Results 31 to 40 of about 3,606 (169)

The evolving role of structural biology in pharma: integration of X‐ray crystallography, cryo‐electron microscopy and beyond

open access: yesActa Crystallographica Section D, Volume 82, Issue 6, Page 587-602, June 2026.
This review describes how an integrated structural biology platform at Merck Sharp & Dohme LLC, Rahway, New Jersey, USA, combining X‐ray crystallography, cryo‐EM, MicroED and cryo‐ET, enables seamless three‐dimensional insights from molecular to cellular length scales.
Jill E. Chrencik   +44 more
wiley   +1 more source

Expert Consensus on Trendelenburg Position Postless Hip Distraction Technique in Hip Arthroscopy

open access: yesOrthopaedic Surgery, Volume 18, Issue 6, Page 1103-1115, June 2026.
This work evaluates the Trendelenburg position postless hip distraction technique for hip arthroscopy, highlighting its safety, efficacy, cost‐effectiveness, and key clinical application points. ABSTRACT Postless hip distraction technique is a novel traction method for hip arthroscopy developed in recent years.
Yaoting Wang   +11 more
wiley   +1 more source

Juvenile X-Linked retinoschisis: Response to topical dorzolamide therapy

open access: yesTNOA Journal of Ophthalmic Science and Research, 2018
We report clinical course of a 22-year-old Indian male patient presenting with bilateral Juvenile X-linked retinoschisis (JXLRS) in response to topical 2% dorzolamide hydrochloride treatment.
Krati Gupta   +5 more
doaj   +1 more source

Drug‐Induced Raynaud's Phenomenon and Underlying Mechanism: A Disproportionality Analysis From the World Health Organization Pharmacovigilance Database

open access: yesArthritis &Rheumatology, Volume 78, Issue 4, Page 985-992, April 2026.
Objectives The aim of this study is to generate hypotheses about unknown drugs associated with the onset or worsening of Raynaud's phenomenon (RP) and to explore their potential pathophysiologic mechanisms through a mixed disproportionality/clustering analysis from the World Health Organization (WHO) pharmacovigilance database.
Alex Hlavaty   +4 more
wiley   +1 more source

Sex‐specific elevated incidence of glaucoma associated with topiramate versus valproate or lamotrigine in epilepsy, not migraine: A population‐based cohort study

open access: yesEpilepsia, Volume 67, Issue 4, Page 1690-1702, April 2026.
Abstract Objective Topiramate has been linked to increased glaucoma risk, potentially through mechanisms involving ocular fluid shifts. However, comparative risks vs other antiseizure medications (ASMs) and variation by sex or indication remain uncertain.
Cuiling Wei   +10 more
wiley   +1 more source

24-hour intraocular pressure in glaucoma patients randomized to receive dorzolamide or brinzolamide in combination with latanoprost

open access: yesClinical Ophthalmology, 2009
Yoshimi Nakamura, Shusaku Ishikawa, Yuko Nakamura, Hiroshi Sakai, Ichiko Henzan, Shoichi SawaguchiDepartment of Ophthalmology, University of the Ryukyus Faculty of Medicine, Okinawa, JapanPurpose: To investigate the efficacy of dorzolamide 1% (bid or tid)
Yoshimi Nakamura   +4 more
doaj  

Effects of dorzolamide/timolol and tafluprost on intraocular pressure and pupil diameter in healthy dogs

open access: yesCiência Rural
: This study aimed to evaluate and compare the effects of the fixed combination of dorzolamide/timolol with those of tafluprost on intraocular pressure (IOP) and pupil diameter (PD) in healthy dogs (n=10).
Nathalie Moro Bassil Dower   +6 more
doaj   +1 more source

Treatment of cystic cavities in X-linked juvenile retinoschisis: The first sequential cross-over treatment regimen with dorzolamide

open access: yesAmerican Journal of Ophthalmology Case Reports, 2017
Purpose: To report the first sequential cross-over treatment with the longest ophthalmic follow-up in a case of X-linked juvenile retinoschisis (XLRS) successfully treated with topical dorzolamide.
Razek Georges Coussa   +1 more
doaj   +1 more source

Clinical‐Pharmacological Drug Information Center of Hannover Medical School: Update From a Tertiary Care University Hospital (2022–2024)

open access: yesPharmacology Research &Perspectives, Volume 14, Issue 2, April 2026.
ABSTRACT Drug information centers (DICs) are institutions dedicated to providing independent and up‐to‐date information on medications and their usage to healthcare professionals. Here, we provide an update from the clinical‐pharmacological DIC of Hannover Medical School, covering the period from April 2022 to December 2024.
Johannes Heck   +12 more
wiley   +1 more source

Ocular hypotensive effects of a Rho-associated protein kinase inhibitor in rabbits

open access: yesClinical Ophthalmology, 2017
Muhammad Irfan Kamaruddin,1,2 Momoko Nakamura-Shibasaki,1 Yu Mizuno,1 Yoshiaki Kiuchi1 1Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan; 2Department of Ophthalmology ...
Kamaruddin MI   +3 more
doaj  

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