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Organocatalytic Domino Reactions

Current Organic Chemistry, 2009
Since the rediscovery of proline in 2000 as catalyst in aldol reaction by List, Barbas and Lerner and, soon after, the development of iminium catalysis by D. W. C. MacMillan, the emergence of organocatalysis as an important tool in organic synthesis is outstanding.
Alba, Andrea-Nekane   +3 more
openaire   +3 more sources

Domino Reactions Triggered by Hydroformylation

2013
HF reaction represents a selective method for the synthesis of aldehydes starting from alkenes. Because of versatile aldehydes reactivity, it is possible to perform different domino protocols based on contemporary HF, including Michael's reaction, reductive amination, cyclopropanation, lactonization, and many others. This overview reports on the last 5
Petricci, Elena, Cini, Elena
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Domino Reactions in Drug Design and Discovery

Current Drug Discovery Technologies, 2016
With reference to challenges in developing varied and exceedingly complex scaffolds expeditiously through atom economy, domino reactions have assumed a significant role in several transformative endeavors towards established pharmaceuticals and new chemical entities across diverse therapeutic classes such as HIV integrase inhibitors, DPP4 [dipeptidyl ...
Shanta, Bhar, Mucheli M V, Ramana
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Thermally Induced Cyclobutenone Rearrangements and Domino Reactions

Angewandte Chemie International Edition, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Harrowven, David C.   +2 more
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Divergent Domino Reactions of Sulfur Ylides: Access to Functionalized Six- and Seven-Membered Nitrogen-Heterocycles.

Organic Letters, 2018
Divergent domino annulation reactions of sulfur ylides and azadienes were developed. A wide range of functionalized benzofuran-fused six- and seven-membered nitrogen-heterocyclic compounds were prepared in moderate to excellent yields under mild ...
Jun-Hua Chen, Penghao Jia, Y. Huang
semanticscholar   +1 more source

Substrate-Controlled Domino Reactions of Crotonate-Derived Sulfur Ylides: Synthesis of Benzothiophene Derivatives.

Journal of Organic Chemistry, 2018
Substrate-controlled domino reactions between thioaurones or their analogues and crotonate-derived sulfur ylides were developed and produced a broad spectrum of benzothiophene-fused pyran derivatives, substituted chromene derivatives. In these reactions,
Wenhuan Ding   +4 more
semanticscholar   +1 more source

Synthesis of Polysubstituted 3-Chalcogenated Indoles through Copper(I) Iodide-Catalyzed Three-Component Domino Reactions

Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry, 2018
Polysubstituted 3-chalcogenated indoles were synthesized by a three-component, one-pot, domino reaction of a N-(2-bromophenyl)trifluoroacetamide, a 1-alkyne, a disulfides or diselenides, CuI, and proline in DMF.
Feng Liu, R. Gou, Yi Zhang, Sheng Wu
semanticscholar   +1 more source

New Domino Reactions with Sultones

Synlett, 2009
Hydroxyl-containing α,β-unsaturated δ-sultones undergo a diastereoselective conjugate reduction by Red-Al. This transformation can be extended to a domino elimination/1,4-hydride addition of a tricyclic sultone substrate that is readily available via intramolecular Diels―Alder reaction.
Peter Metz   +5 more
openaire   +1 more source

Microwave-Assisted Domino Cyclization Reactions

Current Microwave Chemistry, 2021
Background: Microwave-assisted domino cyclization reactions have attracted great interest for researchers to synthesize complex compounds in shorter times with increased yields. The domino reactions were used in various synthetic approaches and many drug deliveries in medicinal chemistry with microwave-assisted approaches.
Yogesh B. Wagh, Dipak S. Dalal
openaire   +1 more source

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