Results 121 to 130 of about 116,827 (301)

Imaging striatal dopamine release using a nongenetically encoded near infrared fluorescent catecholamine nanosensor. [PDF]

, 2019
Neuromodulation plays a critical role in brain function in both health and disease, and new tools that capture neuromodulation with high spatial and temporal resolution are needed.
Beyene, Abraham G, Del Bonis-O'Donnell, Jackson Travis, Delevich, Kristen, Kosillo, Polina, Landry, Markita P, Lin, Wan Chen, Piekarski, David J, Prounis, George S, Thomas, A Wren, Wilbrecht, Linda, Yang, Darwin, Yang, Sarah J   +11 more
core   +1 more source

Palatable‐Food–Driven Top‐Down Circuit Inhibits PVNCRF Activity to Mitigate Stress Via Peri‐PVNCRFR1 Neurons

Advanced Science, EarlyView.
Palatable food alleviates stress and prevents anxiety. This study uncovers a dedicated neural pathway: dopamine release in the PFC activates D1R neurons, whose projections to the peri‐PVN engage a population of anxiolytic CRFR1 neurons. These neurons then inhibit stress‐induced hyperactivity of PVNCRF neurons, providing a circuit‐level explanation for ...
Yuchuan Hong, Shirui Jun, Tianjiao Deng, Gaojie Shao, Dan Liu, Yi Sun, Yan Chen, Qian Xiao, Jie Shao, Sheng Wang, Tianwen Huang, Fan Yang, Jie Tu   +12 more
wiley   +1 more source

Unraveling the mystery: How autophagy deficiency in dopaminergic neurons drives human Parkinson’s disease

Molecular Brain
Alpha-synuclein (α-synuclein), a key component of Lewy body pathology, is a classical hallmark of Parkinson’s disease. In previous studies, our group has examined dopaminergic neuron-specific Atg7 autophagy-deficient mice, observing α-synuclein ...
Sachiko Noda, Nobutaka Hattori
doaj   +1 more source

Parkinson’s Disease, the Dopaminergic Neuron and Gammahydroxybutyrate [PDF]

Neurology and Therapy, 2018
The high energy demands of the substantia nigra pars compacta dopaminergic (DASNc) neurons render these neurons vulnerable to degeneration. These energy demands are a function of their long and extensively arborized axons and very large number of transmitter release sites, and are further augmented by their natural pacemaking activity.
openaire   +2 more sources

In Vivo Electrochemical Monitoring of Safinamide Pharmacokinetics in the Brain Explores Its Correlation With Vision‐Related Neuronal Activity

Advanced Science, EarlyView.
An electrochemical platform based on differential pulse amperometry enables real‐time, selective tracking of safinamide pharmacokinetics in the living brain with high spatiotemporal resolution. When integrated with electrophysiology, this approach reveals that drug‐induced suppression of vision‐related neuronal activity provides mechanistic insight ...
Xiaoke Nan, Chuqi Li, Qianhe Dai, Junlan Zhou, Lijiao Cao, Yuying Liu, Jinger Chen, Meiping Xiong, Yuhang Jiang, Xianchan Li   +9 more
wiley   +1 more source

Differential regulation of the Drosophila sleep homeostat by circadian and arousal inputs. [PDF]

, 2019
One output arm of the sleep homeostat in Drosophila appears to be a group of neurons with projections to the dorsal fan-shaped body (dFB neurons) of the central complex in the brain.
Elsheikh, Ahmed, Gurav, Adishthi S, Hackbart, Hannah, Liu, Weiwei, Montell, Craig, Ni, Jinfei D, Ogunmowo, Tyler H, Verdegaal, Andrew A   +7 more
core   +1 more source

Automating AI Discovery for Biomedicine Through Knowledge Graphs and Large Language Models Agents

Advanced Intelligent Discovery, EarlyView.
This work proposes a novel framework that automates biomedical discovery by integrating knowledge graphs with multiagent large language models. A biologically aligned graph exploration strategy identifies hidden pathways between biomedical entities, and specialized agents use this pathway to iteratively design AI predictors and wet‐lab validation ...
Naafey Aamer, Muhammad Nabeel Asim, Shan Munir, Andreas Dengel   +3 more
wiley   +1 more source

Biofilm proficient Bacillus subtilis prevents neurodegeneration in Caenorhabditis elegans Parkinson’s disease models via PMK-1/p38 MAPK and SKN-1/Nrf2 signaling

Scientific Reports
Parkinson’s disease (PD) is a no-curable neurodegenerative disease of pandemic distribution for which only palliative treatments are available. A hallmark of PD is injury to dopaminergic neurons in the substantia nigra pars compacta. Here, we report that
Marcos Francisco, Roberto Grau
doaj   +1 more source

Driver Behavior Modeling with Subjective Risk‐Driven Inverse Reinforcement Learning

Advanced Intelligent Systems, EarlyView.
A subjective risk‐driven inverse reinforcement learning framework is proposed to model driver decision‐making. It infers drivers' risk perception and risk tolerance from driving data. A learnable risk threshold is used to regulate decisions, enabling interpretable and human‐like driving behavior decisions.
Yang Liang, Zichao Wang, Zhiwei He, Qingquan Wei, Yong Zuo, Linzhen Nie, Zhishuai Yin   +6 more
wiley   +1 more source

Neuronal deletion of the circadian clock gene Bmal1 induces cell-autonomous dopaminergic neurodegeneration

JCI Insight
Circadian rhythm dysfunction is a hallmark of Parkinson disease (PD), and diminished expression of the core clock gene Bmal1 has been described in patients with PD. BMAL1 is required for core circadian clock function but also serves nonrhythmic functions.
Michael F. Kanan, Patrick W. Sheehan, Jessica N. Haines, Pedro G. Gomez, Adya Dhuler, Collin J. Nadarajah, Zachary M. Wargel, Brittany M. Freeberg, Hemanth R. Nelvagal, Mariko Izumo, Joseph S. Takahashi, Jonathan D. Cooper, Albert A. Davis, Erik S. Musiek   +13 more
doaj   +1 more source