Results 61 to 70 of about 1,745,904 (301)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Landscape compositions of stone and plants in the heritage of professor L.I. Rubtsov

Інтродукція Рослин, 2012
Doctor of science (biology) L.I. Rubtsov`s theoretical developments and results of activity in creating compositions of stone and plants are represented.
E.L. Rubtsova
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

The Lives of Elderly Residents in Nursing Homes (Panti Jompo): Social Dynamics, Well-Being, and Challenges in Later Life [PDF]

BIO Web of Conferences
This study aims to examine the social dynamics, well-being, and challenges faced by elderly residents living in nursing homes. Using a qualitative approach, it explores the daily experiences of the elderly within the nursing home environment, including ...
Solina Emmy, Wisadirana Darsono, Kuswandoro Wawan Edi, Chawa Anif Fatma, Kanto Sanggar, Rozuli Ahmad Imron, Nurhadi Iwan   +6 more
doaj   +1 more source

The language of risk and the risk of language [PDF]

, 2010
This mini-dissertation is written towards an MA in Linguistics. As such, it falls within the domain of Humanities. However, its author is a doctor and the subject matter is medical, which falls within the domain of Science.
Perrott, Vanessa
core  

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Sir William Osler: facets of personality [PDF]

Терапевтический архив
William Osler is one of the most honored and influential physicians in the English medicine late 19th early 20th century, who has made a great contribution on development of medical science and it’s teaching.
Sergei V. Guliaev, Sergey V. Valentinovich   +1 more
doaj   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Chinese expert consensus on the management of hydraulic-coupled intracranial pressure monitoring via external ventricular drainage

Chinese Journal of Contemporary Neurology and Neurosurgery
Intracranial pressure (ICP) monitoring serves as a critical component in the management of neurocritical care patients. Hydraulic-coupled intracranial pressure monitoring via external ventricular drainage (EVD-ICP) monitoring offers a clinically ...
Chinese Neurosurgical Intensive Care Management Collaborative Group, Minimally Invasive and Non-Invasive Professional Committee of Chinese Research Hospital Association, Neurosurgery Branch of the He'nan Medical Doctor Association, Neurosurgery Professional Committee of He'nan Medical Science Popularization Society   +3 more
doaj   +1 more source

Orations relating to the conferment of Doctor of Science honoris causa to Professor William Bannister [PDF]

, 2014
We are gathered here today to recognise a distinguished international scientist and alumnus of this University and it is indeed my honour and privilege to present Professor William Bannister for the award of the degree of Doctor of Science honoris causa.
LaFerla, Godfrey
core