Results 141 to 150 of about 395,390 (239)

An improved method for the detection of double-stranded RNA suitable for quality control of mRNA vaccines. [PDF]

open access: yesProtein Cell
Liu J   +9 more
europepmc   +1 more source

Histone Lactylation Antagonizes Senescence and Skeletal Muscle Aging by Modulating Aging‐Related Pathways

open access: yesAdvanced Science, EarlyView.
This study reveals histone lactylation as a metabolic‐epigenetic regulator countering cellular senescence and skeletal muscle aging. Reduced lactylation impairs cell cycle, DNA repair and proteostasis pathways, while exercise restores glycolytic activity and lactylation levels, preserving muscle function.
Fanju Meng   +16 more
wiley   +1 more source

Mitochondrial double-stranded RNA homeostasis depends on cell-cycle progression. [PDF]

open access: yesLife Sci Alliance
Xavier V   +13 more
europepmc   +1 more source

PROS1‐MERTK Axis Drives Tumor Microenvironment Crosstalk and Progression in Papillary Thyroid Microcarcinoma

open access: yesAdvanced Science, EarlyView.
Identifying biomarkers associated with PTC, particularly those related to PTMC progression, is crucial for precise risk stratification and treatment planning. This study utilized single‐cell RNA sequencing on 19 surgical tissue specimens, confirmed PROS1/MERTK axis as a critical component of the cellular microenvironment and a key regulatory mechanism ...
Wenqian Zhang   +11 more
wiley   +1 more source

Structural basis for double-stranded RNA recognition by SID1. [PDF]

open access: yesNucleic Acids Res
Wang R, Cong Y, Qian D, Yan C, Gong D.
europepmc   +1 more source

Purification of linearized template plasmid DNA decreases double-stranded RNA formation during IVT reaction. [PDF]

open access: yesFront Mol Biosci, 2023
Martínez J   +4 more
europepmc   +1 more source

KLF1 Promotes Cardiomyocyte Proliferation and Heart Regeneration Through Regulation of Wnt/β‐Catenin Signaling Pathway

open access: yesAdvanced Science, EarlyView.
In KLF1‐on (neonatal and Klf1 overexpression hearts) models, KLF1 regulates Wnt/β‐catenin signaling pathway and the expression of cell proliferation‐related genes via transcriptional and epigenetic mechanisms, which induces cardiomyocyte proliferation and cardiac regeneration in mice after myocardial infarction.
Yanglin Hao   +19 more
wiley   +1 more source

Trafficking of mitochondrial double-stranded RNA from mitochondria to the cytosol. [PDF]

open access: yesLife Sci Alliance
Krieger MR   +13 more
europepmc   +1 more source

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