Results 91 to 100 of about 1,339,184 (328)

Effects of the Shape of the Radiation Dose-Response Curve on Public Acceptance of Radiation and Nuclear Energy [PDF]

, 2002
[Excerpt] “The public generally accepts the premise that exposure to radiation can have an undesirable effect. Furthermore, it believes that as the radiation dose increases, the magnitude of the effect will increase.
Fentiman, Audeen W.
core   +1 more source

An investigation of thresholds in air pollution-mortality effects [PDF]

, 2004
In this paper we introduce and implement new techniques to investigate threshold effects in air pollution-mortality relationships. Our key interest is in measuring the dose-response relationship above and below a given threshold level where we allow for ...
Clyde, Daniels, Delfino, Dockery, Dominici, Draper, Fairly, Fernandez, Fernandez, Gary Koop, Hodges, Hoeting, Hurley, Koop, Koop, Lim, Lise Tole, Madigan, Meng, Ordieres, Ostro, Pope, Raftery, Schwartz, Schwartz, Schwartz, Schwartz, Schwartz, Schwartz, Schwartz, Schwartz, Schwartz, Schwartz, Schwartz, Schwartz, Smith, Xu   +36 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Dose-response study of propofol combined with two different doses of esketamine for laryngeal mask airway insertion in women undergoing hysteroscopy

Heliyon
Objective: To prospectively determine the median effective dose (ED50) of propofol for inhibiting a response to laryngeal mask airway (LMA) insertion when combined with different doses of esketamine in female patients.
Yan-Jun Lin, Su-Li Chen, Xiang-Li Zheng, Shuang Yu, Liang-Yuan Lu   +4 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

CRP–triglyceride–glucose index (CTGI) as a predictor of preeclampsia: a population-based study of risk stratification

Lipids in Health and Disease
Background preeclampsia (PE) remains a leading cause of maternal and perinatal morbidity and mortality worldwide. While metabolic and inflammatory factors are increasingly recognized in its pathogenesis, the clinical utility of composite biomarkers ...
Yuting Liang, Yanqiu Zhang, Yujing Li, Jun Cao, Bin Feng, Jieyu Jin, Sheng Zhang, Qingqin Tang, Longwei Qiao, Zhixing Jin   +9 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Performance of an adapted household food insecurity access scale in measuring seasonality in household food insecurity in rural Ethiopia: a cohort analysis

BMC Nutrition, 2019
Background Seasonality poses a considerable food security challenge in Ethiopia. Yet, measuring seasonal variations in food insecurity, particularly the dimension of food access, lacks an adequately validated tool.
Bereket Yohannes Kabalo, Seifu Hagos Gebreyesus, Eskindir Loha, Bernt Lindtjørn   +3 more
doaj   +1 more source

Western corn rootworm pyrethroid resistance confirmed by aerial application simulations of commercial insecticides [PDF]

, 2019
The western corn rootworm (Diabrotica virgifera virgifera LeConte) (WCR) is a major insect pest of corn (Zea mays L.) in the United States (US) and is highly adaptable to multiple management tactics.
Fritz, Bradley K., Hoffmann, Wesley C., Kruger, Greg, Meinke, Lance J., Peterson, Julie A., Souza, Dariane, Vieira, Bruno C.   +6 more
core   +1 more source

Dose-response relationship between sports activity and musculoskeletal pain in adolescents. [PDF]

, 2016
Physical activity has multiple health benefits but may also increase the risk of developing musculoskeletal pain (MSP). However, the relationship between physical activity and MSP has not been well characterized.
Abe, Takafumi, Imamura, Fumiaki, Kadowaki, Masaru, Kamada, Masamitsu, Kitayuguchi, Jun, Lee, I-Min, Matsui, Yuzuru, Miyachi, Motohiko, Sawada, Susumu S, Uchio, Yuji   +9 more
core   +2 more sources