Results 91 to 100 of about 2,454,279 (380)

The Importance of Body Weight for the Dose Response Relationship of Oral Vitamin D Supplementation and Serum 25-Hydroxyvitamin D in Healthy Volunteers

PLoS ONE, 2014
Unlike vitamin D recommendations by the Institute of Medicine, the Clinical Practice Guidelines by the Endocrine Society acknowledge body weight differentials and recommend obese subjects be given two to three times more vitamin D to satisfy their body's
J. P. Ekwaru, Jennifer D. Zwicker, M. Holick, E. Giovannucci, P. Veugelers   +4 more
semanticscholar   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Dose-response study of propofol combined with two different doses of esketamine for laryngeal mask airway insertion in women undergoing hysteroscopy

Heliyon
Objective: To prospectively determine the median effective dose (ED50) of propofol for inhibiting a response to laryngeal mask airway (LMA) insertion when combined with different doses of esketamine in female patients.
Yan-Jun Lin, Su-Li Chen, Xiang-Li Zheng, Shuang Yu, Liang-Yuan Lu   +4 more
doaj   +1 more source

Estimation of the vascular resistance amplifier in the renal vascular bed in conscious hypertensive rabbits: comparison with the total peripheral vasculature

Heliyon, 2020
Objectives: The vascular amplifier in hypertension is a result of structural changes in resistance arteries. We estimated the vascular amplifier hypertensive:normotensive (H:N) ratio in the renal bed compared with the total peripheral bed in conscious ...
Makhala M. Khammy, James A. Angus, Christine E. Wright   +2 more
doaj   +1 more source

An Empirical Transmitted EPID Dosimetry Method using a Back-Projection Algorithm [PDF]

Journal of Biomedical Physics and Engineering, 2019
Background: The present study aimed to introduce a rapid transmission dosimetry through an electronic portal-imaging device (EPID) to achieve two-dimensional (2D) dose distribution for homogenous environments. Material and Methods: In this Phantom study,
S M Hashemi, M H Bahreyni, M Mohammadi, S Nasseri, S Bayani, H Gholamhosseinian, R Salek, F Shahedi, M Momennezhad   +8 more
doaj   +1 more source

A Linear Dose-Response Relationship between Fasting Plasma Glucose and Colorectal Cancer Risk: Systematic Review and Meta-analysis

Scientific Reports, 2015
For many years, the question of whether hyperglycaemia, a manifestation of prediabetes, diabetes mellitus and metabolic syndrome, is a risk factor for colorectal cancer has been intensely studied. In fact, even after the conclusion of several prospective
Jianguo Shi, L. Xiong, Jiaoyuan Li, H. Cao, Wen Jiang, Bo Liu, Xueqin Chen, Cheng Liu, Ke Liu, Guobin Wang, K. Cai   +10 more
semanticscholar   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Chronic inducible urticaria: confirmation through challenge tests and response to treatment

Einstein (São Paulo), 2020
Objective To evaluate the positivity of challenge tests of patients suspected of chronic inducible urticaria and the response to treatment. Methods A retrospective study of electronic medical records of patients suspected of chronic inducible ...
Amanda Rocha Firmino Pereira, Antônio Abílio Motta, Jorge Kalil, Rosana Câmara Agondi   +3 more
doaj   +2 more sources

Practical considerations for optimal designs in clinical dose finding studies [PDF]

Determining an adequate dose level for a drug and, more broadly, characterizing its dose response relationship, are key objectives in the clinical development of any medicinal drug. If the dose is set too high, safety and tolerability problems are likely
Bretz, Frank, Dette, Holger, Pinheiro, José   +2 more
core  

Relationship of Sleep Duration With All‐Cause Mortality and Cardiovascular Events: A Systematic Review and Dose‐Response Meta‐Analysis of Prospective Cohort Studies

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2017
Background Effects of extreme sleep duration on risk of mortality and cardiovascular outcomes remain controversial. We aimed to quantify the dose‐response relationships of sleep duration with risk of all‐cause mortality, total cardiovascular disease ...
Jiawei Yin, Xiaoling Jin, Zhilei Shan, Shuzhen Li, Hao Huang, Peiyun Li, Xiaobo Peng, Zhao Peng, Kaifeng Yu, W. Bao, Wei Yang, Xiaoyi Chen, Liegang Liu   +12 more
semanticscholar   +1 more source