Results 121 to 130 of about 835,318 (379)

Microenvironmental Modulation for Therapeutic Efficacy of Extracellular Vesicles

Advanced Science, EarlyView.
Recent studies highlighted the heterogeneity of EVs and the influence of microenvironmental signals on their therapeutic efficacy. This review offers a comprehensive overview of strategies and mechanisms to optimize the therapeutic efficacy of EVs through physical, biochemical, and mechanical modulation.
Bilu Xiang, Shiying Zhang, Irene Shuping Zhao, Xueqi Gan, Yang Zhang   +4 more
wiley   +1 more source

The Locus Coeruleus‐Periaqueductal Gray GABAergic Projection Regulates Comorbid Pain and Depression

Advanced Science, EarlyView.
LC‐GABA neurons exhibit elevated activity to noxious and aversive stimuli in chronic pain, and their activation alleviates pain‐ and depression‐like behaviors. While LC‐GABA neurons target LC‐NA neurons and GABA and Glu neurons in the vlPAG, they modulate the pain responses of LC‐NA neurons but regulate pain‐ and depression‐like behaviors through their
Yuan Gao, Xue Zhang, Xiao‐Juan Liu, Yi‐Ling Sun, Cui Yin, Dong‐Liang Tang, Cheng Xiao, Chunyi Zhou   +7 more
wiley   +1 more source

LIBX‐A401: A Novel Selective Inhibitor of Acyl‐CoA Synthetase Long Chain Family Member 4 (ACSL4) and Its Binding Mode

Angewandte Chemie, EarlyView.
The discovery of LIBX‐A401, a potent and selective ACSL4 inhibitor derived from rosiglitazone is reported. HDX‐MS reveals that LIBX‐A401 stabilizes the ACSL4 C‐terminus and alters the fatty acid (FA) gate domain. Consistently, photoaffinity labeling, molecular dynamics, and mutagenesis identify key binding residues within the FA pocket.
Darius Mazhari Dorooee, Séverine Ravez, Didier Vertommen, Nicolas Renault, Nicolas Papadopoulos, Romain Marteau, Emeline Charnelle, Karine Porte, Alexandre Gobert, Nathalie Hennuyer, Gaetan Herinckx, Maëla Pautric, Aurélie Jonneaux, Jean Christophe Devedjian, David Devos, Bart Staels, Patricia Melnyk, Stefan N. Constantinescu, Raphaël Frédérick, Jamal El Bakali   +19 more
wiley   +2 more sources

The lifelong maintenance of mesencephalic dopaminergic neurons by Nurr1 and engrailed

Journal of Biomedical Sciences, 2014
Specific vulnerability and degeneration of the dopaminergic neurons in the substantia nigra pars compacta of the midbrain is the pathological hallmark of Parkinson’s disease.
Kambiz Alavian, Sharmin Jeddi, Sahar I Naghipour, Pegah Nabili, P. Licznerski, T. Tierney   +5 more
semanticscholar   +1 more source

Factors Associated With Anxiety Symptoms in Older Adults Attending an Outpatient Geriatric Service: A Cross‐Sectional Study

AGING MEDICINE, EarlyView.
An analytical study was carried out by secondary analysis of a database of a study performed between 2010 and 2015 at the Naval Medical Center of Peru (CEMENA). the analysis revealed that depressive symptoms, polypharmacy, slow gait speed, education, and marital status were significant contributors to anxiety in this population.
Gianella Grajeda‐León, Victoria Azurin‐Gonzales, Zulema Mamani‐Condori, Alvaro M. Ñaña‐Cordova, Marina A. Bustamante‐Ordoñez, Fiorella Neyra‐Cordova, José F. Parodi, Fernando M. Runzer Colmenares   +7 more
wiley   +1 more source

A Computational Model of the Effects of Drug Addiction on Neural Population Dynamics [PDF]

arXiv, 2012
Reward processing and derangements thereof, such as drug addiction, involve the coordinated activity of many brain areas. Prior work has identified many behavioral, molecular biological and single neuron changes throughout the mesocorticolimbic system that reflect and drive addictive behavior.
arxiv  

Designed Biomaterial‐Enhanced Cell Transplantation for Neural Tissue Engineering

Aggregate, EarlyView.
Biomaterials offer a promising solution for cell transplantation in the central nervous system by creating a protective environment that enhances cell survival, integration, and functional recovery in preclinical models of neurological disorders. ABSTRACT Cell transplantation therapy in the central nervous system is hindered by limited survival and ...
Yun Tang, Alice Le Friec, Menglin Chen, Di Sun   +3 more
wiley   +1 more source

Reduced complement of dopaminergic neurons in the substantia nigra pars compacta of mice with a constitutive “low footprint” genetic knockout of alpha-synuclein

Molecular Brain, 2020
Previous studies of the alpha-synuclein null mutant mice on the C57Bl6 genetic background have revealed reduced number of dopaminergic neurons in their substantia nigra pars compacta (SNpc).
Valeria V. Goloborshcheva, Kirill D. Chaprov, Ekaterina V. Teterina, Ruslan Ovchinnikov, Vladimir L. Buchman   +4 more
doaj   +1 more source

High level modeling of tonic dopamine mechanisms in striatal neurons [PDF]

arXiv, 2007
The extant versions of many basal ganglia models use a `gating' model of dopamine function which enhances input to D1 receptor units and attenuates input to D2 receptor units. There is evidence that this model is unsatisfactory because (a) there are not sufficient dopaminergic synapses to gate all input and (b) dopamine's main effect is likely to be on
arxiv  

Controlled Forgetting: Targeted Stimulation and Dopaminergic Plasticity Modulation for Unsupervised Lifelong Learning in Spiking Neural Networks [PDF]

, 2019
Stochastic gradient descent requires that training samples be drawn from a uniformly random distribution of the data. For a deployed system that must learn online from an uncontrolled and unknown environment, the ordering of input samples often fails to meet this criterion, making lifelong learning a difficult challenge.
arxiv   +1 more source