Results 191 to 200 of about 835,318 (379)

Computer‐aided Evaluation of Polyvalent Medications’ Pharmacological Potential. Multiphytoadaptogen as a Case Study

Molecular Informatics, Volume 42, Issue 1, January 2023., 2023
Abstract Many human diseases including cancer, degenerative and autoimmune disorders, diabetes and others are multifactorial. Pharmaceutical agents acting on a single target do not provide their efficient curation. Multitargeted drugs exhibiting pleiotropic pharmacological effects have certain advantages due to the normalization of the complex ...
O. A. Bocharova, N. S. Ionov, I. V. Kazeev, V. E. Shevchenko, E. V. Bocharov, R. V. Karpova, O. P. Sheychenko, A. A. Aksyonov, S. V. Chulkova, V. G. Kucheryanu, A. V. Revishchin, G. V. Pavlova, V. S. Kosorukov, D. A. Filimonov, A. A. Lagunin, V. B. Matveev, N. V. Pyatigorskaya, I. S. Stilidi, V. V. Poroikov   +18 more
wiley   +1 more source

Bayesian Approaches for Revealing Complex Neural Network Dynamics in Parkinson's Disease [PDF]

arXiv
Parkinson's disease (PD) belongs to the class of neurodegenerative disorders that affect the central nervous system. It is usually defined as the gradual loss of dopaminergic neurons in the substantia nigra pars compacta, which causes both motor and non-motor symptoms.
arxiv  

Effects of experimental cerebral ischemia on striatal dopaminergic neurons.

, 1989
Hiroshi Yao, Takao Ishitsuka, Seizo Sadoshima, Hideyuki Uchimura, Masatoshi Fujishima   +4 more
openalex   +2 more sources

Selective vulnerability of late-generated dopaminergic neurons of the substantia nigra in weaver mutant mice. [PDF]

, 1995
Shirley A. Bayer, Katherine V. Wills, L C Triarhou, Tatyana Verina, James D. Thomas, Bernardino Ghetti   +5 more
openalex   +1 more source

Nanomaterials for promoting axon regeneration after spinal cord injury: Mechanisms and prospects

Interdisciplinary Medicine, EarlyView.
The effects of clinical therapies for spinal cord injury (SCI) are greatly limited due to poor axon regeneration. This review systematically discusses the ability of nanomaterials (NMs) to treat SCI and the mechanism underlying their therapeutic effects. The properties of NMs that are conducive to axon regeneration after SCI are outlined.
Jia Liu, Zhendong Huang, Xiner Tan, Wei Du, Ziyang Wang, Xinru Zhou, Hao Pan, Lili Chen, Yiyuan Kang, Longquan Shao   +9 more
wiley   +1 more source

The hitochemical changes of non-dopaminergic neurons of the mouse striatum induced by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP), a nigrostriatal dopaminergic neurotoxin used for a model of Parkinson's disease

, 1986
Toshikazu Hochi
openalex   +2 more sources

Characterization of the Dopamine Defect in Primary Cultures of Dopaminergic Neurons from Hypoxanthine Phosphoribosyltransferase Knockout Mice [PDF]

, 2000
Doug W. Smith, Theodore Friedmann
openalex   +1 more source

Growth/Differentiation Factor-15/Macrophage Inhibitory Cytokine-1 Is a Novel Trophic Factor for Midbrain Dopaminergic NeuronsIn Vivo [PDF]

, 2000
Jens Strelau, Aideen M. Sullivan, Martina Böttner, Paul Lingor, Elisabeth Falkenstein, Clemens Suter‐Crazzolara, Dagmar Galter, József Jászai, Kerstin Krieglstein, Klaus Unsicker   +9 more
openalex   +1 more source

Promotion of central cholinergic and dopaminergic neuron differentiation by brain-derived neurotrophic factor but not neurotrophin 3.

, 1991
Beat Knüsel, John Winslow, Arnon Rosenthal, Louis E. Burton, Derice P. Seid, Károly Nikolics, Franz Hefti   +6 more
openalex   +1 more source

Polygenic Risk Score Combined with Transcranial Sonography Refines Parkinson's Disease Risk Prediction

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Dopaminergic neuron depletion in the substantia nigra (SN) and the pathological aggregation of α‐synuclein are the neuropathological hallmarks of Parkinson's disease (PD). Objectives This study aimed to investigate the association between the polygenic risk score for PD (PD‐PRS) and transcranial sonography (TCS)‐measured SN ...
Mart Kals, Anu Reigo, Maris Teder‐Laving, Mariliis Vaht, Estonian Biobank research team, Lili Milani, Reedik Mägi, Mari Nelis, Georgi Hudjašov, Tiit Nikopensius, Andres Metspalu, Toomas Toomsoo   +11 more
wiley   +1 more source