Results 241 to 250 of about 419,931 (303)

Junctophilin-2 is a double-stranded RNA-binding protein that regulates cardiomyocyte-autonomous innate immune response. [PDF]

Biochem Biophys Res Commun
Shi Y, Mirabdali S, Vetter SW, Guo A.
europepmc   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Double-stranded RNA orbivirus disrupts the DNA-sensing cGAS-sting axis to prevent type I IFN induction. [PDF]

Cell Mol Life Sci
Louloudes-Lázaro A, Nogales-Altozano P, Rojas JM, Veloz J, Carlón AB, Van Rijn PA, Martín V, Fernández-Sesma A, Sevilla N.   +8 more
europepmc   +1 more source

Design of Safe and Efficient Adenine Base Editors via Protein Language Model Screening for Osteoarthritis Treatment

Advanced Science, EarlyView.
ABSTRACT Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single‐nucleotide variants. While the current efficient version of adenine base editors (ABEs), such as ABE8e, exhibits exceptional efficiency for A‐to‐G conversions, their clinical translation is hindered by ...
Jiawei Yao, Dalin Chen, Ziyi Zhang, Jingxuan Ren, Chengcheng Zhao, Shengfang Wang, Mengyu Shang, Dawei Jiang, Yinuo Li, Su'an Tang, Kai Li, Xiaohui Zhang, Xiaogang Wang   +12 more
wiley   +1 more source

Double stranded RNA sensing drives interferon silencing in early development

Witteveldt J, Liu Z, Ariza-Cosano A, Ramirez C, Walters JL, Marchante PG, Maas L, Ivens A, Tebaldi T, Heras SR, Marks H, Macias S.   +11 more
europepmc   +1 more source

Vitamin D3/VDR alleviates double-stranded RNA virus -induced biliary epithelial cell damage by inhibiting autophagy. [PDF]

BMC Gastroenterol
Liu N, Zhao P, Cao P, Hui J, Pan Y, Cheng J.   +5 more
europepmc   +1 more source

Reverse-phase chromatography removes double-stranded RNA, fragments, and residual template to decrease immunogenicity and increase cell potency of mRNA and saRNA. [PDF]

Mol Ther Nucleic Acids
Krušič A, Mencin N, Leban M, Nett E, Perković M, Sahin U, Megušar P, Štrancar A, Sekirnik R.   +8 more
europepmc   +1 more source

Correction: Budesonide promotes airway epithelial barrier integrity following double-stranded RNA challenge. [PDF]

PLoS One
Rimmer C, Hetelekides S, Eliseeva SI, Georas SN, Veazey JM.   +4 more
europepmc   +1 more source

Induction of apoptosis by double-stranded RNA was present in the last common ancestor of cnidarian and bilaterian animals. [PDF]

PLoS Pathog
Kozlovski I, Jaimes-Becerra A, Sharoni T, Lewandowska M, Karmi O, Moran Y.   +5 more
europepmc   +1 more source