Results 61 to 70 of about 98,224 (178)

Weekly docetaxel and gemcitabine following docetaxel plus epirubicin or vinorelbine as first-line treatment of metastatic breast cancer : Results of a multicenter phase ii study

, 2006
AIMS AND BACKGROUND: Sequential docetaxel and gemcitabine following initial docetaxel plus epirubicin or vinorelbine association could be worthwhile as first-line treatment of metastatic breast cancer.
DANOVA M., LUCHENA G., GIORDANO M., PUGLIESE P., BERTE R., TROTTI G., RICCARDI, ALBERTO, BRUGNATELLI S., GRASSO D., TINELLI C., PANSINI G.   +10 more
core   +2 more sources

Mannan-modified Ad5-PTEN treatment combined with docetaxel improves the therapeutic effect in H22 tumor-bearing mice

, 2012
Zhongbing Liu, Jinwei Li, Juan Li, Juan Huang, Famin Ke, Qiaona Qi, Xing Jiang, Zhirong ZhongLuzhou Medical College, Luzhou, Sichuan, People's Republic of ChinaBackground: It has been reported that the tumor suppressor gene, PTEN, which is ...
Liu Z, Li J, Ke F, Huang J, Jiang X, Zhong Z, Qi Q   +6 more
core  

Intratumoral Comparison of Nanoparticle Entrapped Docetaxel (CPC634) with Conventional Docetaxel in Patients with Solid Tumors

, 2020
Purpose: CPC634 is a novel nanoparticle entrapping docetaxel, developed to enhance the intratumoral chemotherapy exposure. This randomized cross-over study compared the intratumoral and plasma pharmacokinetics of CPC634 with conventional docetaxel ...
Moelker, Adriaan, van Hylckama Vlieg, Marte A.M., Rijcken, Cristianne J., Hanssen, Rob, van Eerden, Ruben A.G., Sparreboom, Alex, Hoop, Esther Oomende; id_orcid, Koolen, Stijn L.W., Atrafi, Florence, de Bruijn, Peter, Mathijssen, Ron H.J.; id_orcid, Lolkema, Martijn P., Eskens, Ferry A.L.M.   +12 more
core   +1 more source

Dual inhibition of MEK and PI3Kβ/δ–a potential therapeutic strategy in PTEN-wild-type docetaxel-resistant metastatic prostate cancer

Frontiers in Pharmacology
Background: Docetaxel remains the standard treatment for metastatic castration-resistant prostate cancer (mCRPC). However, resistance frequently emerges as a result of hyperactivation of the PI3K/AKT and the MEK/ERK pathways. Therefore, the inhibition of
Vicenç Ruiz de Porras, Vicenç Ruiz de Porras, Vicenç Ruiz de Porras, Adrià Bernat-Peguera, Adrià Bernat-Peguera, Clara Alcon, Fernando Laguia, Maria Fernández-Saorin, Maria Fernández-Saorin, Natalia Jiménez, Ana Senan-Salinas, Ana Senan-Salinas, Carme Solé-Blanch, Carme Solé-Blanch, Andrea Feu, Mercedes Marín-Aguilera, Juan Carlos Pardo, Juan Carlos Pardo, Juan Carlos Pardo, Maria Ochoa-de-Olza, Maria Ochoa-de-Olza, Maria Ochoa-de-Olza, Joan Montero, Begoña Mellado, Begoña Mellado, Albert Font, Albert Font, Albert Font   +27 more
doaj   +1 more source

Docetaxel neuropathy: a distal axonopathy

, 1999
Docetaxel has been implicated as a causative agent in peripheral neuropathy, but pathological changes in peripheral nerve have not been described. During docetaxel treatment a 54-year-old man developed a sensorimotor polyneuropathy when the overall ...
R. Fazio, A. Bolognesi, A. Quattrini, N. Canal, R. Nemni, S. Previtali, G. Bordogna, E. Villa, Nemni R., Villa E., Bolognesi A., Previtali S., Canal N., Fazio R., Bordogna G., Quattrini A.   +15 more
core   +1 more source

Patient management and docetaxel

, 1997
Potent new drugs such as docetaxel (Taxotere®) will alter our perspective on advanced breast cancer, allowing significant disease responses and symptom palliation in many patients.
Val Aston
core   +1 more source

Peripheral neurotoxicity induced by docetaxel

, 1996
Docetaxel, a new semisynthetic taxoid used as an antineoplastic agent, induced a predominantly sensory neuropathy in 20 of 41 patients. We assessed neurotoxicity in all patients participating in four phase II trials conducted in our institution.
Hilkens, P. H.E., Verweij, J., Stoter, G., Vecht, Ch J., Van Den Bent, M. J.; id_orcid, Van Putten, W. L.J.   +5 more
core   +1 more source

Effects of formulation on pharmacokinetics of docetaxel in rats

, 2020
The aim of this study was to investigate the effects of formulation vehicles on the pharmacokinetics of docetaxel. The following three formulations of docetaxel were prepared to compare the pharmacokinetic profiles of docetaxel: Tween® 80 formulation (a ...
이화정, 이병구
core   +1 more source

Pharmacokinetics and Toxicities of Oral Docetaxel Formulations Co-Administered with Ritonavir in Phase I Trials

Clinical Pharmacology: Advances and Applications, 2021
Marit Vermunt,1 Serena Marchetti,2 Jos Beijnen1,3,4 1Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam 1066, CX, the Netherlands; 2Department of Clinical Pharmacology, The Netherlands Cancer Institute, Amsterdam 1066,
Vermunt M, Marchetti S, Beijnen J
doaj  

Docetaxel-Induced Systemic Sclerosis with Internal Organ Involvement Masquerading as Congestive Heart Failure

Case Reports in Immunology, 2017
Systemic sclerosis, or scleroderma, is a complex medical disorder characterized by limited or diffuse skin thickening with frequent involvement of internal organs such as lungs, gastrointestinal tract, or kidneys.
Bumsoo Park, Raghavendra C. Vemulapalli, Amit Gupta, Maria E. Shreve, Della A. Rees   +4 more
doaj   +1 more source