Results 41 to 50 of about 28,065 (271)
Brazilian Journal of Pharmaceutical Sciences, 2020 Alzheimer disease (AD) is characterized by a low level of acetylcholine, beta-amyloid (Aβ) aggregation and oxidative stress. Donepezil is the core medicine used for the treatment of AD. Various structural modifications of donepezil have been carried out.
N. Mohsin, Matloob Ahmad
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Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy
Advanced Therapeutics, EarlyView.This review explores emerging nanoplatform strategies designed to modulate neuroimmune responses for treating central nervous system (CNS) disorders. It examines structural and microenvironmental barriers, advances in multifunctional and targeted nanotechnologies, and highlights clinical progress and translational challenges, offering insights into the
Muhammad Usman Akbar +7 more
wiley +1 more source
Innovative transdermal drug delivery systems: Benefits, challenges, and emerging application
BMEMat, EarlyView.The graphical abstract illustrates the diverse nanostructures employed in transdermal drug delivery systems, highlighting their unique mechanisms to penetrate the intricate layers of skin. It provides a detailed representation of the skin's complex anatomy, emphasizing the challenges posed by its barrier properties.
Syed Waqas Ali Shah +9 more
wiley +1 more source
Formulation Strategies to Improve Nose-to-Brain Delivery of Donepezil
Pharmaceutics, 2019 Donepezil (DPZ) is widely used in the treatment of Alzheimer’s disease in tablet form for oral administration. The pharmacological efficacy of this drug can be enhanced by the use of intranasal administration because this route makes bypassing the blood ...
L. Espinoza +6 more
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Extrapyramidal side effect of donepezil hydrochloride in an elderly patient
Medicine, 2020 Introduction: Alzheimer disease (AD) is a neurodegenerative disease characterized by progressive cognitive dysfunction, which is mainly manifested as memory impairment and a reduced ability to self-care, often accompanied by neuropsychiatric and ...
Hong-chun Li +3 more
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Serotonergic Modulators in Alzheimer's Disease: A Hope in the Hopeless Condition
Chemistry &Biodiversity, EarlyView.ABSTRACT Alzheimer's disease (AD) is the main cause of dementia worldwide. AD is a progressive brain neurodegenerative disease due to genetic and environmental factors that induce a progressive accumulation of intracellular hyperphosphorylated tau protein and extracellular amyloid protein (Aβ).
Najlaa Hamed Almohmadi +7 more
wiley +1 more source
Chemistry–Methods, EarlyView.Etched silicon powder‐supported Pd is developed as a durable and efficient catalyst for continuous flow hydrogenation and reductive alkylation. This study develops a novel heterogeneous palladium catalyst immobilized on etched silicon powder, demonstrating high efficiency and long‐term stability under continuous flow conditions.
Zhenzhong Zhang +4 more
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ACS Chemical Neuroscience, 2019 Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with memory and cognitive impairment. Donepezil is an acetylcholinesterase inhibitor used for the symptomatic treatment of AD.
K. V. Krishna +7 more
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Clinical Pharmacology in Drug Development, EarlyView.Abstract A fixed‐dose combination (FDC) tablet formulation of donepezil/memantine (10/20 mg) was developed to improve medication compliance in patients with Alzheimer's disease (AD). This study compared the pharmacokinetic (PK) characteristics and safety profiles of an FDC formulation (donepezil/memantine [10/20 mg]) and single components (SCs) of ...
Minkyu Choi +7 more
wiley +1 more source