Results 31 to 40 of about 259,710 (99)

Multimodal detection of dopamine by sniffer cells expressing genetically encoded fluorescent sensors

Communications Biology, 2022
Dopamine sensor cell lines expressing fluorescent reporters are developed. This versatile tool can record endogenous dopamine release from cultured neurons and striatal slices, determine dopamine tissue content, and detect dopamine uptake and efflux.
Carmen Klein Herenbrink, Jonatan Fullerton Støier, William Dalseg Reith, Abeer Dagra, Miguel Alejandro Cuadrado Gregorek, Reto B. Cola, Tommaso Patriarchi, Yulong Li, Lin Tian, Ulrik Gether, Freja Herborg   +10 more
doaj   +1 more source

Midbrain dopamine neurons signal aversion in a reward-context-dependent manner

eLife, 2016
Dopamine is thought to regulate learning from appetitive and aversive events. Here we examined how optogenetically-identified dopamine neurons in the lateral ventral tegmental area of mice respond to aversive events in different conditions. In low reward
Hideyuki Matsumoto, Ju Tian, Naoshige Uchida, Mitsuko Watabe-Uchida   +3 more
doaj   +1 more source

A role for accumbal glycine receptors in modulation of dopamine release by the glycine transporter-1 inhibitor Org25935

Frontiers in Psychiatry, 2011
Accumbal glycine modulates basal and ethanol-induced dopamine levels in the nucleus accumbens (nAc) as well as voluntary ethanol consumption. Also, systemic administration of the glycine transporter-1 inhibitor Org25935 elevates dopamine levels in nAc ...
Helga eHöifödt Lidö, Mia eEricson, Hugh eMarston, Bo eSöderpalm, Bo eSöderpalm   +4 more
doaj   +1 more source

Dopamine and Dopamine Receptors in Alzheimer's Disease: A Systematic Review and Network Meta-Analysis

Frontiers in Aging Neuroscience, 2019
Background: The dopaminergic system has been associated with the progression of Alzheimer's disease. But previous studies found inconsistent results regarding the relationship between Alzheimer's disease and dopamine when looking at dopamine receptor ...
Xiongfeng Pan, Atipatsa C. Kaminga, Atipatsa C. Kaminga, Shi Wu Wen, Shi Wu Wen, Xinyin Wu, Xinyin Wu, Kwabena Acheampong, Kwabena Acheampong, Aizhong Liu   +9 more
doaj   +1 more source

Dopamine Receptor Gene Expression Changes in Peripheral Blood Mononuclear Cells from Schizophrenic Patients Treated with Haloperidol and Olanzapine

European Journal of Inflammation, 2009
We investigated dopamine receptor gene expression in peripheral blood mononuclear cells of schizophrenic patients before and after treatment. Also dopamine receptor genes expression profile was compared in two treatment groups including haloperidol and ...
G.H. Shariati, G. Ahangari MT, Ph.D., M.R. Asadi, F. Poyafard, H.R. Ahmadkhaniha   +4 more
doaj   +1 more source

Dopamine Has a Critical Role in Photoreceptor Degeneration in the rd Mouse

Neurobiology of Disease, 2002
Photoreceptors receive paracrine input from dopaminergic interplexiform cells. Rod photoreceptors in the rd mouse degenerate rapidly due to a specific gene defect.
Judith Mosinger Ogilvie, Judith D. Speck
doaj   +1 more source

Dopamine-driven increase in IL-1β in myeloid cells is mediated by differential dopamine receptor expression and exacerbated by HIV

Journal of Neuroinflammation
The catecholamine neurotransmitter dopamine is classically known for regulation of central nervous system (CNS) functions such as reward, movement, and cognition. Increasing evidence also indicates that dopamine regulates critical functions in peripheral
Stephanie M. Matt, Rachel Nolan, Samyuktha Manikandan, Yash Agarwal, Breana Channer, Oluwatofunmi Oteju, Marzieh Daniali, Joanna A. Canagarajah, Teresa LuPone, Krisna Mompho, Kaitlyn Runner, Emily Nickoloff-Bybel, Benjamin Li, Meng Niu, Johannes C. M. Schlachetzki, Howard S. Fox, Peter J. Gaskill   +16 more
doaj   +1 more source

A New Negative Charged Self-Assembled Monolayer for Selective Electroanalytical Determination of Dopamine in the Presence of Ascorbic Acid

International Journal of Electrochemical Science, 2011
Voltammetric behavior of dopamine and ascorbic acid on a gold electrode modified with the self-assembled monolayer of 2-mercaptoethanesulfunate has been investigated. This negatively charged layer could act as a discriminating layer against ascorbic acid
Alireza Mohadesi, Mohammad Ali Karimi, Maryam Pourfarsi   +2 more
doaj   +1 more source

Mesolimbic dopamine ramps reflect environmental timescales

eLife
Mesolimbic dopamine activity occasionally exhibits ramping dynamics, reigniting debate on theories of dopamine signaling. This debate is ongoing partly because the experimental conditions under which dopamine ramps emerge remain poorly understood.
Joseph R Floeder, Huijeong Jeong, Ali Mohebi, Vijay Mohan K Namboodiri   +3 more
doaj   +1 more source

Optogenetic stimulation of VTA dopamine neurons reveals that tonic but not phasic patterns of dopamine transmission reduce ethanol self-administration

Frontiers in Behavioral Neuroscience, 2013
There is compelling evidence that acute ethanol exposure stimulates ventral tegmental area (VTA) dopamine cell activity and that VTA-dependent dopamine release in terminal fields within the nucleus accumbens plays an integral role in the regulation of ...
Caroline E Bass, Valentina P Grinevich, Dominic eGioia, Jon eDay-Brown, Keith D Bonin, Garret D Stuber, Jeff L Weiner, Evgeny eBudygin   +7 more
doaj   +1 more source