Results 101 to 110 of about 835,318 (379)

Dopaminergic Modulation of Spinal Neuronal Excitability [PDF]

The Journal of Neuroscience, 2007
It is well recognized that dopamine (DA) can modulate spinal networks and reflexes. DA fibers and receptors are present in the spinal cord, and evidence for DA release within the spinal cord has been published. A critical gap is the lack of data regarding dopaminergic modulation of intrinsic and synaptic properties of motoneurons and ventral ...
Patrick J. Whelan, Michelle A. Tran, Pengcheng Han, Stan T. Nakanishi   +3 more
openaire   +3 more sources

SIRT3‐Mediated Deacetylation of DRP1K711 Prevents Mitochondrial Dysfunction in Parkinson's Disease

Advanced Science, EarlyView.
SIRT3‐mediated deacetylation of DRP1 at K711 resists mitochondrial dysfunction and DA neuronal death in PD, uncovering a treatment target. Abstract Dysregulation of mitochondrial dynamics is a key contributor to the pathogenesis of Parkinson's disease (PD).
Ye Xi, Kai Tao, Xiaomin Wen, Dayun Feng, Zifan Mai, Hui Ding, Honghui Mao, Mingming Wang, Qian Yang, Jie Xiang, Jie Zhang, Shengxi Wu   +11 more
wiley   +1 more source

Integrated brain on a chip and automated organ‐on‐chips systems

Interdisciplinary Medicine, Volume 1, Issue 1, January 2023., 2023
Organ‐on‐chips (OOCs) related to brain functions have been used in drug development and disease simulation in vitro. However, modeling of complex biological systems remains a major challenge. In this paper, the compositions of the OOCs are optimized, and an automatic integrated system model is designed. It is expected to boost life science research and
Zhe Li, Yimeng Zhao, Xuefei Lv, Yulin Deng   +3 more
wiley   +1 more source

The dopaminergic system in the aging brain of Drosophila

Frontiers in Neuroscience, 2010
Drosophila models of Parkinson’s disease are characterised by two principal phenotypes: the specific loss of dopaminergic neurons in the aging brain and defects in motor behavior.
Katherine E White, Dickon M Humphrey, Frank eHirth   +2 more
doaj   +1 more source

TRPC4 ion channel protein is selectively expressed in a subpopulation of dopamine neurons in the ventral tegmental area [PDF]

, 2012
The nonselective cation channel TRPC4 has been shown to be present in high abundance in the corticolimbic regions of the brain and play a pivotal role in modulating cellular excitability due to their involvement in intracellular Ca2+ regulation. Recently we reported their involvement in socialization and regulating anxiety-like behaviors in rats. Given
arxiv   +1 more source

Deep brain stimulation with a computational model for the cortex-thalamus-basal-ganglia system and network dynamics of neurological disorders [PDF]

arXiv, 2021
Deep brain stimulation (DBS) can alleviate the movement disorders like Parkinson's disease (PD). Indeed, it is known that aberrant beta (13-30Hz)oscillations and the loss of dopaminergic neurons in the basal ganglia-thalamus (BGTH) and cortex characterize the akinesia symptoms of PD. However, the relevant biophysical mechanism behind this process still
arxiv  

A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

Proceedings of the National Academy of Sciences of the United States of America, 1983
A syndrome similar to idiopathic parkinsonism developed after intravenous self-administration of an illicit drug preparation in which N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (NMPTP) might have been responsible for the toxicity.
Burns Rs, C. Chiueh, S. Markey, M. Ebert, D. Jacobowitz, I. Kopin   +5 more
semanticscholar   +1 more source

Implantable Self‐Powered Systems for Electrical Stimulation Medical Devices

Advanced Science, EarlyView.
In this paper, the design strategy and clinical application of ISS are discussed in depth from four aspects: the design and optimization of the energy collection module, the selection and preparation of adaptive electrode materials, the innovation of system design strategy, and the biological effect of electrical stimulation of ISS.
Xi Cui, Li Wu, Chao Zhang, Zhou Li
wiley   +1 more source

Chronic stress enhances microglia activation and exacerbates death of nigral dopaminergic neurons under conditions of inflammation

Journal of Neuroinflammation, 2014
BackgroundParkinson’s disease is an irreversible neurodegenerative disease linked to progressive movement disorders and is accompanied by an inflammatory reaction that is believed to contribute to its pathogenesis.
R. M. de Pablos, A. J. Herrera, A. M. Espinosa-Oliva, Manuel Sarmiento, Mario F. Muñoz, A. Machado, J. L. Venero   +6 more
semanticscholar   +1 more source

Massage‐Mimicking Nanosheets Mechanically Reorganize Inter‐organelle Contacts to Restore Mitochondrial Functions in Parkinson's Disease

Advanced Science, EarlyView.
Parkinson's disease (PD) progression is aggravated by disrupted inter‐organelle contacts, which are influenced by mechanical forces. NanoMassage, 200 nm PEGylated black phosphorus nanosheets, deliver targeted mechanical stimulation to neural cells.
Tianqi Li, Liwen Huang, Chenxiao Guo, Jing Ren, Xi Chen, Yachu Ke, Zengyu Xun, Wenzhuo Hu, Yilin Qi, Heping Wang, Zhongying Gong, Xing‐Jie Liang, Xue Xue   +12 more
wiley   +1 more source