Results 111 to 120 of about 1,785,940 (367)

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Optimal dose and type of exercise to improve depressive symptoms in older adults: a systematic review and network meta-analysis

BMC Geriatrics
Background Depression is a prevalent issue among older adults, affecting their quality of life and overall well-being. Exercise is an effective means of relieving depressive symptoms in older adults, but the optimal dose for different exercise types ...
Lili Tang, Lin Zhang, Yanbo Liu, Yan Li, Lijuan Yang, Mingxuan Zou, Huiran Yang, Lingyu Zhu, Ruihong Du, Ye Shen, Haoyu Li, Yong Yang, Zhijun Li   +12 more
doaj   +1 more source

Mining Essential Relationships under Multiplex Networks [PDF]

arXiv, 2015
In big data times, massive datasets often carry different relationships among the same group of nodes, analyzing on these heterogeneous relationships may give us a window to peek the essential relationships among nodes. In this paper, first of all we propose a new metric "similarity rate" in order to capture the changing rate of similarities between ...
arxiv  

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Modelling the therapeutic dose range of single low dose primaquine to reduce malaria transmission through age-based dosing

BMC Infectious Diseases, 2017
Background Low-dose primaquine is a key candidate for use in malaria transmission reduction and elimination campaigns such as mass drug administration (MDA).
Daniel Joseph Hayes, Clifford George Banda, Alexandra Chipasula-Teleka, Dianne Janette Terlouw   +3 more
doaj   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Evaluation of the Comet Assay for Assessing the Dose-Response Relationship of DNA Damage Induced by Ionizing Radiation

International Journal of Molecular Sciences, 2013
Dose- and time-response curves were combined to assess the potential of the comet assay in radiation biodosimetry. The neutral comet assay was used to detect DNA double-strand breaks in lymphocytes caused by γ-ray irradiation.
Yan Wang, Chang Xu, Liqing Du, Jia Cao, Jian Xiang Liu, Xuebin Su, Hui Zhao, F. Fan, B. Wang, T. Katsube, Saijun Fan, Qiang Liu   +11 more
semanticscholar   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Entity-Relationship Search over the Web [PDF]

arXiv, 2018
Entity-Relationship (E-R) Search is a complex case of Entity Search where the goal is to search for multiple unknown entities and relationships connecting them. We assume that a E-R query can be decomposed as a sequence of sub-queries each containing keywords related to a specific entity or relationship.
arxiv  

THE DOSE RESPONSE RELATIONSHIP AND DURATION OF ACTION OF SUCCINYLCHOLINE IN ANESTHETIZED MAN [PDF]

, 1954
Armando Meraz Espinosa, Joseph F. Artusio   +1 more
openalex   +1 more source