Results 11 to 20 of about 28,065 (271)
Frontiers in Neuroscience, 2020 Donepezil is a potent acetylcholinesterase inhibitor, largely used worldwide to alleviate cognitive symptoms in Alzheimer’s disease (AD). Beyond the widely described neuronal impact of donepezil, it was recently shown that targeting connexins, the ...
Benjamin Vidal +9 more
doaj +2 more sources
Vitamin E and Donepezil for the Treatment of Mild Cognitive Impairment [PDF]
New England Journal of Medicine, 2005 BACKGROUND Mild cognitive impairment is a transitional state between the cognitive changes of normal aging and early Alzheimer's disease. METHODS In a double-blind study, we evaluated subjects with the amnestic subtype of mild cognitive impairment ...
Ronald Petersen +13 more
openalex +2 more sources
International Journal of Molecular Sciences, 2021 The acetylcholinesterase inhibitors donepezil and rivastigmine have been used as therapeutic drugs for Alzheimer’s disease (AD), but their effects on LPS- and Aβ-induced neuroinflammatory responses and the underlying molecular pathways have not been ...
Jieun Kim +8 more
semanticscholar +1 more source
Journal of Alzheimer's Disease, 2022 Background: Donepezil is approved for treatment of dementia of the Alzheimer type and is currently available only in tablet forms in the United States.
P. Tariot, R. Braeckman, Charles Oh
semanticscholar +1 more source
Age and Ageing, 2006 An 85-year-old lady with a 4-year history of Alzheimer's dementia was started on a dose of 5 mg of Donepezil. Improvements were noted in her overall mental state with an associated reduction in the level of carer stress but with mild and transient subjective gastrointestinal complaints. Therefore, the dose was cautiously increased to 10 mg.
Ananth Puranik, Chetan Bangra Kuloor
openaire +3 more sources
Donepezil Ameliorates Pulmonary Arterial Hypertension by Inhibiting M2-Macrophage Activation
Frontiers in Cardiovascular Medicine, 2021 Background: The beneficial effects of parasympathetic stimulation in pulmonary arterial hypertension (PAH) have been reported. However, the specific mechanism has not been completely clarified.
Haihua Qiu +6 more
semanticscholar +1 more source
Donepezil for mild cognitive impairment in Parkinson’s disease
Scientific Reports, 2021 We investigated the efficacy of donepezil for mild cognitive impairment in Parkinson’s disease (PD-MCI). This was a prospective, non-randomized, open-label, two-arm study. Eighty PD-MCI patients were assigned to either a treatment or control group.
Kyoungwon Baik +10 more
semanticscholar +1 more source
Pharmaceutics, 2020 Pharmacological treatment of central nervous system (CNS) disorders is difficult, because the blood–brain barrier (BBB) restricts the penetration of many drugs into the brain. To solve this unmet therapeutic need, nanosized drug carriers are the focus of
Gizem Rüya Topal +8 more
semanticscholar +1 more source
Brain and Behavior, 2020 Alzheimer's disease (AD) is a degenerative brain disease that progresses over time, heavily burdening patients, families, and aging societies worldwide. Memantine and donepezil are frequently used in its treatment, both as monotherapy and in combination.
Jiaxun Guo +5 more
semanticscholar +1 more source
Circulation Reports, 2021 Background: Cholinesterase inhibitors such as donepezil are used in the treatment of Alzheimer’s disease. Patients taking cholinesterase inhibitors can develop cholinergically mediated QT prolongation, which may lead to life-threatening arrhythmias.
So Kuwahata +8 more
semanticscholar +1 more source