Results 61 to 70 of about 589,499 (392)
Levo-Tetrahydropalmatine Attenuates Cocaine Self-Administration under a Progressive-Ratio Schedule and Cocaine Discrimination in Rats [PDF]
, 2010 Levo-tetrahydropalmatine (l-THP) is an alkaloid found in many traditional Chinese herbal preparations and has a unique pharmacological profile that includes dopamine receptor antagonism.
Baker, David A. +8 more
core +2 more sources
Dopamine-Agonist Induced Cerebrospinal Fluid Rhinorrhea; a Case Report
Journal of Cancer and Allied Specialties, 2021 Introduction: Prolactinomas are the most common pituitary adenomas. Medical therapy with dopamine agonists (DA) is the mainstay of treatment and rarely requires surgical manipulation.
Hira Irfan +5 more
doaj +1 more source
The effect of neuronal conditional knock-out of peroxisome proliferator-activated receptors in the MPTP mouse model of Parkinson's disease [PDF]
, 2015 This study was supported by Parkinson’s Disease Foundation (IRGP 09-11 (P.T.)), the Royal Society (2006/R1 (P.T.)), the Wellcome Trust (WT080782MF (P.T.)), the Biotechnology and Biological Sciences Research Council (P.T.
Evans, R. M. +4 more
core +1 more source
Exploring the underlying mechanisms of drug-induced impulse control disorders: a pharmacovigilance-pharmacodynamic study [PDF]
, 2023 Introduction: Impulse control disorders (e.g. pathological gambling, hypersexuality) may develop as adverse reactions to drugs. Pathogenetic hypotheses have mainly focused on D3-receptor agonism, and switching to alternatives with different pharmacologic
Battini V. +13 more
core +1 more source
Journal of Clinical Endocrinology and Metabolism, 2014 CONTEXT Concern exists in the literature that the long-term use of ergot-derived dopamine agonist drugs for the treatment of hyperprolactinemia may be associated with clinically significant valvular heart disease.
W. Drake +5 more
semanticscholar +1 more source
Functioning of the dimeric GABA(B) receptor extracellular domain revealed by glycan wedge scanning [PDF]
The EMBO Journal 27, 9 (2008) 1321-1332, 2008 The G-protein-coupled receptor (GPCR) activated by the neurotransmitter GABA is made up of two subunits, GABA(B1) and GABA(B2). GABA(B1) binds agonists, whereas GABA(B2) is required for trafficking GABA(B1) to the cell surface, increasing agonist affinity to GABA(B1), and activating associated G proteins.
arxiv +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2015 Significance G protein-coupled receptors (GPCRs) constitute the largest plasma membrane protein family involved in cell signaling. GPCR homodimers are predominant species, and GPCR heteromers likely are constituted by heteromers of homodimers.
J. Bonaventura +14 more
semanticscholar +1 more source
The History and Pharmacology of Dopamine Agonists [PDF]
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1984 ABSTRACTThe recognition of the dopaminergic properties of some ergot derivatives has initiated new therapeutical approaches in endocrinology as well as in neurology. The pharmacological characterization of the different ergot derivatives during the last decade has largely improved our understanding of central dopaminergic systems. Their development has
openaire +4 more sources
Dopamine agonists for restless legs syndrome
Advances in Clinical Neuroscience & RehabilitationRestless Legs Syndrome (RLS) is a common neurological disorder characterised by an uncontrollable urge to move the legs. Dopamine agonists are widely used as first or second-line treatments for RLS due to their efficiency in alleviating the symptoms of ...
Pran Phakdeekitcharoen, Michael J Keogh
doaj +1 more source
Action-modulated midbrain dopamine activity arises from distributed control policies [PDF]
arXiv, 2022 Animal behavior is driven by multiple brain regions working in parallel with distinct control policies. We present a biologically plausible model of off-policy reinforcement learning in the basal ganglia, which enables learning in such an architecture.
arxiv