Results 71 to 80 of about 39,387 (246)

X-Chromosome Dosage Modulates Multiple Molecular and Cellular Properties of Mouse Pluripotent Stem Cells Independently of Global DNA Methylation Levels

Stem Cell Reports, 2019
Summary: Reprogramming female mouse somatic cells into induced pluripotent stem cells (iPSCs) leads to X-chromosome reactivation. The extent to which increased X-chromosome dosage (X-dosage) in female iPSCs compared with male iPSCs leads to differences ...
Juan Song, Adrian Janiszewski, Natalie De Geest, Lotte Vanheer, Irene Talon, Mouna El Bakkali, Taeho Oh, Vincent Pasque   +7 more
doaj   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Targeting and regulatory mechanisms in chromosome-wide gene regulation using Drosophila melanogaster as a model organism [PDF]

, 2010
Tese de mestrado. Biologia (Biologia Molecular e Genética). Universidade de Lisboa, Faculdade de Ciências, 2010O cromossoma 4 de Drosophila melanogaster é muito heterocromático, sendo rico em DNA satélite e DNA de elementos transposáveis. Apesar das suas
Figueiredo, Ana Margarida Adónis, 1986-
core  

How to make a sex chromosome [PDF]

, 2016
Sex chromosomes can evolve once recombination is halted between a homologous pair of chromosomes. Owing to detailed studies using key model systems, we have a nuanced understanding and a rich review literature of what happens to sex chromosomes once ...
A Auton, A Auton, A Burt, A Kong, A McNair, AE Wright, AE Wright, AG Hinch, AK Chippindale, AST Papadopulos, B Charlesworth, B Charlesworth, B Charlesworth, B Charlesworth, B Lemos, B Payer, B Vicoso, B Vicoso, B Vicoso, BT Lahn, C Dufresnes, C Kupper, C Lemaitre, C Mullon, D Bachtrog, D Bachtrog, D Bachtrog, D Bachtrog, D Bachtrog, D Charlesworth, D Charlesworth, D Charlesworth, E Suomalai, ED Parvanov, F Baudat, GS van Doorn, GS van Doorn, H Muller, H Skaletsky, H Wallace, HK Moghadam, HM Natri, I Miura, IL Berg, J Haldane, J Hough, J Ironside, J Kitano, J Lange, J Wang, JA Tennessen, JE Mank, JE Mank, JE Mank, JE Mank, JF Flot, JL Feder, JP Wang, JR Ser, K Choi, K Matsubara, LB Koerich, LD Brooks, M Joron, M Nakamura, M Roesti, M Rovatsos, M Stock, M Stock, M White, MA Wilson, MG Poggio, MJ Wyman, MJD White, MT Ross, MV Chibalina, N Perrin, Q Zhou, Q Zhou, Q Zhou, R Bergero, R Bergero, R Bergero, R Bergero, R Gorelick, R Ming, RA Fisher, RB Roberts, RB Spigler, RS Pandey, S Ahmed, S Grozeva, S Lamichhaney, S Myers, S Myers, S Naurin, S Nokkala, S Singhal, S Yoshimoto, SS Renner, T Dobzhansky, T Dobzhansky, T Dobzhansky, T Gamble, T Kamiya, T Lenormand, T Lenormand, T Morgan, VB Bardella, WR Rice, WR Rice, YQS Soh, ZY Liu, Ö Winge   +113 more
core   +2 more sources

The genome-wide transcriptional consequences of the nullisomic-tetrasomic stocks for homoeologous group 7 in bread wheat

BMC Genomics, 2019
Background Hexaploid bread wheat (Triticum aestivum L) arose by two polyploidisation events from three diploid species with homoeologous genomes. Nullisomic-tetrasomic (nulli-tetra or NT) lines are aneuploid wheat plants lacking two and adding two of six
Rongzhi Zhang, Shuaifeng Geng, Zhengrui Qin, Zongxiang Tang, Cheng Liu, Dongfeng Liu, Guoqi Song, Yulian Li, Shujuan Zhang, Wei Li, Jie Gao, Xiaodong Han, Genying Li   +12 more
doaj   +1 more source

Chromosome X-wide association study identifies Loci for fasting insulin and height and evidence for incomplete dosage compensation. [PDF]

PLoS Genetics, 2014
The X chromosome (chrX) represents one potential source for the "missing heritability" for complex phenotypes, which thus far has remained underanalyzed in genome-wide association studies (GWAS). Here we demonstrate the benefits of including chrX in GWAS
Taru Tukiainen, Matti Pirinen, Antti-Pekka Sarin, Claes Ladenvall, Johannes Kettunen, Terho Lehtimäki, Marja-Liisa Lokki, Markus Perola, Juha Sinisalo, Efthymia Vlachopoulou, Johan G Eriksson, Leif Groop, Antti Jula, Marjo-Riitta Järvelin, Olli T Raitakari, Veikko Salomaa, Samuli Ripatti   +16 more
doaj   +1 more source

COVID‐19 Vaccination is not Associated with the Development of Idiopathic Inflammatory Myositis in U.S. Veterans

Arthritis Care &Research, Accepted Article.
Objective Several case reports have proposed a potential association between COVID‐19 vaccination and the subsequent development of idiopathic inflammatory myositis (IIM). This study examined prior COVID‐19 vaccination in US Veterans who developed new‐onset IIM compared to those without new‐onset IIM.
Caleb Hernández, Naomi Schlesinger, Jorge Rojas, Jessica A. Walsh, Tawnie J Braaten, Gary A Kunkel, Makoto Jones, Brian C Sauer, Julio Facelli, Grant W. Cannon, Dorota Lebiedz‐Odrobina   +10 more
wiley   +1 more source

Chromosomal control of wheat endosperm proteins. A critical review. [PDF]

, 1977
Progress made in the chromosomal location of structural genes for wheat endosperm proteins, and in the study of the regulation and quantitative expression of these genes, by using aneuploids and by related techniques, is critically evaluated ...
Aragoncillo Ballesteros, Cipriano, Carbonero Zalduegui, Pilar, García Olmedo, Francisco, Salcedo Duran, Gabriel   +3 more
core   +2 more sources

Incomplete sex chromosome dosage compensation in the Indian meal moth, Plodia interpunctella, based on de novo transcriptome assembly. [PDF]

, 2016
Journal ArticleResearch Support, Non-U.S. Gov'tMales and females experience differences in gene dose for loci in the nonrecombining region of heteromorphic sex chromosomes. If not compensated, this leads to expression imbalances, with the homogametic sex
Harrison, PW, Mank, JE, Wedell, Nina
core   +1 more source

A network of HSPG core proteins and HS modifying enzymes regulates netrin-dependent guidance of D-type motor neurons in Caenorhabditis elegans. [PDF]

PLoS ONE, 2013
Heparan sulfate proteoglycans (HSPGs) are proteins with long covalently attached sugar side chains of the heparan sulfate (HS) type. Depending on the cellular context HS chains carry multiple structural modifications such as sulfate residues or ...
Stephan Gysi, Christa Rhiner, Stephane Flibotte, Donald G Moerman, Michael O Hengartner   +4 more
doaj   +1 more source