Results 41 to 50 of about 112,056 (332)

Amphetamine induces dopamine efflux through a dopamine transporter channel [PDF]

Proceedings of the National Academy of Sciences, 2005
Drugs of abuse, including cocaine, amphetamine (AMPH), and heroin, elevate extracellular dopamine (DA) levels in the brain, thereby altering the activity/plasticity of reward circuits and precipitating addiction. The physiological release of DA occurs through the calcium-dependent fusion of a synaptic vesicle with the plasma membrane ...
Kristopher M, Kahlig, Francesca, Binda, Habibeh, Khoshbouei, Randy D, Blakely, Douglas G, McMahon, Jonathan A, Javitch, Aurelio, Galli   +6 more
openaire   +2 more sources

Substrate-induced conformational dynamics of the dopamine transporter

Nature Communications, 2019
The dopamine transporter is responsible for termination of neurotransmission through Na+-driven reuptake of neurotransmitter from the extracellular space. Here authors use hydrogen-deuterium exchange mass spectrometry to monitor Na+- and dopamine-induced
Anne Kathrine Nielsen, Ingvar R. Möller, Yong Wang, Søren G. F. Rasmussen, Kresten Lindorff-Larsen, Kasper D. Rand, Claus J. Loland   +6 more
doaj   +1 more source

Drosophila modifier screens to identify novel neuropsychiatric drugs including aminergic agents for the possible treatment of Parkinson's disease and depression. [PDF]

, 2014
Small molecules that increase the presynaptic function of aminergic cells may provide neuroprotection in Parkinson's disease (PD) as well as treatments for attention deficit hyperactivity disorder (ADHD) and depression.
Biedermann, T, Chou, M-T, Djapri, C, Hadi, R, Huang, B, Jang, J, Krantz, DE, Lam, HA, Lawal, HO, Lawless, GM, Maidment, NT, Roberts, L, Shahi, V, Terrell, A   +13 more
core   +2 more sources

Dopamine Transport in Human Blood

Clinical Chemistry, 1970
Abstract Distribution coefficients were determined for dopamine equilibrated between human blood cells and plasma or its constituents by direct fluorescent reading of this fluorophore recovered in the aqueous phase of a trichloroacetic acid separation. The fluorescence was activated at 280 nm and read at 320nm. Recovery of dopamine added
G, Bryson, F, Bischoff
openaire   +2 more sources

A novel heterocyclic compound CE-104 enhances spatial working memory in the radial arm maze in rats and modulates the dopaminergic system

Frontiers in Behavioral Neuroscience, 2016
Various psychostimulants targeting monoamine neurotransmitter transporters (MAT) have been shown to rescue cognition in patients with neurological disorders and improve cognitive abilities in healthy subjects at low doses.
Yogesh D Aher, Saraswathi eSubramaniyan, Bharanidharan eShanmugasundaram, Ajinkya eSase, Sivaprakasam R Saroja, Marion eHoly, Harald eHoeger, Tetyana eBeryozkina, Harald H Sitte, Johann Jakob Leban, Gert eLubec   +10 more
doaj   +1 more source

Mitogen-Activated Protein Kinase Regulates Dopamine Transporter Surface Expression and Dopamine Transport Capacity [PDF]

The Journal of Neuroscience, 2003
The dopamine transporter (DAT) regulates the clearance of dopamine (DA) released into the extracellular space and is an important site on which psychostimulants act to produce their effects. Here, we show that mitogen-activated protein kinase (MAPK) regulates the transport capacity and intracellular trafficking of DAT.
José A, Morón, Irina, Zakharova, Jasmine V, Ferrer, Gerald A, Merrill, Bruce, Hope, Eileen M, Lafer, Zhi Cheng, Lin, Jia Bei, Wang, Jonathan A, Javitch, Aurelio, Galli, Toni S, Shippenberg   +10 more
openaire   +2 more sources

A study of the dopamine transporter using the TRACT assay, a novel in vitro tool for solute carrier drug discovery

Scientific Reports, 2021
Members of the solute carrier (SLC) transporter protein family are increasingly recognized as therapeutic drug targets. The majority of drug screening assays for SLCs are based on the uptake of radiolabeled or fluorescent substrates.
Hubert J. Sijben, Julie J. E. van den Berg, Jeremy D. Broekhuis, Adriaan P. IJzerman, Laura H. Heitman   +4 more
doaj   +1 more source

Organic Cation Transporter 3 (OCT3) Is Localized to Intracellular and Surface Membranes in Select Glial and Neuronal Cells Within the Basolateral Amygdaloid Complex of Both Rats and Mice [PDF]

, 2016
Organic cation transporter 3 (OCT3) is a high-capacity, low-affinity transporter that mediates corticosterone-sensitive uptake of monoamines including norepinephrine, epinephrine, dopamine, histamine and serotonin. OCT3 is expressed widely throughout the
Chan, June, Gasser, Paul J, Hurley, Matthew M., Pickel, Virginia M.   +3 more
core   +2 more sources

Striatal Dopamine Transporter Availability Associated with Polymorphisms in the Dopamine Transporter Gene SLC6A3 [PDF]

Journal of Nuclear Medicine, 2008
Polymorphisms in the dopamine transporter (DAT) gene SLC6A3 are associated with human striatal DAT expression, but the exact effects on DAT expression are not clear. A variable number of tandem repeats (VNTR) in the 3' untranslated region of the DAT gene was previously investigated in relation to striatal DAT availability, but the results were ...
van de Giessen, Elisabeth M., de Win, Maartje M. L., Tanck, Michael W. T., van den Brink, Wim, Baas, Frank, Booij, Jan   +5 more
openaire   +2 more sources

Corticosterone Regulates Both Naturally Occurring and Cocaine‐Induced Dopamine Signaling by Selectively Decreasing Dopamine Uptake [PDF]

, 2017
Stressful and aversive events promote maladaptive reward‐seeking behaviors such as drug addiction by acting, in part, on the mesolimbic dopamine system. Using animal models, data from our laboratory and others show that stress and cocaine can interact to
Baker, David A., Bohn, Austin T., Ebben, Amanda L., Gasser, Paul J., Jasek, Isabella A., Kurtoglu, Beliz, Lovell, Marissa E., Mantsch, John R., Wheeler, Daniel S., Wheeler, Robert A.   +9 more
core   +2 more sources