Results 111 to 120 of about 2,880,162 (249)

Organ and tissue donation: exploring the needs of families

, 2003
Relatives of potential organ donors are the most critical link in maintaining organ availability, as they must express their lack of objection before organ retrieval may take place. The often sudden and unexpected nature of the death of a potential organ
Long-Sutehall, Tracy, Sque, Magi, Payne, Sheila   +2 more
core   +1 more source

Outcomes of Kidney Transplantation from Deceased Donors with Severe Acute Kidney Injury (AKIN Stage 3): A Preliminary Single-Centre Analysis

Medical Sciences
Background: The shortage of donor kidneys has prompted interest in using organs from donors with severe acute kidney injury (AKI), but robust data on outcomes from donors with AKIN stage 3 remain limited. Methods: This single-centre, retrospective cohort
Juan A. Encarnación, Elisabeth Coll, Clara Manso, Santiago Llorente, Francisco Morales, Isabel Saura, Pedro López-Cubillana, Pablo Luis Guzman Martínez-Valls, Gloria Martínez, Isabel De la Fuente, Enrique Cárdenas, Jose L. Alonso-Romero, Paula Ruiz, José Moya, Beatriz Domínguez-Gil, Mario Royo-Villanova   +15 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

The evaluation of blood donor deferrals at Police General Hospital

Journal of Associated Medical Sciences, 2010
Background : Blood donor selection contributes to the safety of both donors and the recipients. The objective of this study was to identify the number and causes of blood donor deferrals. Also the growing trend of the causes of deferrals was studied. The
Surachai Jantavaree
doaj  

Identification of embryonic yield-related serum biomarkers using proteomic analysis in ovine superovulation

Frontiers in Veterinary Science
Superovulation is an efficient technology for the propagation of excellent livestock. Blood proteins other than reproductive hormones might be related to the outcome of superovulation.
Xiaohu Su, Yijing Zhu, Zirong Guo, Shuang Qiu, Quan Liu, Chao Bian, Liqiang Chen, Hideaki Yamashiro, Guangnan Liu, Zhanwen Zhang, Liguo Zhang, Bin Tong   +11 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Can donor coordination solve the aid proliferation problem ? [PDF]

The paper augments Holmstrom’s (1982) team production model in the context of aid effectiveness. The analysis shows how donor proliferation leads to inefficient supply of aid in the recipient country because of the free-riding problem faced by the donors.
Sawada, Yasuyuki, Rahman, Aminur
core  

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source