Results 101 to 110 of about 1,785,940 (367)
Cancer Medicine, 2018 Radotinib is a second‐generation BCR‐ABL1 tyrosine kinase inhibitor approved for the treatment of chronic myeloid leukemia in chronic phase (CP‐CML). Here, using the data from a Phase 3 study conducted in patients with newly diagnosed CP‐CML, the dose ...
Hayeon Noh +12 more
doaj +1 more source
Inferring Internet AS Relationships Based on BGP Routing Policies [PDF]
arXiv, 2011 The type of business relationships between the Internet autonomous systems (AS) determines the BGP inter-domain routing. Previous works on inferring AS relationships relied on the connectivity information between ASes. In this paper we infer AS relationships by analysing the routing polices of ASes encoded in the BGP attributes Communities and the ...
arxiv
Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance
Molecular Oncology, EarlyView.Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren +4 more
wiley +1 more source
Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value
Molecular Oncology, EarlyView.The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song +13 more
wiley +1 more source
Scientific Reports, 2014 Targeting cancer via ROS-based mechanism has been proposed as a radical therapeutic approach. Cancer cells exhibit higher endogenous oxidative stress than normal cells and pharmacological ROS insults via either enhancing ROS production or inhibiting ROS ...
Chunpeng Zhu, Wei Hu, Hao Wu, Xun Hu
semanticscholar +1 more source
Molecular Oncology, EarlyView.Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé +7 more
wiley +1 more source
BMC CancerObjective This study aimed to establish the dose-response relationship between volume base dose and tumor local control for vaginal cancer, including primary vaginal cancer and recurrent gynecologic malignancies in the vagina.
Zhiqiang Wang, Xin Guo, Hongfu Zhao
doaj +1 more source
International Journal of General Medicine, 2021 Wen Ma,1,2,* Zhengwei Yan,2,* Wentao Wu,2 Daning Li,2 Shuai Zheng,3 Jun Lyu1– 3 1Clinical Research Center, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 2School of Public ...
Ma W, Yan Z, Wu W, Li D, Zheng S, Lyu J
doaj
Confidence bounds for nonlinear dose–response relationships
Statistics in Medicine, 2015 An important aim of drug trials is to characterize the dose–response relationship of a new compound. Such a relationship can often be described by a parametric (nonlinear) function that is monotone in dose. If such a model is fitted, it is useful to know the uncertainty of the fitted curve.
Corine Baayen +2 more
openaire +4 more sources
Annals of Oncology, 2013 This study aimed to conduct a systematic review to sum up evidence of the associations between different aspects of night shift work and female breast cancer using a dose-response meta-analysis approach.
Feng Wang +9 more
semanticscholar +1 more source