Cell Reports, 2019 Summary: Certain Gram-negative bacteria use the type VI secretion system (T6SS) to kill and lyse competing bacteria. Here, we show that the T6SS-dependent lysis of prey cells by the naturally competent Acinetobacter baylyi results in the extensive ...
Lin Lin +4 more
doaj +1 more source
Lead-induced DNA damage in Vicia faba root cells: Potential involvement of oxidative stress [PDF]
, 2011 Genotoxic effects of lead (0–20 µM) were investigated in whole-plant roots of Vicia faba L., grown hydroponically under controlled conditions. Lead-induced DNA damage in V.
Jean, Séverine +7 more
core +1 more source
Quantitative assessment of the comparative nanoparticle-uptake efficiency of a range of cell lines [PDF]
, 2011 Interest continues to grow in the possibility of understanding the mechanism(s) of nanoparticle-cell interactions. At present there is little knowledge, and essentially no understanding, of the relevant length and time scales for nanoparticle ...
Dawson, Kenneth A +15 more
core +1 more source
OncoImmunology, 2023 DNA vaccines have been an attractive approach for treating cancer patients, however have demonstrated modest immunogenicity in human clinical trials.
Ichwaku Rastogi, Douglas G. McNeel
doaj +1 more source
Delivery of drugs, proteins and genes into cells using transferrin as a ligand for receptor-mediated endocytosis [PDF]
, 1994 Transferrin, an iron-transporting serum glycoprotein, is efficiently taken up into cells by the process of receptor-mediated endocytosis. Transferrin receptors are found on the surface of most proliferating cells, in elevated numbers on erythroblasts and
Matt Cotten +5 more
core +1 more source
Optimising DNA binding to carbon nanotubes by non-covalent methods [PDF]
, 2011 The use of carbon nanotubes as a gene delivery system has been extensively studied in recent years owing to its potential advantages over viral vectors.
Coley, Helen M. +23 more
core +1 more source
Rotaxanes as Cages to Control DNA Binding, Cytotoxicity and Cellular Uptake of a Small Molecule [PDF]
, 2020 In this paper we report a unique approach to control the DNA interactions, cellular uptake and cellular localisation of a small molecule. We have designed rotaxanes that include a luminescent DNA binder, a macrocycle that modulates the DNA binding and a ...
Ramon, Vilar +4 more
core +2 more sources
Tissue-infiltrating macrophages mediate an exosome-based metabolic reprogramming upon DNA damage
Nature Communications, 2020 DNA damage is associated with metabolic disorders, but the mechanism in unclear. Here, the authors show that persistent DNA damage induced by lack of the endonuclease XPF-ERCC1 triggers extracellular vesicle biogenesis in tissue infiltrating macrophages,
Evi Goulielmaki +12 more
doaj +1 more source
Restriction and sequence alterations affect DNA uptake sequence-dependent transformation in Neisseria meningitidis. [PDF]
PLoS ONE, 2012 Transformation is a complex process that involves several interactions from the binding and uptake of naked DNA to homologous recombination. Some actions affect transformation favourably whereas others act to limit it.
Ole Herman Ambur +4 more
doaj +1 more source
Gold nanoparticles explore cells: cellular uptake and their use as intracellular probes [PDF]
, 2014 Understanding uptake of nanomaterials by cells and their use for intracellular sensing is important for studying their interaction and toxicology as well as for obtaining new biological insight.
Septiadi, Dedy +7 more
core +1 more source