Results 91 to 100 of about 835,318 (379)

Cell cycle and p53 gate the direct conversion of human fibroblasts to dopaminergic neurons

Nature Communications, 2015
The direct conversion of fibroblasts to induced dopaminergic (iDA) neurons and other cell types demonstrates the plasticity of cell fate. The low efficiency of these relatively fast conversions suggests that kinetic barriers exist to safeguard cell-type ...
Houbo Jiang, Zhimin Xu, P. Zhong, Yong Ren, Gaoyang Liang, Haley A. Schilling, Zihua Hu, Yi Zhang, Xiaomin Wang, Shengdi Chen, Zhen Yan, Jian Feng   +11 more
semanticscholar   +1 more source

Activation of Glutamatergic Neurons in the Supramammillary Nucleus Promotes the Recovery of Consciousness under Sevoflurane Anesthesia

Advanced Science, EarlyView.
Selective lesioning of SuM glutamatergic neurons promoted the induction of and delayed emergence from sevoflurane anesthesia and increased sevoflurane sensitivity. Optogenetic stimulation of SuM glutamatergic neurons or the SuM‐MS projection promoted behavioral arousal and cortical activation under steady‐state sevoflurane anesthesia and reduced the ...
Jiayan Li, Yehui Wu, Yihan Wang, Yumin Wu, Rong Hu, Si Long, Wenqi Huang, Liming Nie, Zhongxing Wang   +8 more
wiley   +1 more source

New insights into glioma frequency maps: From genetic and transcriptomic correlate to survival prediction

International Journal of Cancer, Volume 152, Issue 5, Page 998-1012, 1 March 2023., 2023
What's new? The spatial distribution of glioma is nonrandom. However, whether pathological grade influences glioma distribution across the brain remains unclear. Here, the authors built a population‐based frequency map for 396 patients with glioblastoma multiforme and 190 patients with lower‐grade glioma, revealing their distinct topographic ...
Hongbo Bao, Peng Ren, Liye Yi, Zhonghua Lv, Wencai Ding, Chenlong Li, Siyang Li, Zhipeng Li, Xue Yang, Xia Liang, Peng Liang   +10 more
wiley   +1 more source

Phenotypic Reprogramming of Striatal Neurons into Dopaminergic Neuron-like Cells in the Adult Mouse Brain

Stem Cell Reports, 2018
Summary: Neuronal subtype is largely fixed in the adult mammalian brain. Here, however, we unexpectedly reveal that adult mouse striatal neurons can be reprogrammed into dopaminergic neuron-like cells (iDALs). This in vivo phenotypic reprogramming can be
Wenze Niu, Tong Zang, Lei-Lei Wang, Yuhua Zou, Chun-Li Zhang   +4 more
doaj  

Motor skill learning and reward consumption differentially affect VTA activation

Scientific Reports, 2018
Dopamine release from the ventral tegmental area (VTA) terminals in the primary motor cortex (M1) enables motor skill acquisition. Here, we test the hypothesis that dopaminergic VTA neurons projecting to M1 are activated when rewards are obtained during ...
Susan Leemburg, Tara Canonica, Andreas Luft   +2 more
doaj   +1 more source

Sequential loss of LC noradrenergic and dopaminergic neurons results in a correlation of dopaminergic neuronal number to striatal dopamine concentration

Frontiers in Pharmacology, 2012
Noradrenergic neurons in the locus coeruleus (LC) are significantly reduced in Parkinson’s disease (PD) and the LC exhibits neuropathological changes early in the disease process.
Patricia eSzot, Patricia eSzot, Allyn eFranklin, Carl eSikkema, Charles W Wilkinson, Charles W Wilkinson, Murray A Raskind, Murray A Raskind   +7 more
doaj   +1 more source

Parkinsons Disease Detection via Resting-State Electroencephalography Using Signal Processing and Machine Learning Techniques [PDF]

arXiv, 2023
Parkinsons Disease (PD) is a neurodegenerative disorder resulting in motor deficits due to advancing degeneration of dopaminergic neurons. PD patients report experiencing tremor, rigidity, visual impairment, bradykinesia, and several cognitive deficits. Although Electroencephalography (EEG) indicates abnormalities in PD patients, one major challenge is
arxiv  

Glutamatergic and dopaminergic neurons in the mouse ventral tegmental area

European Journal of Neuroscience, 2015
The ventral tegmental area (VTA) comprises dopamine (DA), γ‐aminobutyric acid (GABA) and glutamate (Glu) neurons. Some rat VTA Glu neurons, expressing vesicular glutamate transporter 2 (VGluT2), co‐express tyrosine hydroxylase (TH). While transgenic mice
Tsuyoshi Yamaguchi, J. Qi, Huiling Wang, Shiliang Zhang, M. Morales   +4 more
semanticscholar   +1 more source

α‐Synuclein Pathology Spreads in a Midbrain–Hindbrain Assembloid Model

Advanced Science, EarlyView.
A novel midbrain–hindbrain assembloid model demonstrates the spread of α‐synuclein pathology, a hallmark of Parkinson's disease, mimicking Braak's hypothesis. This model reveals how pathology propagates from the hindbrain to the midbrain, inducing synaptic changes and early signs of neuronal vulnerability. It offers an innovative platform for exploring
Gemma Gomez‐Giro, Daniela Frangenberg, Daniela Vega, Alise Zagare, Kyriaki Barmpa, Paul M. A. Antony, Graham Robertson, Rahman Sabahi‐Kaviani, Kristian Haendler, Nathalie Kruse, Florentia Papastefanaki, Rebecca Matsas, Malte Spielmann, Regina Luttge, Jens C. Schwamborn   +14 more
wiley   +1 more source

Dopaminergic neurons promote hippocampal reactivation and spatial memory persistence

Nature Neuroscience, 2014
We found that optogenetic burst stimulation of hippocampal dopaminergic fibers from midbrain neurons in mice exploring novel environments enhanced the reactivation of pyramidal cell assemblies during subsequent sleep/rest.
Colin G. McNamara, Álvaro Tejero-Cantero, S. Trouche, Natalia Campo-Urriza, D. Dupret   +4 more
semanticscholar   +1 more source