressed by revisiting some old ideas in plants. Bestor has proposed that DNA methylation is restricted almost entirely to transposable elements, which constitute more than a third of the mouse genome. The primary role of
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Pokey, a New DNA Transposon in Daphnia (Cladocera: Crustacea)
Journal of Molecular Evolution, 2002We report the complete sequence of two representatives of the transposable element, Pokey, isolated from the ribosomal DNA of the cladoceran, Daphnia pulicaria. We describe the general features of this element, which confirms its classification as a DNA transposon. We show that Pokey is similar to piggyBac and, as such, is a member of the TTAA-specific
Erin H, Penton +2 more
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A novel transposon for functional expression of DNA libraries
Journal of Biotechnology, 2006Environmental DNA libraries are important sources for novel biocatalyst genes but activity screening for relevant enzymes is often inefficient. Therefore, we have constructed the transposon MuExpress which randomly integrates in vitro into existing bacterial artificial chromosome (BAC) or cosmid libraries and permits the inducible expression of its ...
Christian, Leggewie +4 more
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DNA Transposons for Modification of Human Primary T Lymphocytes
2009Genetic modification of peripheral blood T lymphocytes (PBL) or hematopoietic stem cells (HSC) has been shown to be promising in the treatment of cancer (Nat Rev Cancer 3:35-45, 2003), transplant complications (Curr Opin Hematol 5:478-482, 1998), viral infections (Science 285:546-551, 1999), and immunodeficiencies (Nat Rev Immunol 2:615-621, 2002 ...
Xin, Huang +3 more
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Molecular Genetics and Genomics, 2004
A family of transposable elements belonging to the hAT group of DNA transposons is described from an oomycete, the plant pathogen Phytophthora infestans. The family, named DodoPi, was identified by studying a hotspot for retro- and DNA transposon insertions adjacent to the mating type locus.
A M V, Ah Fong, H S, Judelson
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A family of transposable elements belonging to the hAT group of DNA transposons is described from an oomycete, the plant pathogen Phytophthora infestans. The family, named DodoPi, was identified by studying a hotspot for retro- and DNA transposon insertions adjacent to the mating type locus.
A M V, Ah Fong, H S, Judelson
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A helix-turn-helix DNA-binding motif predicted for transposases of DNA transposons
Molecular and General Genetics MGG, 1997A helix-turn-helix (HTH) DNA-binding motif is identified in transposase sequences in Tc1, mariner and pogo DNA transposum. The findings are supported by results of various sequence analysis methods. Tc1 transposases are also predicted to contain another DNA-binding region. These findings are in accord with experimental evidence obtained from Tc1A, Tc3A
S, Pietrokovski, S, Henikoff
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