Results 101 to 110 of about 2,880,162 (249)
Donor selection, donor management and donor offer procedures [PDF]
One of the major limitations in LTx is represented by the limited donor organ pool. Currently, the acceptance rate of donor lungs is 20–50% worldwide, representing the lowest among all solid organs.
Benazzo, Alberto, Gan, Tji; id_orcid
core +1 more source
Health Science ReportsBackground and Aims Haploidentical hematopoietic stem cell transplantation (haplo‐HSCT) provides curative therapy for patients lacking HLA‐matched donors, yet optimal donor characteristics remain uncertain.
Mahtab Mashayekhi +11 more
doaj +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
, 2017 This chapter provides an historical perspective of living donor nephrectomy from the early days to current applications. The selection criteria for living donors, the various types of surgical approaches available, with particular reference to the ...
Pugliese, Luigi +9 more
core +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
An evaluation of the prevalence and causes of blood donor deferral in Lagos state, Nigeria
Discover Public HealthBackground Blood transfusion safety relies on thorough donor eligibility assessments that lead to the deferral of individuals who do not meet established criteria.
Olufemi Abiola Oyedeji +5 more
doaj +1 more source
Journal of Cardiovascular Development and DiseaseThe current understanding of the safety of heart transplantation from COVID-19+ donors is uncertain. Preliminary studies suggest that heart transplants from these donors may be feasible.
Stanley B. Wolfe +8 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source