Results 131 to 140 of about 65,347 (261)

Acute Modafinil Exposure Induces Neurobehavioral Alterations in Zebrafish: Implications for Off‐Label Cognitive Enhancement

Journal of Applied Toxicology, EarlyView.
ABSTRACT Modafinil (2‐(benzhydrylsulfinyl)acetamide) is a psychostimulant commonly prescribed for sleep disorders such as narcolepsy, excessive daytime sleepiness, and obstructive sleep apnea. Recently, its use has extended beyond clinical indications, with neurotypical individuals adopting it as a smart drug to enhance alertness and cognitive ...
Luciane Dellazari da Silva do Prado, Nicole Berton, Nicoli da Rosa Amaral, Inara Carbonera Biazus, Laíse Mattiollo, Jéssica Nardi, Karen Júlia de Souza dos Santos, Natália Freddo, Leonardo José Gil Barcellos, Luciana Grazziotin Rossato‐Grando   +9 more
wiley   +1 more source

TMBIM6 enhances dopaminergic neuron survival by modulating the IRE1a pathway in Parkinson's disease. [PDF]

Cell Death Dis
Ahumada-Montalva P, Muñoz-Carvajal F, Bórquez-Macaya S, Arévalo-Ramírez N, Cisternas-Olmedo M, Jerez C, Urbina-Muñoz V, Gomez W, Urrutia PJ, Hirsch EC, Ahumada M, Barrias P, Muñoz-Yañez C, Herrera-Vásquez A, Arriagada G, Woehlbier U, Calegaro-Nassif M, Sanhueza M, Vidal RL, Rojas-Rivera D.   +19 more
europepmc   +1 more source

Developmental and Behavioral Effects of Arsenobetaine in Zebrafish (Danio rerio)

Journal of Applied Toxicology, EarlyView.
ABSTRACT Arsenobetaine (AsB) is a prevalent organoarsenical in aquatic environments and is generally regarded as nontoxic. Despite its widespread occurrence, the developmental and neurobehavioral toxicity of AsB has not been systematically investigated.
Sravan Kumar Putnala, Prerita Sharma, Prannav Jain, Samira Leila Baldin, Owen Luo, A. K. M. Munzurul Hasan, Md Helal Uddin, Mahesh Rachamalla, Som Niyogi   +8 more
wiley   +1 more source

Gut microbiota-derived TNF-α triggers dopaminergic neuron ferroptosis via TNFR1-NF-κB-ATF4 axis in Parkinson's disease. [PDF]

Cell Death Discov
Zhang Z, Zhong S, Gao L, Chen B, Huang P.   +4 more
europepmc   +1 more source

Potential Neuroendocrine Disruption by Benzodiazepines and Its Impact on Male Fertility

Journal of Applied Toxicology, EarlyView.
ABSTRACT Neuroactive substances have emerged as potent endocrine disruptors affecting male reproductive health through central and peripheral mechanisms. Among these, benzodiazepines, which are widely used for the management of anxiety, insomnia, epilepsy, and neuromuscular disorders, are known as GABA A (gamma‐aminobutyric acid type A) receptor ...
Ana Clara Melo Andrade de Rodrigues, Julia Gonçalves Rodrigues, Marcos de Lucca Moreira Gomes, Fernanda Carolina Ribeiro Dias   +3 more
wiley   +1 more source

Super-twisting sliding mode control of dopamine release in VTA dopaminergic neuron model: a simulation study. [PDF]

Sci Rep
Soheilipour N, Akhavan A, Rouhani E, Rahimi R.   +3 more
europepmc   +1 more source

Adverse Effects of Unsaturated Organic Compounds on Kinetic States During Locomotion Uncovered by Comprehensive Analysis of Behavioral Toxicities in C. elegans

Journal of Applied Toxicology, EarlyView.
ABSTRACT Organisms in human living spaces are surrounded by a variety of engineered substances. These chemical compounds have unexpected effects on the environment and human health. In particular, workers in industries face the risk of a health hazard caused by high‐dose or long‐term exposure to chemicals in the workplace.
Masahiro Tomioka
wiley   +1 more source

ZFHX4 is necessary for dopaminergic neuron differentiation and controls cell cycle by regulating LIN28A. [PDF]

Stem Cell Reports
Valceschini E, Gomez Ramos B, Ohnmacht J, Ginolhac A, Catillon M, Gerard D, Gaigneaux A, Kyriakis D, Grzyb K, Glaab E, Grünewald A, Skupin A, Sauter T, Krüger R, Sinkkonen L.   +14 more
europepmc   +1 more source

Reward processing in children with affective dysregulation

JCPP Advances, EarlyView.
Abstract Background Affective dysregulation (AD) in children is characterized by irritability, anger, and frequent intense temper outbursts. Considerable evidence implies altered processing of frustration about missed rewards, but few studies investigated the preceding and thus potentially predictive reward anticipation and initial delivery processing ...
Pascal‐M. Aggensteiner, Francisca Giller, Nathalie Holz, Anna Kaiser, Christine Igel, Sarah Hohmann, Manfred Döpfner, Veit Roessner, Christian Beste, Tobias Banaschewski, Daniel Brandeis, on behalf ofthe ADOPT Consortium   +11 more
wiley   +1 more source

Distinct radial glia subtypes regulate midbrain dopaminergic neuron development. [PDF]

Nat Neurosci
Ásgrímsdóttir ES, Bassini LF, Sun T, Puigsasllosas Pastor C, di Val Cervo PR, Gyllborg D, Lee K, Grigsby CL, Jude B, Abaurre C, Islam S, Lönnerberg P, Villaescusa C, Saltó C, Barker RA, Linnarsson S, Castelo-Branco G, La Manno G, Toledo EM, Arenas E.   +19 more
europepmc   +1 more source