Results 111 to 120 of about 835,318 (379)

Projections of the Diencephalospinal Dopaminergic System to Peripheral Sense Organs in Larval Zebrafish (Danio rerio)

Frontiers in Neuroanatomy, 2018
Dopaminergic neurons of the descending diencephalospinal system are located in the posterior tuberculum (PT) in zebrafish (Danio rerio), and correspond in mammals to the A11 group in hypothalamus and thalamus. In the larval zebrafish, they are likely the
Melanie Haehnel-Taguchi, António M. Fernandes, António M. Fernandes, Margit Böhler, Ina Schmitt, Lena Tittel, Wolfgang Driever, Wolfgang Driever   +7 more
doaj   +1 more source

Altered Neural Activity in the Mesoaccumbens Pathway Underlies Impaired Social Reward Processing in Shank3‐Deficient Rats

Advanced Science, EarlyView.
This study examines the effects of Shank3 mutation on the mesoaccumbens pathway using a Shank3‐deficient rat model. The findings reveal altered social reward processing in these rats, accompanied by changes in dopaminergic and GABAergic neural activity within the ventral tegmental area (VTA) and dopamine release in the nucleus accumbense (NAc ...
Marie Barbier, Keerthi Thirtamara Rajamani, Shai Netser, Shlomo Wagner, Hala Harony‐Nicolas   +4 more
wiley   +1 more source

Environmental exposure of the general population to cadmium as a risk factor of the damage to the nervous system: A critical review of current data

Journal of Applied Toxicology, Volume 43, Issue 1, Page 66-88, January 2023., 2023
Abstract Nowadays, more and more attention has been focused on the risk of the neurotoxic action of cadmium (Cd) under environmental exposure. Due to the growing incidence of nervous system diseases, including neurodegenerative changes, and suggested involvement of Cd in their aetiopathogenesis, this review aimed to discuss critically this element ...
Agnieszka Ruczaj, Małgorzata M. Brzóska   +1 more
wiley   +1 more source

Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning

Science, 2009
Rewarding Bursts of Dopamine Dopaminergic neurons are thought to be involved in the cognitive and hedonic underpinnings of motivated behaviors. However, it is still unclear whether dopaminergic neuron activation is sufficient to elicit reward-related ...
T. Thesen, Chunmao Wang, O. Devinsky, R. Kuzniecky, W. Doyle, J. Madsen, E. Bromfield, L. Erőss, P. Halász, G. Karmos, Richárd Csercsa, L. Wittner, I. Ulbert   +12 more
semanticscholar   +1 more source

Utilizing Caenorhabditis Elegans as a Rapid and Precise Model for Assessing Amphetamine‐Type Stimulants: A Novel Approach to Evaluating New Psychoactive Substances Activity and Mechanisms

Advanced Science, EarlyView.
This study uses Caenorhabditis elegans to assess the activity of amphetamine‐type stimulants (ATS) and their analogs. The research highlights the roles of dopamine and serotonin pathways, distinguishes chiral forms of ATS, and identifies structure‐activity relationships. These findings provide a rapid and cost‐effective model for evaluating the effects
Yuanpeng Li, Hongyuan Li, Hongshuang Wang, Xiaohui Wang   +3 more
wiley   +1 more source

Motor cortical excitability and pre‐supplementary motor area neurochemistry in healthy adults with substantia nigra hyperechogenicity

Journal of Neuroscience Research, Volume 101, Issue 2, Page 263-277, February 2023., 2023
Substantia nigra (SN) hyperechogenicity, viewed with transcranial ultrasound, is a risk marker for Parkinson's disease. SN hyperechogenicity in healthy older adults is associated with changes in the excitability of specific motor cortical circuitry. These changes are unrelated to glutamate levels in the pre‐supplementary motor area (pre‐SMA).
Gabrielle Todd, Caroline D. Rae, Janet L. Taylor, Nigel C. Rogasch, Jane E. Butler, Michael Hayes, Robert A. Wilcox, Simon C. Gandevia, Karl Aoun, Adrian Esterman, Simon J. G. Lewis, Julie M. Hall, Elie Matar, Jana Godau, Daniela Berg, Christian Plewnia, Anna‐Katharina von Thaler, Clarence Chiang, Kay L. Double   +18 more
wiley   +1 more source

miR-34b/c Regulates Wnt1 and Enhances Mesencephalic Dopaminergic Neuron Differentiation

Stem Cell Reports, 2018
Summary: The differentiation of dopaminergic neurons requires concerted action of morphogens and transcription factors acting in a precise and well-defined time window. Very little is known about the potential role of microRNA in these events.
Roberto De Gregorio, Salvatore Pulcrano, Claudia De Sanctis, Floriana Volpicelli, Ezia Guatteo, Lars von Oerthel, Emanuele Claudio Latagliata, Roberta Esposito, Rosa Maria Piscitelli, Carla Perrone-Capano, Valerio Costa, Dario Greco, Stefano Puglisi-Allegra, Marten P. Smidt, Umberto di Porzio, Massimiliano Caiazzo, Nicola Biagio Mercuri, Meng Li, Gian Carlo Bellenchi   +18 more
doaj  

Analysis of pacemaker activity in a two-component model of some brainstem neurons [PDF]

arXiv, 2017
Serotonergic, noradrenergic and dopaminergic brainstem (including midbrain) neurons, often exhibit spontaneous and fairly regular spiking with frequencies of order a few Hz, though dopaminergic and noradrenergic neurons only exhibit such pacemaker-type activity in vitro or in vivo under special conditions.
arxiv  

Mechanisms explaining transitions between tonic and phasic firing in neuronal populations as predicted by a low dimensional firing rate model [PDF]

, 2010
Several firing patterns experimentally observed in neural populations have been successfully correlated to animal behavior. Population bursting, hereby regarded as a period of high firing rate followed by a period of quiescence, is typically observed in groups of neurons during behavior.
arxiv   +1 more source

Fibroblast growth factor-21 enhances mitochondrial functions and increases the activity of PGC-1α in human dopaminergic neurons via Sirtuin-1

SpringerPlus, 2014
Mitochondrial dysfunctions accompany several neurodegenerative disorders and contribute to disease pathogenesis among others in Parkinson’s disease (PD).
Johanna Mäkelä, Timofey V. Tselykh, F. Maiorana, O. Eriksson, H. T. Do, G. Mudó, L. Korhonen, N. Belluardo, D. Lindholm   +8 more
semanticscholar   +1 more source