Results 41 to 50 of about 43,876 (313)
Potential implications of practice effects in Alzheimer's disease prevention trials. [PDF]
, 2017 IntroductionPractice effects (PEs) present a potential confound in clinical trials with cognitive outcomes. A single-blind placebo run-in design, with repeated cognitive outcome assessments before randomization to treatment, can minimize effects of ...
Ard, M Colin +5 more
core +1 more source
Journal of Pharmacological Sciences, 2022 Donepezil, an acetylcholinesterase inhibitor, is associated with gastrointestinal symptoms, such as nausea, vomiting, and anorexia, which may affect adherence to continuous therapy.
Kouichi Yamamoto +6 more
doaj
Acta Pharmacologica Sinica, 2020 Vascular dementia (VD) is the second most common dementia disease after Alzheimer’s diseases (AD) in the world. Donepezil is used to treat mild to moderate AD, and it has been shown to treat cognitive impairment and memory deficits caused by VD. However,
Wen-xuan Jian +7 more
semanticscholar +1 more source
Donepezil in the Treatment of Narcolepsy [PDF]
Journal of Clinical Sleep Medicine, 2006 Chronic excessive sleepiness impairs the daily life of patients suffering from narcolepsy. Antidepressants that enhance synaptic levels of noradrenaline and serotonin have been reported as having some therapeutic efficacy. For that reason, acetylcholinesterase inhibitors, which elevate acetylcholine levels, may have a protective function with respect ...
openaire +3 more sources
Bayesian value-of-infomation analysis: an application to a policy model of Alzheimer's disease [PDF]
, 2001 A framework is presented that distinguishes the conceptually separate decisions of which treatment strategy is optimal from the question of whether more information is required to inform this choice in the future.
Araki, S. +3 more
core +1 more source
Increased plasma donepezil concentration improves cognitive function in patients with dementia with Lewy bodies: An exploratory pharmacokinetic/pharmacodynamic analysis in a phase 3 randomized controlled trial [PDF]
, 2016 ObjectiveTo investigate whether increasing plasma donepezil concentration further improves cognitive function and neuropsychiatric symptoms without compromising safety in patients with dementia with Lewy bodies (DLB).MethodsWe analyzed data from a 12 ...
Ikeda, Manabu +5 more
core +1 more source
Cognitive performance of healthy young rats following chronic donepezil administration. [PDF]
, 2008 RATIONALE: Experimental studies have investigated the effects of chronic donepezil treatment on the behavioral deficits elicited by reduced activity or the loss of cholinergic neurons that occurs in aging or in models of dementia. However, few studies
Bartolo, P. DE +6 more
core +1 more source
Molecular Medicine, 2023 Background Trastuzumab (Trz)-induced cardiotoxicity (TIC) is one of the most common adverse effects of targeted anticancer agents. Although oxidative stress, inflammation, mitochondrial dysfunction, apoptosis, and ferroptosis have been identified as ...
Thawatchai Khuanjing +8 more
doaj +1 more source
Journal of the Formosan Medical Association, 2022 Background/purpose: Donepezil was approved for the treatment of Alzheimer's disease (AD) but causes variable therapeutic responses. Thus, identifying specific genetic polymorphisms, which can predict a therapeutic response to donepezil, would enable a ...
Ping-Song Chou +4 more
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