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DOPA Metabolism in Neuroblastoma
Medical and Pediatric Oncology, 1980AbstractBlood plasma samples from 60 neuroblastoma patients prior to, during, and following treatment were studied for their content of circulating DOPA using a radioenzymatic assay. Normal values were established from children who were tumor‐free or had other nonneurogenic tumors. The highest plasma DOPA concentration in tumor‐free or nonneuroblastoma
L, Helson, G A, Johnson, R, Smith
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Characterization of dopa decarboxylase
Life Sciences, 1973Publisher Summary This chapter discusses characteristics of DOPA decarboxylase. DOPA decarboxylase, which catalyses the conversion of L-dopa to dopamine, was the first of the catecholamine biosynthetic enzymes to be discovered. In a study, the dopa decarboxylase of hog kidney was purified to homogeneity.
WALLACE DAIRMAN +2 more
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Accurate assay of dopa decarboxylase by preventing nonenzymatic decarboxylation of dopa
Analytical Biochemistry, 1983The nonenzymatic decarboxylation of dopa was completely blocked by both 2-mercaptoethanol and EDTA together over the wide range of pH. This finding made it possible to measure the activity of dopa decarboxylase precisely even at an alkaline pH value. The pH optimum of dopa decarboxylase was found to be pH 7.0 and the Km value for dopa was determined to
S, Okuno, H, Fujisawa
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Current Opinion in Neurology, 1995
The past 18 months have seen significant advances in our understanding of dopa(dihydroxyphenylalanine)-responsive dystonia. Clinical investigations have broadened the spectrum of disease with particular attention manifestations in infancy. Pathophysiological investigations have revealed features that distinguish dopa-responsive dystonia from childhood ...
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The past 18 months have seen significant advances in our understanding of dopa(dihydroxyphenylalanine)-responsive dystonia. Clinical investigations have broadened the spectrum of disease with particular attention manifestations in infancy. Pathophysiological investigations have revealed features that distinguish dopa-responsive dystonia from childhood ...
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2011
Clinical characteristics and pahophysiologies of dopa-responsive dystonia are discussed by reviewing autosomal-dominant GTP cyclohydrolase-I deficiency (AD GCHI D), recessive deficiencies of enzymes of pteridine metabolism, and recessive tyrosine hydroxylase (TH).
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Clinical characteristics and pahophysiologies of dopa-responsive dystonia are discussed by reviewing autosomal-dominant GTP cyclohydrolase-I deficiency (AD GCHI D), recessive deficiencies of enzymes of pteridine metabolism, and recessive tyrosine hydroxylase (TH).
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Archives of Dermatology, 1972
To the Editor.— We are grateful to Dr. Okun for his detailed consideration of dopa and tyrosine oxidases. In our study of lichen planus we observed a striking reduction of dopa-positive melanocytes in the basal region of the epidermis where the lichen planus was active. In the dermal infiltrate we observed a few weekly dopa-positive cells, but we were
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To the Editor.— We are grateful to Dr. Okun for his detailed consideration of dopa and tyrosine oxidases. In our study of lichen planus we observed a striking reduction of dopa-positive melanocytes in the basal region of the epidermis where the lichen planus was active. In the dermal infiltrate we observed a few weekly dopa-positive cells, but we were
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2019
Considering intrinsic limits of 18F-FDG PET/CT in brain and neuroendocrine tumors imaging, several radiopharmaceuticals have been developed to investigate these diseases. Among others, a promising tracer is 18F-DOPA, due to its very low rate of physiological distribution in normal brain structures of white and gray matter and the affinity for somatic ...
Ferdinando Calabria, Orazio Schillaci
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Considering intrinsic limits of 18F-FDG PET/CT in brain and neuroendocrine tumors imaging, several radiopharmaceuticals have been developed to investigate these diseases. Among others, a promising tracer is 18F-DOPA, due to its very low rate of physiological distribution in normal brain structures of white and gray matter and the affinity for somatic ...
Ferdinando Calabria, Orazio Schillaci
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