Results 1 to 10 of about 835,219 (281)
Primary culture of mouse dopaminergic neurons. [PDF]
Journal of Visualized Experiments, 2014 Dopaminergic neurons represent less than 1% of the total number of neurons in the brain. This low amount of neurons regulates important brain functions such as motor control, motivation, and working memory.
F. Gaven, P. Marin, S. Claeysen
semanticscholar +5 more sources
Disinhibition Bursting of Dopaminergic Neurons [PDF]
Frontiers in Systems Neuroscience, 2011 Substantia nigra pars compacta (SNpc) dopaminergic neurons receive strong tonic inputs from GABAergic neurons in the substantia nigra pars reticulata (SNpr) and globus pallidus (GP), and glutamatergic neurons in the subthalamic nucleus.
Collin J Lobb +3 more
doaj +4 more sources
Transcription Factor-Mediated Generation of Dopaminergic Neurons from Human iPSCs—A Comparison of Methods [PDF]
CellsDopaminergic neurons are the predominant brain cells affected in Parkinson’s disease. With the limited availability of live human brain dopaminergic neurons to study pathological mechanisms of Parkinson’s disease, dopaminergic neurons have been generated
Kirstin O. McDonald +6 more
doaj +2 more sources
Necrostatin-1 protection of dopaminergic neurons
Neural Regeneration Research, 2015 Necroptosis is characterized by programmed necrotic cell death and autophagic activation and might be involved in the death process of dopaminergic neurons in Parkinson′s disease.
Jing-ru Wu +6 more
semanticscholar +5 more sources
Physiological characterisation of human iPS-derived dopaminergic neurons.
PLoS ONE, 2014 Human induced pluripotent stem cells (hiPSCs) offer the potential to study otherwise inaccessible cell types. Critical to this is the directed differentiation of hiPSCs into functional cell lineages.
Elizabeth M Hartfield +6 more
doaj +2 more sources
Frontiers in Neuroanatomy, 2014 Calbindin (CB) is a calcium binding protein reported to protect dopaminergic neurons from degeneration. Although a direct link between CB content and differential vulnerability of dopaminergic neurons has long been accepted, factors other than CB have ...
Iria G Dopeso-Reyes +14 more
doaj +2 more sources
Deficiency of orexin receptor type 1 in dopaminergic neurons increases novelty-induced locomotion and exploration [PDF]
eLifeOrexin signaling in the ventral tegmental area and substantia nigra promotes locomotion and reward processing, but it is not clear whether dopaminergic neurons directly mediate these effects.
Xing Xiao +6 more
doaj +2 more sources
Spatial and temporal distribution of dopaminergic neurons during development in zebrafish
Frontiers in Neuroanatomy, 2016 As one of the model organisms of Parkinson’s disease (PD) research, the zebrafish has its advantages, such as the 87% homology with human genome and transparent embryos which make it possible to observe the development of dopaminergic neurons in real ...
Yuchen Du +16 more
doaj +2 more sources
Calbindin and Girk2/Aldh1a1 define resilient vs vulnerable dopaminergic neurons in a primate Parkinson’s disease model [PDF]
npj Parkinson's DiseaseThe differential vulnerability of dopaminergic neurons of the substantia nigra pars compacta (SNc) is a critical and unresolved question in Parkinson´s disease.
Natalia López-González del Rey +10 more
doaj +2 more sources
Proceedings of the National Academy of Sciences of the United States of America, 2002 Although implantation of fetal dopamine (DA) neurons can reduce parkinsonism in patients, current methods are rudimentary, and a reliable donor cell source is lacking.
Lars M. Björklund +10 more
openalex +2 more sources