Results 41 to 50 of about 835,318 (379)

Self-supervised Learning for Segmentation and Quantification of Dopamine Neurons in Parkinson's Disease [PDF]

arXiv, 2023
Parkinson's Disease (PD) is the second most common neurodegenerative disease in humans. PD is characterized by the gradual loss of dopaminergic neurons in the Substantia Nigra (SN). Counting the number of dopaminergic neurons in the SN is one of the most important indexes in evaluating drug efficacy in PD animal models.
arxiv  

Generation of Functional Dopaminergic Neurons from Reprogramming Fibroblasts by Nonviral-based Mesoporous Silica Nanoparticles

Scientific Reports, 2018
Direct-lineage conversion of the somatic cell by reprogramming, in which mature cells were fully converted into a variety of other cell types bypassing an intermediate pluripotent state, is a promising regenerative medicine approach.
Jen-Hsuan Chang, P. Tsai, Kai-Yi Wang, Yu-Ting Wei, S. Chiou, C. Mou   +5 more
semanticscholar   +1 more source

Dopaminergic neurodegeneration in the substantia nigra is associated with olfactory dysfunction in mice models of Parkinson’s disease

Cell Death Discovery, 2023
Olfactory dysfunction represents a prodromal stage in Parkinson’s disease (PD). However, the mechanisms underlying hyposmia are not specified yet.
Yu Yuan, Xizhen Ma, Xiaoqing Mi, Le Qu, Meiyu Liang, Mengyu Li, Youcui Wang, Ning Song, Junxia Xie   +8 more
doaj   +1 more source

Achyranthes bidentata polypeptide protects dopaminergic neurons from apoptosis in Parkinson's disease models both in vitro and in vivo

British Journal of Pharmacology, 2018
Parkinson's disease (PD) is a neurodegenerative disorder closely associated with dopaminergic neuron loss. It is well documented that Achyranthes bidentata polypeptides (ABPP) are potent neuroprotective agents in several kinds of neurons.
S. Peng, Caiping Wang, Jinyu Ma, Ketao Jiang, Yuhui Jiang, X. Gu, Cheng Sun   +6 more
semanticscholar   +1 more source

Transcriptional regulation by nicotine in dopaminergic neurons [PDF]

Biochemical Pharmacology, 2013
Dopaminergic neurons in the substantia nigra pars compacta (SNc) degenerate in Parkinson's disease. These neurons robustly express several nicotinic acetylcholine receptor (nAChR) subtypes. Smoking appears to be neuroprotective for Parkinson's disease but the mechanism is unknown. To determine whether chronic nicotine-induced changes in gene expression
Henley, Beverley M., Williams, Brian A., Srinivasan, Rahul, Cohen, Bruce N., Xiao, Cheng, Mackey, Elisha D. W., Wold, Barbara J., Lester, Henry A.   +7 more
openaire   +5 more sources

Discovery of nigral dopaminergic neurogenesis in adult mice

Neural Regeneration Research, 2016
Parkinson′s disease is characterized by the loss of dopaminergic neurons in the substantia nigra. As a result, intensive efforts have focused upon mechanisms that facilitate the death of mature dopaminergic neurons. Unfortunately, these efforts have been
Brad E Morrison
doaj   +1 more source

Reduced ER-mitochondrial contact sites and mitochondrial Ca2+ flux in PRKN-mutant patient tyrosine hydroxylase reporter iPSC lines

Frontiers in Cell and Developmental Biology, 2023
Endoplasmic reticulum-mitochondrial contact sites (ERMCS) play an important role in mitochondrial dynamics, calcium signaling, and autophagy. Disruption of the ERMCS has been linked to several neurodegenerative diseases, including Alzheimer’s disease (AD)
Mutsumi Yokota, Yutaro Yoshino, Mitsuko Hosoi, Ryota Hashimoto, Soichiro Kakuta, Takahiro Shiga, Kei-Ichi Ishikawa, Kei-Ichi Ishikawa, Hideyuki Okano, Nobutaka Hattori, Nobutaka Hattori, Wado Akamatsu, Masato Koike   +12 more
doaj   +1 more source

Treg Cells Protect Dopaminergic Neurons against MPP+ Neurotoxicity via CD47-SIRPA Interaction

Cellular Physiology and Biochemistry, 2017
Background/Aims: Regulatory T (Treg) cells have been associated with neuroprotection by inhibiting microglial activation in animal models of Parkinson's disease (PD), a progressive neurodegenerative disease characterized by dopaminergic neuronal loss in ...
Yan Huang, Zhan Liu, Bei-Bei Cao, Yi-Hua Qiu, Yu-Ping Peng   +4 more
doaj   +1 more source

A New Glucocerebrosidase Chaperone Reduces α-Synuclein and Glycolipid Levels in iPSC-Derived Dopaminergic Neurons from Patients with Gaucher Disease and Parkinsonism

Journal of Neuroscience, 2016
Among the known genetic risk factors for Parkinson disease, mutations in GBA1, the gene responsible for the lysosomal disorder Gaucher disease, are the most common.
E. Aflaki, Daniel K. Borger, Nima Moaven, B. Stubblefield, S. Rogers, S. Patnaik, F. Schoenen, W. Westbroek, Wei Zheng, Patricia Sullivan, H. Fujiwara, Rohini Sidhu, Zayd M. Khaliq, G. Lopez, D. Goldstein, D. Ory, J. Marugan, E. Sidransky   +17 more
semanticscholar   +1 more source

Representation of spontaneous movement by dopaminergic neurons is cell-type selective and disrupted in parkinsonism

Proceedings of the National Academy of Sciences of the United States of America, 2016
Significance Deciphering the roles of midbrain dopaminergic neurons in the control of movement is critical not only for understanding of normal motor function but also for defining the basis of motor dysfunction in Parkinson’s disease.
Paul D. Dodson, J. Dreyer, K. Jennings, E. Syed, R. Wade-Martins, S. Cragg, J. Bolam, P. Magill, R. Malenka   +8 more
semanticscholar   +1 more source