Results 1 to 10 of about 106,201 (265)

Human midbrain organoids reveal the characteristics of axonal mitochondria specific to dopaminergic neurons [PDF]

Molecular Brain
Mitochondrial dysfunction and abnormalities in mitochondrial quality control contribute to the development of neurodegenerative diseases. Parkinson’s disease is a neurodegenerative disease that causes motor problems mainly due to the loss of dopaminergic
Akihiko Nishijima, Mutsumi Yokota, Soichiro Kakuta, Akihiro Yamaguchi, Kei-ichi Ishikawa, Hideyuki Okano, Wado Akamatsu, Nobutaka Hattori, Masato Koike   +8 more
doaj   +2 more sources

Establishment of an in vitro model for analyzing mitochondrial ultrastructure in PRKN-mutated patient iPSC-derived dopaminergic neurons

Molecular Brain, 2021
Mitochondrial structural changes are associated with the regulation of mitochondrial function, apoptosis, and neurodegenerative diseases. PRKN is known to be involved with various mechanisms of mitochondrial quality control including mitochondrial ...
Mutsumi Yokota, Soichiro Kakuta, Takahiro Shiga, Kei-ichi Ishikawa, Hideyuki Okano, Nobutaka Hattori, Wado Akamatsu, Masato Koike   +7 more
doaj   +1 more source

Sustained chemogenetic activation of locus coeruleus norepinephrine neurons promotes dopaminergic neuron survival in synucleinopathy

PLoS ONE, 2022
Dopaminergic neuron degeneration in the midbrain plays a pivotal role in motor symptoms associated with Parkinson’s disease. However, non-motor symptoms of Parkinson’s disease and post-mortem histopathology confirm dysfunction in other brain areas ...
Predrag Jovanovic, Yidan Wang, Jean-Philippe Vit, Edward Novinbakht, Nancy Morones, Elliot Hogg, Michele Tagliati, Celine E. Riera   +7 more
doaj   +2 more sources

Co-Expression of Nogo-A in Dopaminergic Neurons of the Human Substantia Nigra Pars Compacta Is Reduced in Parkinson’s Disease

Cells, 2021
Parkinson’s disease is mainly characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta. Together with the small number, the high vulnerability of the dopaminergic neurons is a major pathogenic culprit of Parkinson’
Gian-Carlo Eyer, Stefano Di Santo, Ekkehard Hewer, Lukas Andereggen, Stefanie Seiler, Hans Rudolf Widmer   +5 more
doaj   +1 more source

Endoplasmic Reticulum Stress Is Associated with the Mesencephalic Dopaminergic Neuron Injury in Stressed Rats

Analytical Cellular Pathology, 2021
An increasing number of people are in a state of stress due to social and psychological pressures, which may result in mental disorders. Previous studies indicated that mesencephalic dopaminergic neurons are associated with not only reward-related ...
Shiba Niu, Weibo Shi, Yingmin Li, Shanyong Yi, Yang Li, Xia Liu, Bin Cong, Guanglong He   +7 more
doaj   +1 more source

Dopaminergic nuclei in the chick midbrain express serotonin receptor subfamily genes

Frontiers in Physiology, 2022
Serotonin (5-hydroxytryptamine, 5-HT) is a phylogenetically conserved modulator of numerous aspects of neural functions. Serotonergic neurons in the dorsal and median raphe nucleus provide ascending innervation to the entire forebrain and midbrain ...
Toshiyuki Fujita, Naoya Aoki, Chihiro Mori, Shouta Serizawa, Fumiko Kihara-Negishi, Koichi J. Homma, Shinji Yamaguchi   +6 more
doaj   +1 more source

Disinhibition Bursting of Dopaminergic Neurons [PDF]

Frontiers in Systems Neuroscience, 2011
Substantia nigra pars compacta (SNpc) dopaminergic neurons receive strong tonic inputs from GABAergic neurons in the substantia nigra pars reticulata (SNpr) and globus pallidus (GP), and glutamatergic neurons in the subthalamic nucleus. The presence of these tonic inputs raises the possibility that phasic disinhibition may trigger phasic bursts in ...
Lobb, Collin J., Troyer, Todd W., Wilson, Charles J., Paladini, Carlos A.   +3 more
openaire   +3 more sources

Dopaminergic regulation of orexin neurons [PDF]

European Journal of Neuroscience, 2005
AbstractOrexin/hypocretin neurons in the lateral hypothalamus and adjacent perifornical area (LH/PFA) innervate midbrain dopamine (DA) neurons that project to corticolimbic sites and subserve psychostimulant‐induced locomotor activity. However, it is not known whether dopamine neurons in turn regulate the activity of orexin cells.
Bubser, Michael, Fadel, Jim R., Jackson, Lela L., Meador-Woodruff, James H., Jing, Deqiang, Deutch, Ariel Y.   +5 more
openaire   +3 more sources

Function and Regulation of ALDH1A1-Positive Nigrostriatal Dopaminergic Neurons in Motor Control and Parkinson’s Disease

Frontiers in Neural Circuits, 2021
Dopamine is an important chemical messenger in the brain, which modulates movement, reward, motivation, and memory. Different populations of neurons can produce and release dopamine in the brain and regulate different behaviors.
Kathleen Carmichael, Kathleen Carmichael, Rebekah C. Evans, Rebekah C. Evans, Elena Lopez, Lixin Sun, Mantosh Kumar, Jinhui Ding, Zayd M. Khaliq, Huaibin Cai   +9 more
doaj   +1 more source

Primary Culture of Mouse Dopaminergic Neurons [PDF]

Journal of Visualized Experiments, 2014
Dopaminergic neurons represent less than 1% of the total number of neurons in the brain. This low amount of neurons regulates important brain functions such as motor control, motivation, and working memory. Nigrostriatal dopaminergic neurons selectively degenerate in Parkinson's disease (PD).
Gaven, Florence, Marin, Philippe, Claeysen, Sylvie   +2 more
openaire   +2 more sources