Dissociable dopamine dynamics for learning and motivation.
Nature, 2019 The dopamine projection from ventral tegmental area (VTA) to nucleus accumbens (NAc) is critical for motivation to work for rewards and reward-driven learning. How dopamine supports both functions is unclear.
Ali Mohebi +8 more
semanticscholar +1 more source
Could dopamine agonists aid in drug development for anorexia nervosa? [PDF]
, 2014 Anorexia nervosa is a severe psychiatric disorder most commonly starting during the teenage-years and associated with food refusal and low body weight. Typically there is a loss of menses, intense fear of gaining weight, and an often delusional quality ...
Frank, Guido KW
core +2 more sources
Performance of dopamine modified 0.5(Ba0.7Ca0.3)TiO3-0.5Ba(Zr0.2Ti0.8)O3 filler in PVDF nanocomposite as flexible energy storage and harvester [PDF]
Journal of Alloys and Compounds,Volume 876, 25 September 2021,
160141, 2021 We demonstrate the potential of dopamine modified 0.5(Ba0.7Ca0.3)TiO3-0.5Ba(Zr0.2Ti0.8)O3 filler incorporated poly-vinylidene fluoride (PVDF) composite prepared by solution cast method as both flexible energy storage and harvesting devices. The introduction of dopamine in filler surface functionalization acts as bridging elements between filler and ...
arxiv +1 more source
Specialized coding of sensory, motor, and cognitive variables in VTA dopamine neurons
Nature, 2019 There is increased appreciation that dopamine neurons in the midbrain respond not only to reward1 and reward-predicting cues1,2, but also to other variables such as the distance to reward3, movements4–9 and behavioural choices10,11. An important question
B. Engelhard +10 more
semanticscholar +1 more source
The dopamine hypothesis of schizophrenia: version III--the final common pathway.
Schizophrenia bulletin, 2009 The dopamine hypothesis of schizophrenia has been one of the most enduring ideas in psychiatry. Initially, the emphasis was on a role of hyperdopaminergia in the etiology of schizophrenia (version I), but it was subsequently reconceptualized to specify ...
O. Howes, S. Kapur
semanticscholar +1 more source
Midbrain Dopamine Neurons Signal Belief in Choice Accuracy during a Perceptual Decision [PDF]
, 2017 Central to the organization of behavior is the ability to predict the values of outcomes to guide choices. The accuracy of such predictions is honed by a teaching signal that indicates how incorrect a prediction was (“reward prediction error,” RPE).
Kepec, A. +4 more
core +2 more sources
Genetic inhibition of neurotransmission reveals role of glutamatergic input to dopamine neurons in high-effort behavior [PDF]
, 2018 Midbrain dopamine neurons are crucial for many behavioral and cognitive functions. As the major excitatory input, glutamatergic afferents are important for control of the activity and plasticity of dopamine neurons.
AA Grace +83 more
core +1 more source
Cell-intrinsic effects of TorsinA(ΔE) disrupt dopamine release in a mouse model of TOR1A dystonia
Neurobiology of Disease, 2021 TOR1A-associated dystonia, otherwise known as DYT1 dystonia, is an inherited dystonia caused by a three base-pair deletion in the TOR1A gene (TOR1AΔE).
Anthony M. Downs +5 more
doaj
Testosterone induces molecular changes in dopamine signaling pathway molecules in the adolescent male rat nigrostriatal pathway. [PDF]
PLoS ONE, 2014 Adolescent males have an increased risk of developing schizophrenia, implicating testosterone in the precipitation of dopamine-related psychopathology.
Tertia D Purves-Tyson +5 more
doaj +1 more source
Representation learning with reward prediction errors [PDF]
arXiv, 2021 The Reward Prediction Error hypothesis proposes that phasic activity in the midbrain dopaminergic system reflects prediction errors needed for learning in reinforcement learning. Besides the well-documented association between dopamine and reward processing, dopamine is implicated in a variety of functions without a clear relationship to reward ...
arxiv