Results 271 to 280 of about 101,529 (354)

Behavioral Phenotyping of the Pahenu2 Mouse Model for Phenylketonuria—A Scoping Review and Future Perspectives

Journal of Inherited Metabolic Disease, Volume 49, Issue 5, September 2026.
ABSTRACT Phenylketonuria (PKU) is a rare metabolic disorder resulting from a mutation in the gene encoding the enzyme phenylalanine hydroxylase (PAH), resulting in very high phenylalanine (Phe) levels in blood and brain. A PKU mutant mouse model was developed via N‐ethyl‐N‐nitrosourea (ENU) mutagenesis, mimicking the high brain Phe content seen in ...
Junfei Cao, Lennart Kruizinga, Iris B. Hovens, Els van der Goot, Robbert Havekes, Eddy A. van der Zee   +5 more
wiley   +1 more source

M5 positive allosteric modulation alleviates parkinsonian motor deficits. [PDF]

PLoS One
Chambers NE, Hall D, Kaplan M, Garan S, Eichner T, Moehle MS.   +5 more
europepmc   +1 more source

Cell Death in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 9, September 2026.
Regulated cell death pathways, including apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy‐dependent cell death, interact with mitochondrial dysfunction, proteostasis failure, lysosomal stress, glial remodeling, and neuroinflammation across major neurodegenerative diseases.
Tianjiao Li, Qian Zhang, Yichen Wu, Ruixue Huang   +3 more
wiley   +1 more source

No New Relevant Treatment Options for L-DOPA-Induced Dyskinesia from a Clinician's Point of View. [PDF]

Neurol Int
Müller T.
europepmc   +1 more source

Evidence that tyrosine hydroxylase does not have enzymatic activity in neurons of the supraoptic nucleus. [PDF]

Front Endocrinol (Lausanne)
Pronina TS, Troshev DV, Kolacheva AA, Bogdanov VV, Ugrumov MV.   +4 more
europepmc   +1 more source

No Significant Secondary Structural Change of α-Synuclein Monomer by Site-Specific DOPA or Phosphorylation Introduction in Its C-Terminal Region. [PDF]

J Pept Sci
Matsuo T, Suetake I, Kimura M, Hashimoto S, Matsuo K, Matsumoto S, Hirotsune S, Hojo H.   +7 more
europepmc   +1 more source

Early diabetes-like phenotypes in germ-free mice induced by gut microbiota from patients with type 2 diabetes. [PDF]

Animal Model Exp Med
Feng J, Liu X, Zhu H, Yang Y, Liu W, Jiang X, Yang Z.   +6 more
europepmc   +1 more source

Spatial Tail Design in Ionizable Lipids Enhances the Safety and Efficacy of mRNA Delivery. [PDF]

Small Methods
Li H, Tian C, Kong W, Weiss J, Gang J, Zhong T, Ma Y, Xu J, Tai W, Zeng F, Wu S.   +10 more
europepmc   +1 more source

FROM DISCOVERY SCIENCE TO THE CLINIC - HERITABLE ENDOCRINE CANCERS AND RELATED DISORDERS: Functional imaging in hereditary endocrine neoplasms: evolving modalities and clinical implications. [PDF]

Endocr Relat Cancer
Ludgate S, Brennan SC, McNeil J, Tsang VH, Robinson BG, Tacon L, Clifton-Bligh RJ, Gild ML.   +7 more
europepmc   +1 more source

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Dopa-sensitive and Dopa-resistant gait parameters in Parkinson's disease

Journal of the Neurological Sciences, 1991
Quantitative analysis of gait was performed in 20 parkinsonians before and 1 h after the acute administration of L-Dopa in order to discriminate between the Dopa-sensitive and the Dopa-resistant kinematic gait parameters. The stride length and the kinematic parameters (swing velocity, peak velocity) related to the energy were Dopa-sensitive.
G Serratrice
exaly   +3 more sources