Results 11 to 20 of about 8,074 (224)
Mechanochemical Activation of DNAzyme by Ultrasound
Advanced ScienceControlling the activity of DNAzymes by external triggers is an important task. Here a temporal control over DNAzyme activity through a mechanochemical pathway with the help of ultrasound (US) is demonstrated.
Wolfgang H. Rath +2 more
doaj +4 more sources
Dissipatively Fueled Unidirectionally Communicating DNA Circuits That Control Biocatalysis. [PDF]
Angew Chem Int Ed EnglUnidirectionally communicating, out‐of‐equilibrium DNA circuits are used to control enzyme activity. Transient DNAzyme activation generates fuel for temporal trypsin activation. Cyclic fuel‐driven hybridization and exonuclease‐mediated reset enable precise control over lifetimes, which is analyzed using combined experimental and computational ...
Jung P +6 more
europepmc +3 more sources
Nucleic Acids Symposium Series, 2003 Conjugate DNAzymes were synthesized by solid phase fragment condensation and their biological properties were characterized. They have increased affinity to target RNA, enhanced stability against DNase 1 digestion and comparable or higher RNA cleaving activity compared with native and also phosphorothioate DNA zymes.
Takanori, Kubo +4 more
openaire +2 more sources
Analytical Chemistry, 2016 Silver is a very common heavy metal, and its detection is of significant analytical importance. DNAzymes are DNA-based catalysts; they typically recruit divalent and trivalent metal ions for catalysis. Herein, we report a silver-specific RNA-cleaving DNAzyme named Ag10c obtained after six rounds of in vitro selection. Ag10c displays a catalytic rate of
Saran, Runjhun, Liu, Juewen
openaire +3 more sources
DNAzymes and cardiovascular disease [PDF]
British Journal of Pharmacology, 2008 Gene silencing techniques are gaining increasing popularity in the literature, both as a tool for unravelling gene function and to potentially deliver therapeutic benefit, especially in the context of cardiovascular disease. Gene‐specific catalytic DNA molecules, or DNAzymes, have shown promise in ameliorating the effects of myocardial ischaemia ...
V L, Benson, L M, Khachigian, H C, Lowe
openaire +2 more sources
DNAmoreDB, a database of DNAzymes [PDF]
Nucleic Acids Research, 2020 Abstract Deoxyribozymes, DNA enzymes or simply DNAzymes are single-stranded oligo-deoxyribonucleotide molecules that, like proteins and ribozymes, possess the ability to perform catalysis. Although DNAzymes have not yet been found in living organisms, they have been isolated in the laboratory through in vitro selection.
Almudena Ponce-Salvatierra +2 more
openaire +2 more sources
Sensors, 2022 In this work we investigated the effect of a DNA oligonucleotide sequence on the activity of a DNAzyme with covalently attached hemin. For this purpose, we synthesized seven DNA-hemin conjugates.
Joanna Kosman +4 more
doaj +1 more source
Molecular Features and Metal Ions That Influence 10-23 DNAzyme Activity
Molecules, 2020 Deoxyribozymes (DNAzymes) with RNA hydrolysis activity have a tremendous potential as gene suppression agents for therapeutic applications. The most extensively studied representative is the 10-23 DNAzyme consisting of a catalytic loop and two substrate ...
Hannah Rosenbach +5 more
doaj +1 more source
Efficient silencing of gene expression by an ASON-bulge-DNAzyme complex. [PDF]
PLoS ONE, 2011 BACKGROUND: DNAzymes are DNA molecules that can directly cleave cognate mRNA, and have been developed to silence gene expression for research and clinical purposes.
Jianzhong Yi, Chengqian Liu
doaj +1 more source
The impact of Niosomal DNAzyme targeting the NFκB gene on factors involved in cell migration of MCF-7 breast cancer cells [PDF]
مجله پزشکی دانشگاه علوم پزشکی تبریزBackground. As one of the most common human malignancies, breast cancer is the second leading cause of cancer-related death among women globally. Multiple cellular and molecular mechanisms contribute to the development and progression of breast cancer ...
Leila Aghamohseni +2 more
doaj +1 more source