Results 71 to 80 of about 94,936 (269)

De‐Escalation of Neoadjuvant Treatment for HER2‐Positive Breast Cancer

International Journal of Cancer, EarlyView.
ABSTRACT With improved prognosis in early HER2‐positive breast cancer, safely de‐escalating treatment is increasingly investigated to minimize overtreatment. This article focuses on neoadjuvant de‐escalation strategies for HER2‐positive breast cancer.
Yiyin Ma, Dedian Chen, Sheng Huang
wiley   +1 more source

MET Expression in Upper Gastrointestinal Adenocarcinoma: Prevalence, Prognostic Impact, and Implications for Anti‐MET Antibody‐Drug Conjugate Therapy

International Journal of Cancer, EarlyView.
ABSTRACT MET is an actionable receptor tyrosine kinase, and MET‐directed antibody–drug conjugates (ADCs) have recently entered clinical practice with FDA approval in non‐small cell lung cancer and are now being evaluated across gastrointestinal malignancies, with patient selection based on MET immunohistochemistry (IHC) 3+ membranous staining at ...
Tillmann Bedau, Thomas Zander, Hans Anton Schlößer, Hakan Alakus, Onur Mustafov, Reinhard Büttner, Christiane Bruns, Alexander Quaas   +7 more
wiley   +1 more source

ABA enhances the apoptotic effect of docetaxel in the multidrug-resistant DU145 prostate cancer cell line [PDF]

Archives of Biological Sciences
This study aimed to induce drug resistance in DU145 prostate cancer cells by exposing them to docetaxel and mitoxantrone, and to examine the effects of combining docetaxel and abscisic acid (ABA).
Şumnulu Deniz, Doğanlar Zeynep Banu
doaj   +1 more source

Docetaxel cytotoxicity.

, 2016
Cytotoxic effects of docetaxel (DTX), docetaxel + ESWs (DTX ESWs), docetaxel-NBs (DTX NB), and docetaxel-loaded NBs + ESWs (DTX NB ESWs), in PC3 (panel A) and DU145 (panel B) cells.
Paolo Gontero (3534284), Antonino Battaglia (3534293), Roberta Cavalli (559998), Roberto Frairia (3597725), Rossella Peluso (3597722), Letizia Rinella (3597713), Nicoletta Fortunati (3597719), Monica Argenziano (703352), Patrizia D’Amelio (376080), Francesca Sassi (367185), Maria Graziella Catalano (3597716), Ornella Bosco (2559373), Francesca Marano (3597710)   +12 more
core   +1 more source

Global Real‐World Outcomes of Olaparib in Metastatic Castration‐Resistant Prostate Cancer Patients With Homologous Recombination Repair Alterations

International Journal of Cancer, EarlyView.
ABSTRACT Evidence to guide the treatment for patients with metastatic castration‐resistant prostate cancer (mCRPC) and Homologous Recombination Repair (HRR) gene alterations outside of clinical trials remains limited. This was an observational, cohort study, including mCRPC patients with tumor harboring HRR alterations, progressed on a prior androgen ...
Lorena Incorvaia, Daniele Santini, Marc R. Matrana, Marco Maruzzo, Ray Manneh Kopp, Lorenzo Antonuzzo, Sergio Bracarda, Deniz Tural, Giuseppe Procopio, Maria T. Bourlon, Orazio Caffo, Martin Ignacio Zapata Laguado, Massimo Di Maio, Brigida Anna Maiorano, Vincenza Conteduca, Sabrina Rossetti, Helga Lipari, Thomas Büttner, Mimma Rizzo, Yüksel Ürün, Carlo Messina, Fernando Sabino Marques Monteiro, Andrey Soares, Mattia Puglisi, Alice Principi, Eleonora Lai, Giulia Mammone, Marco Stellato, Ilaria Depetris, Tancredi Didier Bazan Russo, Isadora Yasbick Spricido, Camila Bobato Lara Gismondi, Francesco Massari, Nicola Pavan, Matteo Santoni, Tarek Taha   +35 more
wiley   +1 more source

Survival after docetaxel for metastatic castration-resistant prostate cancer in a rural health care setting [PDF]

Introduction: The aim of this study was to evaluate overall survival of men who received systemic therapy with docetaxel for metastatic castration- resistant prostate cancer (MCRPC) in rural Nordland County, Norway.
Nieder, Carsten, Carsten Nieder, Haukland, Ellinor Christin, Ellinor Haukland, Stanisavljevic, Luka, Astrid Dalhaug, Luka Stanisavljevic, Dalhaug, Astrid   +7 more
core   +1 more source

Sex‐Specific Proteomic Profiling Identifies Pregnancy Zone Protein as a Complement‐Linked Marker of Adverse Prognosis in Esophageal Adenocarcinoma

International Journal of Cancer, EarlyView.
ABSTRACT Esophageal adenocarcinoma (EAC) exhibits marked male predominance with male‐to‐female ratios reaching 8.5:1, yet the molecular basis underlying this sex disparity remains poorly characterized. We analyzed 92 EAC specimens using mass spectrometry–based proteomics, comprising 47 female and 45 male tumors from treatment‐naïve patients ...
Alexander Quaas, Hanna Schiemann, Su Ir Lyu, Thomas Zander, Axel Hillmer, Hans Schlößer, Christiane J. Bruns, Reinhard Büttner, Bastian Grothey   +8 more
wiley   +1 more source

EGFR‐mediated hyperacetylation of tubulin induced docetaxel resistance by downregulation of HDAC6 and upregulation of MCAK and PLK1 in prostate cancer cells

Kaohsiung Journal of Medical Sciences
Docetaxel‐based chemotherapy has generally been considered as one of the effective treatments for castration‐resistant prostate cancer (PCa). However, clinical treatment with docetaxel often encounters a number of undesirable effects, including drug ...
Yeong‐Shiau Pu, Chao‐Yuan Huang, Hung‐Lin Wu, Jyun‐Hong Wu, Ying‐Fang Su, Chang‐Tze Ricky Yu, Chi‐Yu Lu, Wen‐Jeng Wu, Shu‐Pin Huang, Ying‐Tang Huang, Tzyh‐Chyuan Hour   +10 more
doaj   +1 more source

How nanotechnology can enhance docetaxel therapy

, 2013
Li Zhang, Na ZhangSchool of Pharmaceutical Science, Shandong University, Shandong Province, People's Republic of ChinaAbstract: Docetaxel has been recognized as one of the most efficient anticancer drugs over the past decade; however, its poor water ...
Zhang N, Zhang L
core  

Assessment of Cancer‐Related Cognitive Impairments Across Anti‐Cancer Therapies in a Predominantly Breast Cancer Cohort

International Journal of Cancer, EarlyView.
ABSTRACT Cancer survivors frequently experience cancer‐related cognitive impairment (CRCI), but the contributions of different anti‐cancer therapies remain unclear. Patients with breast or gynaecological cancer were recruited before any anti‐cancer treatment.
Qiqi Lei, Martina E. Schmidt, Philipp Zimmer, Patric Meyer, Andreas Schneeweiss, Karen Steindorf   +5 more
wiley   +1 more source