Results 41 to 50 of about 37,774 (258)

The Impact of Dextran Sodium Sulfate-Induced Gastrointestinal Injury on the Pharmacokinetic Parameters of Donepezil and Its Active Metabolite 6-O-desmethyldonepezil, and Gastric Myoelectric Activity in Experimental Pigs

Molecules, 2021
Gastrointestinal side effects of donepezil, including dyspepsia, nausea, vomiting or diarrhea, occur in 20–30% of patients. The pathogenesis of these dysmotility associated disorders has not been fully clarified yet.
Jan Bures, Ilja Tacheci, Jaroslav Kvetina, Vera Radochova, Lukas Prchal, Darina Kohoutova, Martin Valis, Martin Novak, Rafael Dolezal, Marcela Kopacova, Stanislav Rejchrt, Vit Sestak, Veronika Knoblochova, Eva Peterova, Jana Zdarova Karasova   +14 more
doaj   +1 more source

Conformable Device for Independent Measurements of Mucosal and Vascular Barriers in a Complex In Vitro Intestinal Model

Advanced Science, EarlyView.
Development of more complex in vitro models necessitates the development of improved monitoring approaches. This work demonstrates a novel conformable device capable of measuring the resistance of two cell barriers within a single model independently, a significant advantage over conventional trans‐epithelial/endothelial electrical resistance (TEER ...
Alexandra Elisabeth Wheeler, Sonja Blasche, Rob Bradley, Rachana Acharya, Sophie Oldroyd, David Bulmer, Kiran R. Patil, Róisín Meabh Owens   +7 more
wiley   +1 more source

Bayesian value-of-infomation analysis: an application to a policy model of Alzheimer's disease [PDF]

, 2001
A framework is presented that distinguishes the conceptually separate decisions of which treatment strategy is optimal from the question of whether more information is required to inform this choice in the future.
Araki, S., Claxton, K., Neumann, P.J., Weinstein, M.C.   +3 more
core   +1 more source

Clinical Recommendations for the Use of Donepezil 23 mg in Moderate-to-Severe Alzheimer's Disease in the Asia-Pacific Region

Dementia and Geriatric Cognitive Disorders Extra, 2016
Background: The ‘Asia-Pacific Expert Panel (APEX) for donepezil 23 mg' met in November 2015 to review evidence for the recently approved high dose of donepezil and to provide recommendations to help physicians in Asia make informed clinical decisions ...
Marwan Sabbagh, SeolHeui Han, SangYun Kim, Hae-Ri Na, Jae-Hong Lee, Nagaendran Kandiah, Kammant Phanthumchinda, Chuthamanee Suthisisang, Vorapun Senanarong, Ming-Chyi Pai, Diatri Narilastri, Ajit M. Sowani, Encarnita Ampil, Amitabh Dash   +13 more
doaj   +1 more source

‘Hearts and minds’: association, causation and implication of cognitive impairment in heart failure [PDF]

, 2015
The clinical syndrome of heart failure is one of the leading causes of hospitalisation and mortality in older adults. An association between cognitive impairment and heart failure is well described but our understanding of the relationship between the ...
Cannon, Jane A., McMurray, John J.V., Quinn, Terry J.   +2 more
core   +4 more sources

Određivanje donepezil hidroklorida u humanoj plazmi i ljekovitim oblicima pomoću HPLC s detekcijom fluorescencije [PDF]

, 2011
A sensitive, isocratic reversed-phase high performance liquid chromatographic method involving fluorescence detection was developed for the determination of donepezil hydrochloride in tablets and in human plasma.
B. Sultry, G. Khaledi, G. Shabir, Gamal Mostafa, H. Ermer, H. Pappa, H. Sugimoto, I. Lott, J. Hiten, J. Miller, K. Nakashima, M. Radwan, Mohamed Kassem, Mohammed Abonassif, Mohammed Hefnawy, N. Furukori, P. Jeong, S. Kafkala, V. Meyer, Y. Hsin-Hua   +19 more
core   +2 more sources

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Beneficial effects of pharmacological treatment in post-stroke dynamic aphasia: a behavioural and neuroimaging study [PDF]

, 2018
Introduction : Dynamic Aphasia (DA) is a rare form of language disorder characterized by reduced spontaneous speech with preservation of other language functions.
Beltrán-Corbellini, Álvaro, Berthier-Torres, Marcelo Luis, Davila, Guadalupe, Edelkraut, Lisa-Marie, López-Barroso, Diana, Paredes-Pacheco, José, Reina, Sergio, Roé-Vellvé, Núria, Torres-Prioris, María José   +8 more
core  

Donepezil and related cholinesterase inhibitors as mood and behavioral controlling agents. [PDF]

, 2000
Acetylcholinesterase inhibitors (ChEIs) enhance neuronal transmission by increasing the availability of acetylcholine in muscarinic and nicotinic receptors.
A Grob, BJ Carroll, BJ Steinberg, CH Dyck van, D Kaufer, DE Giles, DJ Safer, DS Geldmacher, DS Janowsky, DS Janowsky, DS Janowsky, DS Janowsky, DW Rowntree, EF Willoughby, JC Morris, JL Cummings, JL Cummings, JM Cooney, JM Cooney, KL Davis, KL Lanctot, LJ Thal, M Rosler, MA Raskind, MA Raskind, MA Raskind, MB Bowers, MF Weiner, MS Mega, MS Mega, N Sitaram, PJ Goodnick, PN Tariot, PS Kishnani, RE Becker, RT Rubin, SC Risch, SP Hoopes, SP Wengel, SS Leong, T Burt, Tal Burt, WJ Burke, YM Greene   +43 more
core   +1 more source

Pharmaceuticals Made with Hydrogen: A Sustainable and Efficient Approach Using Flow Synthesis

Chemistry – A European Journal, EarlyView.
We demonstrate a sustainable strategy for pharmaceutical manufacturing by combining hydrogen, heterogeneous catalysis, and continuous flow synthesis. The development of novel catalysts and their application in a multi‐step synthesis of donepezil enabled a highly productive process with no intermediate purification.
Shū Kobayashi, Haruro Ishitani
wiley   +1 more source